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The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[2]
Janssens R, Communi D, Pirotton S, Samson M, Parmentier M, Boeynaems JM (April 1996). "Cloning and tissue distribution of the human P2Y1 receptor". Biochemical and Biophysical Research Communications. 221 (3): 588–93. doi:10.1006/bbrc.1996.0640. PMID8630005.
Léon C, Vial C, Cazenave JP, Gachet C (June 1996). "Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor". Gene. 171 (2): 295–7. doi:10.1016/0378-1119(96)00027-3. PMID8666290.
Léon C, Hechler B, Vial C, Leray C, Cazenave JP, Gachet C (February 1997). "The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells". FEBS Letters. 403 (1): 26–30. doi:10.1016/S0014-5793(97)00022-7. PMID9038354.
Ayyanathan K, Naylor SL, Kunapuli SP (September 1996). "Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1)". Somatic Cell and Molecular Genetics. 22 (5): 419–24. doi:10.1007/BF02369897. PMID9039850.
Maier R, Glatz A, Mosbacher J, Bilbe G (August 1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochemical and Biophysical Research Communications. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID9268704.
Jin J, Daniel JL, Kunapuli SP (January 1998). "Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets". The Journal of Biological Chemistry. 273 (4): 2030–4. doi:10.1074/jbc.273.4.2030. PMID9442040.
James G, Butt AM (October 2001). "Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve". Neuroscience Letters. 312 (1): 33–6. doi:10.1016/S0304-3940(01)02189-9. PMID11578839.
Moore DJ, Chambers JK, Wahlin JP, Tan KB, Moore GB, Jenkins O, Emson PC, Murdock PR (October 2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochimica et Biophysica Acta. 1521 (1–3): 107–19. doi:10.1016/S0167-4781(01)00291-3. PMID11690642.
Czajkowski R, Lei L, Sabała P, Barańska J (February 2002). "ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12)". FEBS Letters. 513 (2–3): 179–83. doi:10.1016/S0014-5793(02)02255-X. PMID11904146.
Aktas B, Hönig-Liedl P, Walter U, Geiger J (August 2002). "Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase". Biochemical Pharmacology. 64 (3): 433–9. doi:10.1016/S0006-2952(02)01113-9. PMID12147294.
Nurden P, Poujol C, Winckler J, Combrié R, Pousseau N, Conley PB, Levy-Toledano S, Habib A, Nurden AT (February 2003). "Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system". Blood. 101 (4): 1400–8. doi:10.1182/blood-2002-02-0642. PMID12393588.
Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (March 2003). "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors". The Journal of Investigative Dermatology. 120 (3): 440–7. doi:10.1046/j.1523-1747.2003.12050.x. PMID12603858.
Jagroop IA, Burnstock G, Mikhailidis DP (February 2003). "Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets". Platelets. 14 (1): 15–20. doi:10.1080/0953710021000062914. PMID12623443.
Greig AV, Linge C, Terenghi G, McGrouther DA, Burnstock G (June 2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes". The Journal of Investigative Dermatology. 120 (6): 1007–15. doi:10.1046/j.1523-1747.2003.12261.x. PMID12787128.
Wang L, Ostberg O, Wihlborg AK, Brogren H, Jern S, Erlinge D (February 2003). "Quantification of ADP and ATP receptor expression in human platelets". Journal of Thrombosis and Haemostasis. 1 (2): 330–6. doi:10.1046/j.1538-7836.2003.00070.x. PMID12871508.
External links
"P2Y Receptors: P2Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.