Osteosarcoma differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].

Overview

Osteosarcoma must be differentiated from other diseases such as: any type of bone lesions caused by infection and/or tumors. Features such as the eccentric location of the tumor in the metaphyseal portion of the bone and the skeletal location help to distinguish osteosarcoma from Ewing sarcoma. Bone metastases from other primary tumours, less frequent in the young than in adult patients, should also be considered.

Differentiating Osteosarcoma from other Diseases

Osteosarcoma must be differentiated from:Osteomyelitis, Pediatric Osteomyelitis, Rhabdomyosarcoma, Pediatric Rhabdomyosarcoma, Chondrosarcoma, Metastases from other malignancies, Fibrous dysplasia, Giant cell tumors, Ewing's sarcoma, Malignant fibrous histiocytoma, LymphomaOsteoblastoma, Aneurysmal bone cyst, Fibrosarcoma and Cortical desmoid.

Disease Bone involvement Bone pain Fever Fractures Mechanism ALK level Diagnosis
Osteoblastoma Single Yes No Yes Neoplasm High Radiology and biopsy
Osteosarcoma Single Yes No Yes Neoplasm Normal Radiology and biopsy
Osteoid osteoma Single Yes No Yes Neoplasm High Radiology and biopsy
Aneurysmal bone cyst Single Yes No No Neoplasm High Radiology and biopsy
Stress fracture Multiple Yes No Yes Stress Normal Radiology
Osteomyelitis Single Yes Yes No Infection Normal Radiology and biopsy
Brodie's abscess Single Yes Yes No Infection Normal Radiology and biopsy

References

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