Osteosarcoma differential diagnosis: Difference between revisions
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{{CMG}}; {{AE}}[[User:DrMars|Mohammadmain Rezazadehsaatlou[2]]]. | {{CMG}}; {{AE}}[[User:DrMars|Mohammadmain Rezazadehsaatlou[2]]]. | ||
==Overview== | ==Overview== | ||
Osteosarcoma must be differentiated from other diseases such as: any type of bone lesions caused by infection and/or tumors. | [[Osteosarcoma]] must be differentiated from other diseases such as: any type of bone [[Lesion|lesions]] caused by [[infection]] and/or [[Tumor|tumors]]. Features such as the [[Eccentric Lesion|eccentric]] location of the [[tumor]] in the [[metaphyseal]] portion of the bone and the [[skeletal]] location help to distinguish [[osteosarcoma]] from [[Ewing sarcoma]]. Bone [[metastases]] from other primary [[Tumour|tumours]], less frequent in the young than in adult patients, should also be considered. | ||
Features such as the eccentric location of the tumor in the metaphyseal portion of the bone and the skeletal location help to distinguish osteosarcoma from Ewing sarcoma. Bone metastases from other primary tumours, less frequent in the young than in adult patients, should also be considered. | |||
== Differentiating Osteosarcoma from other Diseases == | == Differentiating Osteosarcoma from other Diseases == | ||
Osteosarcoma must be differentiated from:[[Osteomyelitis]], [[Pediatric Osteomyelitis]], [[Rhabdomyosarcoma]], Pediatric Rhabdomyosarcoma[[Chondrosarcoma|, Chondrosarcoma]], Metastases from other malignancies, [[Fibrous dysplasia|Fibrous dysplasia,]] [[Giant cell tumor of bone|Giant cell tumors]][[Ewing's sarcoma|, Ewing's sarcoma]][[Malignant fibrous histiocytoma|, Malignant fibrous histiocytoma]][[Lymphoma|, Lymphoma]][[Osteoblastoma]][[Aneurysmal bone cyst|, Aneurysmal bone cyst]][[Fibrosarcoma|, Fibrosarcoma]] and Cortical desmoid. | [[Osteosarcoma]] must be differentiated from:[[Osteomyelitis]], [[Pediatric Osteomyelitis]], [[Rhabdomyosarcoma]], Pediatric Rhabdomyosarcoma[[Chondrosarcoma|, Chondrosarcoma]], Metastases from other malignancies, [[Fibrous dysplasia|Fibrous dysplasia,]] [[Giant cell tumor of bone|Giant cell tumors]][[Ewing's sarcoma|, Ewing's sarcoma]][[Malignant fibrous histiocytoma|, Malignant fibrous histiocytoma]][[Lymphoma|, Lymphoma]][[Osteoblastoma]][[Aneurysmal bone cyst|, Aneurysmal bone cyst]][[Fibrosarcoma|, Fibrosarcoma]] and Cortical desmoid. | ||
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Revision as of 13:55, 16 October 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].
Overview
Osteosarcoma must be differentiated from other diseases such as: any type of bone lesions caused by infection and/or tumors. Features such as the eccentric location of the tumor in the metaphyseal portion of the bone and the skeletal location help to distinguish osteosarcoma from Ewing sarcoma. Bone metastases from other primary tumours, less frequent in the young than in adult patients, should also be considered.
Differentiating Osteosarcoma from other Diseases
Osteosarcoma must be differentiated from:Osteomyelitis, Pediatric Osteomyelitis, Rhabdomyosarcoma, Pediatric Rhabdomyosarcoma, Chondrosarcoma, Metastases from other malignancies, Fibrous dysplasia, Giant cell tumors, Ewing's sarcoma, Malignant fibrous histiocytoma, LymphomaOsteoblastoma, Aneurysmal bone cyst, Fibrosarcoma and Cortical desmoid.
| Disease | Bone involvement | Bone pain | Fever | Fractures | Mechanism | ALK level | Diagnosis |
|---|---|---|---|---|---|---|---|
| Osteoblastoma | Single | Yes | No | Yes | Neoplasm | High | Radiology and biopsy |
| Osteosarcoma | Single | Yes | No | Yes | Neoplasm | Normal | Radiology and biopsy |
| Osteoid osteoma | Single | Yes | No | Yes | Neoplasm | High | Radiology and biopsy |
| Aneurysmal bone cyst | Single | Yes | No | No | Neoplasm | High | Radiology and biopsy |
| Stress fracture | Multiple | Yes | No | Yes | Stress | Normal | Radiology |
| Osteomyelitis | Single | Yes | Yes | No | Infection | Normal | Radiology and biopsy |
| Brodie's abscess | Single | Yes | Yes | No | Infection | Normal | Radiology and biopsy |