Osteosarcoma differential diagnosis: Difference between revisions

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== Differentiating Osteosarcoma from other Diseases ==
== Differentiating Osteosarcoma from other Diseases ==
Osteosarcoma must be differentiated from:<ref name="pmid19915470">{{cite journal |vauthors=Kim HJ, Chalmers PN, Morris CD |title=Pediatric osteogenic sarcoma |journal=Curr. Opin. Pediatr. |volume=22 |issue=1 |pages=61–6 |date=February 2010 |pmid=19915470 |doi=10.1097/MOP.0b013e328334581f |url=}}</ref><ref name="pmid25070231">{{cite journal |vauthors=Moore DD, Luu HH |title=Osteosarcoma |journal=Cancer Treat. Res. |volume=162 |issue= |pages=65–92 |date=2014 |pmid=25070231 |doi=10.1007/978-3-319-07323-1_4 |url=}}</ref><ref name="pmid20179183">{{cite journal |vauthors=Ilaslan H, Schils J, Nageotte W, Lietman SA, Sundaram M |title=Clinical presentation and imaging of bone and soft-tissue sarcomas |journal=Cleve Clin J Med |volume=77 Suppl 1 |issue= |pages=S2–7 |date=March 2010 |pmid=20179183 |doi=10.3949/ccjm.77.s1.01 |url=}}</ref><ref name="pmid21037356">{{cite journal |vauthors=Wu PK, Chen WM, Lee OK, Chen CF, Huang CK, Chen TH |title=The prognosis for patients with osteosarcoma who have received prior manipulative therapy |journal=J Bone Joint Surg Br |volume=92 |issue=11 |pages=1580–5 |date=November 2010 |pmid=21037356 |doi=10.1302/0301-620X.92B11.24706 |url=}}</ref><ref name="pmid29980176">{{cite journal |vauthors=Obiedat H, Alrabadi N, Sultan E, Al Shatti M, Zihlif M |title=The effect of ERCC1 and ERCC2 gene polymorphysims on response to cisplatin based therapy in osteosarcoma patients |journal=BMC Med. Genet. |volume=19 |issue=1 |pages=112 |date=July 2018 |pmid=29980176 |pmc=6035436 |doi=10.1186/s12881-018-0627-4 |url=}}</ref>
Osteosarcoma must be differentiated from:[[Osteomyelitis]], [[Pediatric Osteomyelitis]], [[Rhabdomyosarcoma]], Pediatric Rhabdomyosarcoma[[Chondrosarcoma|, Chondrosarcoma]], Metastases from other malignancies, [[Fibrous dysplasia|Fibrous dysplasia,]] [[Giant cell tumor of bone|Giant cell tumors]][[Ewing's sarcoma|, Ewing's sarcoma]][[Malignant fibrous histiocytoma|, Malignant fibrous histiocytoma]][[Lymphoma|, Lymphoma]][[Osteoblastoma]][[Aneurysmal bone cyst|, Aneurysmal bone cyst]][[Fibrosarcoma|, Fibrosarcoma]] and Cortical desmoid.
 
*[[Osteomyelitis]]
*[[Pediatric Osteomyelitis]]
*[[Rhabdomyosarcoma]]
*[[Pediatric Rhabdomyosarcoma]]
*[[Chondrosarcoma]]
*[[Metastases from other malignancies]]
*[[Fibrous dysplasia]]
*[[Giant cell tumor of bone|Giant cell tumors]]
*[[Ewing's sarcoma]]
*[[Malignant fibrous histiocytoma]]  
*[[Lymphoma]]
*[[Osteoblastoma]]  
*[[Aneurysmal bone cyst]]
*[[Fibrosarcoma]]
*Cortical desmoid
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{|
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Disease
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Disease

Revision as of 13:52, 16 October 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].

Overview

Osteosarcoma must be differentiated from other diseases such as: any type of bone lesions caused by infection and/or tumors.

Features such as the eccentric location of the tumor in the metaphyseal portion of the bone and the skeletal location help to distinguish osteosarcoma from Ewing sarcoma. Bone metastases from other primary tumours, less frequent in the young than in adult patients, should also be considered.

Differentiating Osteosarcoma from other Diseases

Osteosarcoma must be differentiated from:Osteomyelitis, Pediatric Osteomyelitis, Rhabdomyosarcoma, Pediatric Rhabdomyosarcoma, Chondrosarcoma, Metastases from other malignancies, Fibrous dysplasia, Giant cell tumors, Ewing's sarcoma, Malignant fibrous histiocytoma, LymphomaOsteoblastoma, Aneurysmal bone cyst, Fibrosarcoma and Cortical desmoid.

Disease Bone involvement Bone pain Fever Fractures Mechanism ALK level Diagnosis
Osteoblastoma Single Yes No Yes Neoplasm High Radiology and biopsy
Osteosarcoma Single Yes No Yes Neoplasm Normal Radiology and biopsy
Osteoid osteoma Single Yes No Yes Neoplasm High Radiology and biopsy
Aneurysmal bone cyst Single Yes No No Neoplasm High Radiology and biopsy
Stress fracture Multiple Yes No Yes Stress Normal Radiology
Osteomyelitis Single Yes Yes No Infection Normal Radiology and biopsy
Brodie's abscess Single Yes Yes No Infection Normal Radiology and biopsy

References

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