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{{SI}}
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{{CMG}} {{AE}} {{KS}} {{LRO}}


==Overview==
'''Osteolysis''' is the softening, absorption and destruction of bony tissue.


==Causes==
===Common Causes===
*[[Acroosteolysis]]
*[[Adamantinoma]]
*[[Aging]]
*[[Bone tumors]]
*[[Chondroblastoma]]
*[[Chondromyxoid fibroma]]
*[[Chronic inflammation]]
*[[Cleidocranial dysplasia]]
*[[Craniomandibular dermatodysostosis]]
*[[Desmoplastic fibroma]]
*[[Enchondroma]]
*[[Enchondromatosis]]
*[[Epithelioid hemangioendothelioma]]
*[[Ewing sarcoma]]
*[[Gorham vanishing bone disease]]
*[[Hairy cell leukaemia]]
*[[Hajdu-cheney syndrome]]
*[[Idiopathic multicentric osteolysis]]
*[[Myeloma]]
*[[Neuroblastoma]]
*[[Osteosarcoma]]
*[[Polyostotic fibrous dysplasia]]
*[[Polyostotic osteolytic expansile dysplasia]]
*[[Pyknodysostosis]]
*[[Reiter syndrome]]
*[[Subchondral stress fracture]]
*[[Torg-winchester syndrome]]
*[[Van bogaert-hozay syndrome]]


==Overview==
===Causes by Organ System===
'''Osteolysis''' is the softening, absorption and destruction of bony tissue.
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
|bgcolor="Beige"| [[Polyvinyl chloride]]
|-
|-bgcolor="LightSteelBlue"
| '''Dental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| [[Haim-munk syndrome]],  [[Mycetoma]],  [[Psoriasis]]
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| [[Peridontal disease]]
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| [[Hyperparathyroidism]]
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| [[Bonnet-dechaume-blanc syndrome]],  [[Gaucher disease]],  [[Haim-munk syndrome]],  [[Hajdu-cheney syndrome]],  [[Hutchinson-gilford progeria syndrome]],  [[Idiopathic multicentric osteolysis]],  [[Interleukin 1 receptor antagonist deficiency]],  [[Majeed syndrome]],  [[Systemic hyalinosis]],  [[Torg-winchester syndrome]],  [[Van bogaert-hozay syndrome]]
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| [[Gorham vanishing bone disease]],  [[Hairy cell leukaemia]],  [[Histiocytosis x]],  [[Sickle cell disease]]
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| [[Prosthetics]]
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| [[Cysts]],  [[Mycetoma]],  [[Peridontal disease]],  [[Secondary syphilis]],  [[Tertiary syphilis]]
|-
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| [[Acroosteolysis]],  [[Adamantinoma]],  [[Aging]],  [[Bone tumors]],  [[Chondroblastoma]],  [[Chondromyxoid fibroma]],  [[Chronic inflammation]],  [[Cleidocranial dysplasia]],  [[Craniomandibular dermatodysostosis]],  [[Desmoplastic fibroma]],  [[Enchondroma]],  [[Enchondromatosis]],  [[Epithelioid hemangioendothelioma]],  [[Ewing sarcoma]],  [[Gorham vanishing bone disease]],  [[Hajdu-cheney syndrome]],  [[Idiopathic multicentric osteolysis]],  [[Myeloma]],  [[Osteosarcoma]],  [[Polyostotic fibrous dysplasia]],  [[Polyostotic osteolytic expansile dysplasia]],  [[Pyknodysostosis]],  [[Reiter syndrome]],  [[Subchondral stress fracture]],  [[Torg-winchester syndrome]],  [[Van bogaert-hozay syndrome]]
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"| [[Bonnet-dechaume-blanc syndrome]],  [[Cleidocranial dysplasia]],  [[Craniomandibular dermatodysostosis]], [[Hereditary sensory and autonomic neuropathy type 2]],  [[Neuroblastoma]]
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| [[Adamantinoma]],  [[Bone tumors]],  [[Chondroblastoma]],  [[Chondromyxoid fibroma]],  [[Desmoplastic fibroma]],  [[Enchondroma]],  [[Enchondromatosis]],  [[Epithelioid hemangioendothelioma]],  [[Ewing sarcoma]],  [[Hairy cell leukaemia]],  [[Myeloma]],  [[Neuroblastoma]],  [[Osteosarcoma]]
|-
|-bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| [[Sarcoidosis]]
|-
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| [[Arithritis]],  [[Polyostotic fibrous dysplasia]],  [[Polyostotic osteolytic expansile dysplasia]],  [[Psoriasis]],  [[Reiter syndrome]],  [[Sarcoidosis]],  [[Systemic hyalinosis]],  [[Systemic sclerosis]]
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| [[Secondary syphilis]],  [[Tertiary syphilis]]
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| [[Frostbite]],  [[Subchondral stress fracture]]
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| [[Aging]], [[Chronic inflammation]]
|-
|}


== Differential Diagnosis ==  
===Cause in Alphabetical Order===
{{columns-list|3|
*[[Acroosteolysis]]
*[[Adamantinoma]]
*[[Aging]]
*[[Arithritis]]
*[[Bone tumors]]
*[[Bonnet-dechaume-blanc syndrome]]
*[[Chondroblastoma]]
*[[Chondromyxoid fibroma]]
*[[Chronic inflammation]]
*[[Cleidocranial dysplasia]]
*[[Craniomandibular dermatodysostosis]]
*[[Cysts]]
*[[Desmoplastic fibroma]]
*[[Enchondroma]]
*[[Enchondromatosis]]
*[[Epithelioid hemangioendothelioma]]
*[[Ewing sarcoma]]
*[[Frostbite]]
*[[Gaucher disease]]
*[[Gorham vanishing bone disease]]
*[[Haim-munk syndrome]]
*[[Hairy cell leukaemia]]
*[[Hajdu-cheney syndrome]]
*[[Hereditary sensory and autonomic neuropathy type 2]]
*[[Histiocytosis x]]
*[[Hutchinson-gilford progeria syndrome]]
*[[Hyperparathyroidism, primary]]
*[[Idiopathic multicentric osteolysis]]
*[[Interleukin 1 receptor antagonist deficiency]]
*[[Majeed syndrome]]
*[[Mycetoma]]
*[[Myeloma]]
*[[Neuroblastoma]]
*[[Osteosarcoma]]
*[[Peridontal disease]]
*[[Polyostotic fibrous dysplasia]]
*[[Polyostotic osteolytic expansile dysplasia]]
*[[Polyvinyl chloride]]
*[[Prosthetics]]
*[[Psoriasis]]
*[[Pyknodysostosis]]
*[[Reiter syndrome]]
*[[Sarcoidosis]]
*[[Secondary syphilis]]
*[[Sickle cell disease]]
*[[Subchondral stress fracture]]
*[[Systemic hyalinosis]]
*[[Systemic sclerosis]]
*[[Tertiary syphilis]]
*[[Torg-winchester syndrome]]
*[[Van bogaert-hozay syndrome]]
}}
==Differential Diagnosis==  


In alphabetical order. <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>
In alphabetical order. <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>

Revision as of 16:49, 10 January 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2] Luke Rusowicz-Orazem, B.S.

Overview

Osteolysis is the softening, absorption and destruction of bony tissue.

Causes

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning Polyvinyl chloride
Dental No underlying causes
Dermatologic Haim-munk syndrome, Mycetoma, Psoriasis
Drug Side Effect No underlying causes
Ear Nose Throat Peridontal disease
Endocrine Hyperparathyroidism
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic Bonnet-dechaume-blanc syndrome, Gaucher disease, Haim-munk syndrome, Hajdu-cheney syndrome, Hutchinson-gilford progeria syndrome, Idiopathic multicentric osteolysis, Interleukin 1 receptor antagonist deficiency, Majeed syndrome, Systemic hyalinosis, Torg-winchester syndrome, Van bogaert-hozay syndrome
Hematologic Gorham vanishing bone disease, Hairy cell leukaemia, Histiocytosis x, Sickle cell disease
Iatrogenic Prosthetics
Infectious Disease Cysts, Mycetoma, Peridontal disease, Secondary syphilis, Tertiary syphilis
Musculoskeletal/Orthopedic Acroosteolysis, Adamantinoma, Aging, Bone tumors, Chondroblastoma, Chondromyxoid fibroma, Chronic inflammation, Cleidocranial dysplasia, Craniomandibular dermatodysostosis, Desmoplastic fibroma, Enchondroma, Enchondromatosis, Epithelioid hemangioendothelioma, Ewing sarcoma, Gorham vanishing bone disease, Hajdu-cheney syndrome, Idiopathic multicentric osteolysis, Myeloma, Osteosarcoma, Polyostotic fibrous dysplasia, Polyostotic osteolytic expansile dysplasia, Pyknodysostosis, Reiter syndrome, Subchondral stress fracture, Torg-winchester syndrome, Van bogaert-hozay syndrome
Neurologic Bonnet-dechaume-blanc syndrome, Cleidocranial dysplasia, Craniomandibular dermatodysostosis, Hereditary sensory and autonomic neuropathy type 2, Neuroblastoma
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Adamantinoma, Bone tumors, Chondroblastoma, Chondromyxoid fibroma, Desmoplastic fibroma, Enchondroma, Enchondromatosis, Epithelioid hemangioendothelioma, Ewing sarcoma, Hairy cell leukaemia, Myeloma, Neuroblastoma, Osteosarcoma
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary Sarcoidosis
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy Arithritis, Polyostotic fibrous dysplasia, Polyostotic osteolytic expansile dysplasia, Psoriasis, Reiter syndrome, Sarcoidosis, Systemic hyalinosis, Systemic sclerosis
Sexual Secondary syphilis, Tertiary syphilis
Trauma Frostbite, Subchondral stress fracture
Urologic No underlying causes
Miscellaneous Aging, Chronic inflammation

Cause in Alphabetical Order

The unnamed parameter 2= is no longer supported. Please see the documentation for {{columns-list}}.
3

Differential Diagnosis

In alphabetical order. [1] [2]

References

  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

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