OR2M4: Difference between revisions

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'''Olfactory receptor 2M4''' is a [[protein]] that in humans is encoded by the ''OR2M4'' [[gene]].<ref name="pmid1370859">{{cite journal | vauthors = Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J| title = Expression of members of the putative olfactory receptor gene family in mammalian germ cells | journal = Nature | volume = 355 | issue = 6359 | pages = 453–5 |date=Mar 1992 | pmid = 1370859 | pmc =  | doi = 10.1038/355453a0 |display-authors=etal}}</ref><ref name="pmid9119360">{{cite journal | vauthors = Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M | title = Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species | journal = Genomics | volume = 39 | issue = 3 | pages = 239–46 |date=Apr 1997 | pmid = 9119360 | pmc =  | doi = 10.1006/geno.1996.4490 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OR2M4 olfactory receptor, family 2, subfamily M, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26245| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 2, subfamily M, member 4
| HGNCid = 8270
| Symbol = OR2M4
| AltSymbols =; HSHTPCRX18; HTPCRX18; OR1-55; OST710; TPCR100
| OMIM =
| ECnumber =
| Homologene = 88846
| MGIid =
  | GeneAtlas_image1 = PBB_GE_OR2M4_gnf1h05779_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26245
    | Hs_Ensembl = ENSG00000171180
    | Hs_RefseqProtein = NP_059974
    | Hs_RefseqmRNA = NM_017504
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 246468854
    | Hs_GenLoc_end = 246469789
    | Hs_Uniprot = Q96R27
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
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    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
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'''Olfactory receptor, family 2, subfamily M, member 4''', also known as '''OR2M4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR2M4 olfactory receptor, family 2, subfamily M, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26245| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = [[Olfactory receptors]] interact with [[odorant molecules]] in the [[nose]], to initiate a [[neuronal]] response that triggers the perception of a [[smell]]. The olfactory receptor [[protein]]s are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon [[genes]]. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and [[hormone receptors]] and are responsible for the recognition and G protein-mediated transduction of [[odorant signals]]. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2M4 olfactory receptor, family 2, subfamily M, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26245| accessdate = }}</ref>
| summary_text = [[Olfactory receptors]] interact with [[odorant molecule]]s in the [[human nose|nose]], to initiate a [[neuronal]] response that triggers the perception of a [[Odor|smell]]. The olfactory receptor [[protein]]s are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon [[genes]]. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and [[hormone receptors]] and are responsible for the recognition and G protein-mediated transduction of [[odorant signals]]. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2M4 olfactory receptor, family 2, subfamily M, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26245| accessdate = }}</ref>
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Parmentier M, Libert F, Schurmans S, ''et al.'' |title=Expression of members of the putative olfactory receptor gene family in mammalian germ cells. |journal=Nature |volume=355 |issue= 6359 |pages= 453-5 |year= 1992 |pmid= 1370859 |doi= 10.1038/355453a0 }}
*{{cite journal   |vauthors=Fuchs T, Malecova B, Linhart C, etal |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295–302 |year= 2003 |pmid= 12213199 |doi=10.1006/geno.2002.6830 }}
*{{cite journal  | author=Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M |title=Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. |journal=Genomics |volume=39 |issue= 3 |pages= 239-46 |year= 1997 |pmid= 9119360 |doi= 10.1006/geno.1996.4490 }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
*{{cite journal  | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi=  }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
}}
{{refend}}
{{refend}}
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{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
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[[Category:Olfactory receptors]]

Latest revision as of 02:33, 27 October 2017

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View/Edit Human

Olfactory receptor 2M4 is a protein that in humans is encoded by the OR2M4 gene.[1][2][3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

References

  1. ↑ Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. doi:10.1038/355453a0. PMID 1370859.
  2. ↑ Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (Apr 1997). "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species". Genomics. 39 (3): 239–46. doi:10.1006/geno.1996.4490. PMID 9119360.
  3. ↑ 3.0 3.1 "Entrez Gene: OR2M4 olfactory receptor, family 2, subfamily M, member 4".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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