Nucleoporin 205: Difference between revisions
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== Function == | == Function == | ||
Transport of macromolecules between the cytoplasm and nucleus occurs through [[nuclear pore]] complexes (NPCs) embedded in the [[nuclear envelope]]. NPC's are composed of subcomplexes, and NUP205 is part of one such subcomplex.<ref name="entrez"/> | Transport of macromolecules between the cytoplasm and nucleus occurs through [[nuclear pore]] complexes (NPCs) embedded in the [[nuclear envelope]]. NPC's are composed of subcomplexes, and NUP205 is part of one such subcomplex.<ref name="entrez"/> It has also been recently shown that Nup205 is required for proper viral gene expression.<ref>Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG. Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression. J Virol. 2014 Nov;88(22):13249-59. doi: 10.1128/JVI.00933-14. Epub 2014 Sep 10. {{PMID|25210169}}; {{PMC|4249058}}.</ref> | ||
== References == | == References == | ||
| Line 14: | Line 14: | ||
* {{cite journal | vauthors = Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S | title = Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1 | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45091–8 | year = 2002 | pmid = 12228227 | doi = 10.1074/jbc.M207439200 }} | * {{cite journal | vauthors = Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S | title = Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1 | journal = J. Biol. Chem. | volume = 277 | issue = 47 | pages = 45091–8 | year = 2002 | pmid = 12228227 | doi = 10.1074/jbc.M207439200 }} | ||
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }} | * {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }} | ||
* {{cite journal | vauthors = Hase ME, Cordes VC | title = Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex | journal = Mol. Biol. Cell | volume = 14 | issue = 5 | pages = 1923–40 | year = 2003 | pmid = 12802065 | pmc = 165087 | doi = 10.1091/mbc.E02-09-0620 }} | * {{cite journal | vauthors = Hase ME, Cordes VC | title = Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex | journal = Mol. Biol. Cell | volume = 14 | issue = 5 | pages = 1923–40 | year = 2003 | pmid = 12802065 | pmc = 165087 | doi = 10.1091/mbc.E02-09-0620 | hdl = 11858/00-001M-0000-0028-3D33-F }} | ||
* {{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res. | volume = 3 | issue = 5 | pages = 321–9, 341–54 | year = 1996 | pmid = 9039502 | doi = 10.1093/dnares/3.5.321 }} | * {{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res. | volume = 3 | issue = 5 | pages = 321–9, 341–54 | year = 1996 | pmid = 9039502 | doi = 10.1093/dnares/3.5.321 }} | ||
* {{cite journal | vauthors = Sowa ME, Bennett EJ, Gygi SP, Harper JW | title = Defining the human deubiquitinating enzyme interaction landscape | journal = Cell | volume = 138 | issue = 2 | pages = 389–403 | year = 2009 | pmid = 19615732 | pmc = 2716422 | doi = 10.1016/j.cell.2009.04.042 }} | * {{cite journal | vauthors = Sowa ME, Bennett EJ, Gygi SP, Harper JW | title = Defining the human deubiquitinating enzyme interaction landscape | journal = Cell | volume = 138 | issue = 2 | pages = 389–403 | year = 2009 | pmid = 19615732 | pmc = 2716422 | doi = 10.1016/j.cell.2009.04.042 }} | ||
Latest revision as of 14:44, 4 November 2018
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
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Nucleoporin 205 (Nup205) is a protein that in humans is encoded by the NUP205 gene.[1][2][3]
Function
Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPC's are composed of subcomplexes, and NUP205 is part of one such subcomplex.[1] It has also been recently shown that Nup205 is required for proper viral gene expression.[4]
References
- ↑ 1.0 1.1 "Entrez Gene: NUP205 nucleoporin 205kDa".
- ↑ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
- ↑ Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (October 1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
- ↑ Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG. Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression. J Virol. 2014 Nov;88(22):13249-59. doi: 10.1128/JVI.00933-14. Epub 2014 Sep 10. PMID 25210169; PMC 4249058.
Further reading
- Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex". Mol. Biol. Cell. 16 (5): 2382–94. doi:10.1091/mbc.E04-10-0857. PMC 1087243. PMID 15703211.
- Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
- Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S (2002). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1". J. Biol. Chem. 277 (47): 45091–8. doi:10.1074/jbc.M207439200. PMID 12228227.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Hase ME, Cordes VC (2003). "Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex". Mol. Biol. Cell. 14 (5): 1923–40. doi:10.1091/mbc.E02-09-0620. hdl:11858/00-001M-0000-0028-3D33-F. PMC 165087. PMID 12802065.
- Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
- Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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