Nucleolin

Nucleolin
File:PBB Protein NCL image.jpg PDB rendering based on 2fc8.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2fc8​, 2fc9​
Identifiers
Symbols	NCL ; C23; FLJ45706
External IDs	Template:OMIM5 HomoloGene: 21821
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE NCL 200610 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nucleolin, also known as NCL, is a human gene.

Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.

Further reading

• Tuteja R, Tuteja N (1999). "Nucleolin: a multifunctional major nucleolar phosphoprotein". Crit. Rev. Biochem. Mol. Biol. 33 (6): 407–36. PMID 9918513.
• Pasternack MS, Bleier KJ, McInerney TN (1991). "Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro". J. Biol. Chem. 266 (22): 14703–8. PMID 1860869.CS1 maint: Multiple names: authors list (link)
• Belenguer P, Caizergues-Ferrer M, Labbé JC; et al. (1990). "Mitosis-specific phosphorylation of nucleolin by p34cdc2 protein kinase". Mol. Cell. Biol. 10 (7): 3607–18. PMID 2192260.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srivastava M, McBride OW, Fleming PJ; et al. (1990). "Genomic organization and chromosomal localization of the human nucleolin gene". J. Biol. Chem. 265 (25): 14922–31. PMID 2394707.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srivastava M, Fleming PJ, Pollard HB, Burns AL (1989). "Cloning and sequencing of the human nucleolin cDNA". FEBS Lett. 250 (1): 99–105. PMID 2737305.CS1 maint: Multiple names: authors list (link)
• Erard MS, Belenguer P, Caizergues-Ferrer M; et al. (1988). "A major nucleolar protein, nucleolin, induces chromatin decondensation by binding to histone H1". Eur. J. Biochem. 175 (3): 525–30. PMID 3409881.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tuteja N, Huang NW, Skopac D; et al. (1995). "Human DNA helicase IV is nucleolin, an RNA helicase modulated by phosphorylation". Gene. 160 (2): 143–8. PMID 7642087.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jordan P, Heid H, Kinzel V, Kübler D (1995). "Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins". Biochemistry. 33 (49): 14696–706. PMID 7993898.CS1 maint: Multiple names: authors list (link)
• Nicoloso M, Caizergues-Ferrer M, Michot B; et al. (1994). "U20, a novel small nucleolar RNA, is encoded in an intron of the nucleolin gene in mammals". Mol. Cell. Biol. 14 (9): 5766–76. PMID 8065311.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR (1993). "Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n". Mol. Cell. Biol. 13 (7): 4301–10. PMID 8321232.CS1 maint: Multiple names: authors list (link)
• Eggert M, Möws CC, Tripier D; et al. (1996). "A fraction enriched in a novel glucocorticoid receptor-interacting protein stimulates receptor-dependent transcription in vitro". J. Biol. Chem. 270 (51): 30755–9. PMID 8530516.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bharti AK, Olson MO, Kufe DW, Rubin EH (1996). "Identification of a nucleolin binding site in human topoisomerase I.". J. Biol. Chem. 271 (4): 1993–7. PMID 8567649.CS1 maint: Multiple names: authors list (link)
• Li YP, Busch RK, Valdez BC, Busch H (1996). "C23 interacts with B23, a putative nucleolar-localization-signal-binding protein". Eur. J. Biochem. 237 (1): 153–8. PMID 8620867.CS1 maint: Multiple names: authors list (link)
• Li D, Dobrowolska G, Krebs EG (1996). "The physical association of casein kinase 2 with nucleolin". J. Biol. Chem. 271 (26): 15662–8. PMID 8663258.CS1 maint: Multiple names: authors list (link)
• Zhou G, Seibenhener ML, Wooten MW (1998). "Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells". J. Biol. Chem. 272 (49): 31130–7. PMID 9388266.CS1 maint: Multiple names: authors list (link)
• Haluska P, Saleem A, Edwards TK, Rubin EH (1998). "Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen". Nucleic Acids Res. 26 (7): 1841–7. PMID 9512561.CS1 maint: Multiple names: authors list (link)
• Borggrefe T, Wabl M, Akhmedov AT, Jessberger R (1998). "A B-cell-specific DNA recombination complex". J. Biol. Chem. 273 (27): 17025–35. PMID 9642267.CS1 maint: Multiple names: authors list (link)
• Larrucea S, González-Rubio C, Cambronero R; et al. (1998). "Cellular adhesion mediated by factor J, a complement inhibitor. Evidence for nucleolin involvement". J. Biol. Chem. 273 (48): 31718–25. PMID 9822633.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Parada CA, Roeder RG (1999). "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription". EMBO J. 18 (13): 3688–701. doi:10.1093/emboj/18.13.3688. PMID 10393184.