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==Historical Perspective==
==Historical Perspective==


Non small cell lung cancer was first described by Thomas Venner of London in 1620.


==Classification==
==Classification==
Non small cell lung carcinoma may be classified into several subtypes based on the WHO histological classification system


Non small cell lung carcinoma may be classified into several subtypes based on the WHO histological classification system. The different subtypes include: Squamous cell carcinoma, adenocarcinoma, solid adenocarcinoma with mucin, adenocarcinoma with mixed subtypes, and variants
     
==Pathophysiology==
==Pathophysiology==



Revision as of 23:17, 2 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]

Overview

Non small cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC arises from the epithelial cells of the lung of the central bronchi to terminal alveoli. These tumors account for about 85% of all lung cancers.[1] As a class, NSCLC tumors are relatively insensitive to chemotherapy, compared to small cell carcinoma. When possible, they are primarily treated by surgical resection with curative intent, although chemotherapy is increasingly being used both pre-operatively (neoadjuvant chemotherapy) and post-operatively (adjuvant chemotherapy). The most common types of NSCLC are squamous cell carcinoma, large cell carcinoma, and adenocarcinoma, but there are several other types that occur less frequently, and all types can occur in unusual histologic variants and as mixed cell-type combinations.[2]

Historical Perspective

Non small cell lung cancer was first described by Thomas Venner of London in 1620.

Classification

Non small cell lung carcinoma may be classified into several subtypes based on the WHO histological classification system. The different subtypes include: Squamous cell carcinoma, adenocarcinoma, solid adenocarcinoma with mucin, adenocarcinoma with mixed subtypes, and variants

Pathophysiology

Causes

Differentiating Non Small Cell Carcinoma of the Lung from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

References

  1. http://www.cancer.org/cancer/lungcancer-non-smallcell/detailedguide/non-small-cell-lung-cancer-what-is-non-small-cell-lung-cancer
  2. "Non-small cell lung cancer treatment - National Cancer Institute". Retrieved 2008-10-19.


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