Non small cell lung cancer medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alonso Alvarado, M.D. [2] Maria Fernanda Villarreal, M.D. [3]

Overview

Chemotherapy is indicated for non-small cell lung cancer stage (> IIA, B, III) as adjuvant therapy and for I, II as first line therapy. However, the predominant therapy for non-small cell lung cancer is surgical resection. Chemotherapy and chemoradiation may be required upon histological subtype of non-small cell lung cancer.

Medical Therapy

  • Chemotherapy is indicated for early stage non-small cell lung cancer
  • Platinum-based chemotherapy (cisplatin, carboplatin, etoposide, irinotecan) are the mainstay of treatment for non-small cell lung cancer
  • Other chemotherapy regimens, such as: cyclophosphamide, doxorubicin (adriamycin), and vincristine may be an alternative for non-small cell lung cancer patients who are unable to tolerate a platinum-based chemotherapy

Complications

  • Medical therapy complications for non-small cell lung cancer will depend on the chemotherapeutic agent
  • Common chemotherapy complications, include:
  • Platinum-based chemotherapy
  • The main dose-limiting side effect of cancer treatment with platinum compounds, include:
  • Other chemotherapy complications, include:
  • Extravasation

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