Nicotine

Synonyms: L-Nicotine, Nicotine Alkaloid.

Brand Names: Black Leaf, Black Leaf 40, Campbell's Nico-Soap, Commit, Destruxol Orchid Spray, Emo-Nik, Flux Maag, Fumetobac, Habitrol, Mach-Nic, Niagara P.A. Dust, Nic-Sal, Nico-Dust, Nico-Fume, Nicocide, Nicoderm, Nicoderm Cq, Nicorette, Nicorette Plus, Nicotin, Nicotina, Nicotine Polacrilex, Nicotrol, Nicotrol Inhaler, Nicotrol Ns, Nikotin, Nikotyna, Ortho N-4 Dust, Ortho N-5 Dust, Prostep, Tendust.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Dosing and Administration

Advise patient to stop smoking completely when beginning to use smoking cessation therapy.

Nicotine gum

Adults: PO If patient smokes less than 25 cigarettes/day, chew 2 mg gum (max, 24 pieces/day) for up to 12 wk. If patient smokes at least 25 cigarettes/day, chew 4 mg gum (max, 24 pieces/day) for up to 12 wk.

Nicotine lozenges

Adults: PO If patient smokes first cigarette more than 30 min after waking up, start with the 2 mg lozenge. If patient smokes first cigarette within 30 min after waking up, start with the 4 mg lozenge. Week 1 to 6, slowly dissolve 1 lozenge in the mouth every 1 to 2 h; week 7 to 9, slowly dissolve 1 lozenge in the mouth every 2 to 4 h; week 10 to 12, slowly dissolve 1 lozenge in the mouth every 4 to 8 h.

Nicotine inhaler

Adults: Inhaler 6 to 16 cartridges/day for up to 6 mo.

Nicotine transdermal patches

Adults Habitrol: Topical If patient smokes at least 10 cigarettes/day, start with 21 mg/day for first 4 wk, then decrease dose to 14 mg/day for next 2 wk, then decrease dose to 7 mg/day for last 2 wk. If patient smokes less than 10 cigarettes/day, start with 14 mg/day for 6 wk then decrease dose to 7 mg/day for last 2 wk.

Nicoderm

Topical If patient smokes at least 10 cigarettes/day, start with 21 mg/day for first 6 wk then decrease dose to 14 mg/day for next 2 wk, then decrease dose to 7 mg/day for last 2 wk. If patient smokes less than 10 cigarettes/day, start with 14 mg/day for 6 wk then decrease dose to 7 mg/day for last 2 wk.

Nicotrol

Topical Use 15 mg/16 h for 6 wk.

Nicotine nasal spray

Adults: Spray (Each actuation delivers 50 mcL spray containing 0.5 mg nicotine.) 8 to 40 doses/day for 3 to 6 mo.

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