Nelfinavir: Difference between revisions

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==Overview==
==Overview==
'''Nelfinavir''' (brand name '''Viracept''') is an [[antiretroviral drug]] used in the treatment of the [[human immunodeficiency virus]] (HIV). Nelfinavir belongs to the class of drugs known as [[protease inhibitor (pharmacology)|protease inhibitors]] (PIs) and like other PIs is generally used in combination with other antiretroviral drugs.
Nelfinavir mesylate (Viracept, formally AG1343) is a potent and orally bioavailable human immunodeficiency virus [[HIV-1 protease]] inhibitor (Ki=2nM) and is widely prescribed in combination with [[HIV]] reverse transcriptase inhibitors for the treatment of HIV infection.<ref>{{cite journal |author=Zhang KE, Wu E, Patick AK, ''et al.'' |title=Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities |journal=Antimicrob. Agents Chemother. |volume=45 |issue=4 |pages=1086–93 |year=2001 |month=April |pmid=11257019 |pmc=90428 |doi=10.1128/AAC.45.4.1086-1093.2001 |url=}}</ref>


==Category==
==Category==

Revision as of 16:45, 9 January 2014

Nelfinavir
VIRACEPT® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages

For patient information, click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Nelfinavir (brand name Viracept) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV). Nelfinavir belongs to the class of drugs known as protease inhibitors (PIs) and like other PIs is generally used in combination with other antiretroviral drugs.

Nelfinavir mesylate (Viracept, formally AG1343) is a potent and orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor (Ki=2nM) and is widely prescribed in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.[1]

Category

Protease inhibitor

US Brand Names

VIRACEPT®

FDA Package Insert

Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Dosage and Administration | How Supplied | Labels and Packages

Mechanism of Action

Nelfinavir is an inhibitor of the HIV-1 protease. Inhibition of the viral protease prevents cleavage of the gag and gag-pol polyprotein resulting in the production of immature, non-infectious virus.[2]

References

  1. Zhang KE, Wu E, Patick AK; et al. (2001). "Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities". Antimicrob. Agents Chemother. 45 (4): 1086–93. doi:10.1128/AAC.45.4.1086-1093.2001. PMC 90428. PMID 11257019. Unknown parameter |month= ignored (help)
  2. "VIRACEPT (NELFINAVIR MESYLATE) TABLET, FILM COATED VIRACEPT (NELFINAVIR MESYLATE) POWDER [AGOURON PHARMACEUTICALS INC]". Text " accessdate" ignored (help)