NME2

Non-metastatic cells 2, protein (NM23B) expressed in
File:PBB Protein NME2 image.jpg PDB rendering based on 1be4.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1be4​, 1bhn​, 1nsk​, 1nue​
Identifiers
Symbols	NME2 ; MGC111212; NDPKB; NM23-H2; NM23B; puf
External IDs	Template:OMIM5 Template:MGI HomoloGene: 39553
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Non-metastatic cells 2, protein (NM23B) expressed in, also known as NME2, is a human gene.

Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Co-transcription of this gene and the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) which encode a fusion protein comprised of sequence sharing identity with each individual gene product.

Further reading

• Gilles AM, Presecan E, Vonica A, Lascu I (1991). "Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme". J. Biol. Chem. 266 (14): 8784–9. PMID 1851158.CS1 maint: Multiple names: authors list (link)
• Stahl JA, Leone A, Rosengard AM; et al. (1991). "Identification of a second human nm23 gene, nm23-H2". Cancer Res. 51 (1): 445–9. PMID 1988104.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rosengard AM, Krutzsch HC, Shearn A; et al. (1989). "Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development". Nature. 342 (6246): 177–80. doi:10.1038/342177a0. PMID 2509941.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Webb PA, Perisic O, Mendola CE; et al. (1995). "The crystal structure of a human nucleoside diphosphate kinase, NM23-H2". J. Mol. Biol. 251 (4): 574–87. PMID 7658474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chandrasekharappa SC, Gross LA, King SE, Collins FS (1993). "The human NME2 gene lies within 18kb of NME1 in chromosome 17". Genes Chromosomes Cancer. 6 (4): 245–8. PMID 7685630.CS1 maint: Multiple names: authors list (link)
• Ji L, Arcinas M, Boxer LM (1995). "The transcription factor, Nm23H2, binds to and activates the translocated c-myc allele in Burkitt's lymphoma". J. Biol. Chem. 270 (22): 13392–8. PMID 7768941.CS1 maint: Multiple names: authors list (link)
• MacDonald NJ, De la Rosa A, Benedict MA; et al. (1994). "A serine phosphorylation of Nm23, and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential". J. Biol. Chem. 268 (34): 25780–9. PMID 8245015.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Backer JM, Mendola CE, Kovesdi I; et al. (1993). "Chromosomal localization and nucleoside diphosphate kinase activity of human metastasis-suppressor genes NM23-1 and NM23-2". Oncogene. 8 (2): 497–502. PMID 8381224.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Postel EH, Berberich SJ, Flint SJ, Ferrone CA (1993). "Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis". Science. 261 (5120): 478–80. PMID 8392752.CS1 maint: Multiple names: authors list (link)
• Kelsell DP, Black DM, Solomon E, Spurr NK (1993). "Localization of a second NM23 gene, NME2, to chromosome 17q21-q22". Genomics. 17 (2): 522–4. doi:10.1006/geno.1993.1362. PMID 8406509.CS1 maint: Multiple names: authors list (link)
• Engel M, Véron M, Theisinger B; et al. (1996). "A novel serine/threonine-specific protein phosphotransferase activity of Nm23/nucleoside-diphosphate kinase". Eur. J. Biochem. 234 (1): 200–7. PMID 8529641.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guignard F, Markert M (1996). "The nucleoside diphosphate kinase of human neutrophils". Biochem. J. 316 ( Pt 1): 233–8. PMID 8645210.
• Moréra S, Lacombe ML, Xu Y; et al. (1996). "X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution". Structure. 3 (12): 1307–14. PMID 8747457.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Paravicini G, Steinmayr M, André E, Becker-André M (1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107.CS1 maint: Multiple names: authors list (link)
• Nosaka K, Kawahara M, Masuda M; et al. (1998). "Association of nucleoside diphosphate kinase nm23-H2 with human telomeres". Biochem. Biophys. Res. Commun. 243 (2): 342–8. doi:10.1006/bbrc.1997.8097. PMID 9480811.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pinon VP, Millot G, Munier A; et al. (1999). "Cytoskeletal association of the A and B nucleoside diphosphate kinases of interphasic but not mitotic human carcinoma cell lines: specific nuclear localization of the B subunit". Exp. Cell Res. 246 (2): 355–67. doi:10.1006/excr.1998.4318. PMID 9925751.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Negroni A, Venturelli D, Tanno B; et al. (2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roymans D, Willems R, Vissenberg K; et al. (2000). "Nucleoside diphosphate kinase beta (Nm23-R1/NDPKbeta) is associated with intermediate filaments and becomes upregulated upon cAMP-induced differentiation of rat C6 glioma". Exp. Cell Res. 261 (1): 127–38. doi:10.1006/excr.2000.5037. PMID 11082283.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baillat G, Gaillard S, Castets F, Monneron A (2002). "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I.". J. Biol. Chem. 277 (21): 18961–6. doi:10.1074/jbc.M108818200. PMID 11872741.CS1 maint: Multiple names: authors list (link)
• Fournier HN, Dupé-Manet S, Bouvard D; et al. (2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. 277 (23): 20895–902. doi:10.1074/jbc.M200200200. PMID 11919189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)