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==Interactions== | ==Interactions== | ||
NFKBIE has been shown to [[Protein-protein interaction|interact]] with [[NFKB2]],<ref name=pmid9315679>{{cite journal |last=Li |first=Z |authorlink= |author2=Nabel G J |date=October 1997 |title=A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription |journal=Mol. Cell. Biol. |volume=17 |issue=10 |pages=6184–90 |publisher= |location = United States| issn = 0270-7306| pmid = 9315679 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=232469 | doi=10.1128/mcb.17.10.6184}}</ref> [[RELA]],<ref name=pmid9315679/> [[NFKB1]]<ref name=pmid9315679/> and [[REL]].<ref name=pmid9315679/><ref name=pmid8415639>{{cite journal |last=Kumar |first=S |authorlink= |author2=Gélinas C |date=October 1993 |title=I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=90 |issue=19 |pages=8962–6 |publisher= |location = United States| issn = 0027-8424| pmid = 8415639 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.90.19.8962 |pmc=47481 }}</ref><ref name=pmid10706725>{{cite journal |last=Spiecker |first=M |authorlink= |author2=Darius H |author3=Liao J K |date=March 2000 |title=A functional role of I kappa B-epsilon in endothelial cell activation |journal=J. Immunol. |volume=164 |issue=6 |pages=3316–22 |publisher= |location = United States| issn = 0022-1767| pmid = 10706725 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | NFKBIE has been shown to [[Protein-protein interaction|interact]] with [[NFKB2]],<ref name=pmid9315679>{{cite journal |last=Li |first=Z |authorlink= |author2=Nabel G J |date=October 1997 |title=A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription |journal=Mol. Cell. Biol. |volume=17 |issue=10 |pages=6184–90 |publisher= |location = United States| issn = 0270-7306| pmid = 9315679 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=232469 | doi=10.1128/mcb.17.10.6184}}</ref> [[RELA]],<ref name=pmid9315679/> [[NFKB1]]<ref name=pmid9315679/> and [[REL]].<ref name=pmid9315679/><ref name=pmid8415639>{{cite journal |last=Kumar |first=S |authorlink= |author2=Gélinas C |date=October 1993 |title=I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=90 |issue=19 |pages=8962–6 |publisher= |location = United States| issn = 0027-8424| pmid = 8415639 | bibcode =1993PNAS...90.8962K | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.90.19.8962 |pmc=47481 }}</ref><ref name=pmid10706725>{{cite journal |last=Spiecker |first=M |authorlink= |author2=Darius H |author3=Liao J K |date=March 2000 |title=A functional role of I kappa B-epsilon in endothelial cell activation |journal=J. Immunol. |volume=164 |issue=6 |pages=3316–22 |publisher= |location = United States| issn = 0022-1767| pmid = 10706725 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | ||
==References== | ==References== | ||
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| citations = | | citations = | ||
*{{cite journal |vauthors=Hansen SK, Baeuerle PA, Blasi F |title=Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2593–603 |year= 1994 |pmid= 8139561 |doi= 10.1128/mcb.14.4.2593| pmc=358627 }} | *{{cite journal |vauthors=Hansen SK, Baeuerle PA, Blasi F |title=Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2593–603 |year= 1994 |pmid= 8139561 |doi= 10.1128/mcb.14.4.2593| pmc=358627 }} | ||
*{{cite journal |vauthors=Kumar S, Gélinas C |title=I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 19 |pages= 8962–6 |year= 1993 |pmid= 8415639 |doi=10.1073/pnas.90.19.8962 | pmc=47481 }} | *{{cite journal |vauthors=Kumar S, Gélinas C |title=I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 19 |pages= 8962–6 |year= 1993 |pmid= 8415639 |doi=10.1073/pnas.90.19.8962 | pmc=47481 |bibcode=1993PNAS...90.8962K }} | ||
*{{cite journal |vauthors=Whiteside ST, Epinat JC, Rice NR, Israël A |title=I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. |journal=EMBO J. |volume=16 |issue= 6 |pages= 1413–26 |year= 1997 |pmid= 9135156 |doi= 10.1093/emboj/16.6.1413 | pmc=1169738 }} | *{{cite journal |vauthors=Whiteside ST, Epinat JC, Rice NR, Israël A |title=I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. |journal=EMBO J. |volume=16 |issue= 6 |pages= 1413–26 |year= 1997 |pmid= 9135156 |doi= 10.1093/emboj/16.6.1413 | pmc=1169738 }} | ||
*{{cite journal |vauthors=Curristin SM, Bird KJ, Tubbs RJ, Ruddell A |title=VBP and RelA regulate avian leukosis virus long terminal repeat-enhanced transcription in B cells. |journal=J. Virol. |volume=71 |issue= 8 |pages= 5972–81 |year= 1997 |pmid= 9223487 |doi= | pmc=191853 }} | *{{cite journal |vauthors=Curristin SM, Bird KJ, Tubbs RJ, Ruddell A |title=VBP and RelA regulate avian leukosis virus long terminal repeat-enhanced transcription in B cells. |journal=J. Virol. |volume=71 |issue= 8 |pages= 5972–81 |year= 1997 |pmid= 9223487 |doi= | pmc=191853 }} | ||
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*{{cite journal |vauthors=Lee SH, Hannink M |title=Characterization of the nuclear import and export functions of Ikappa B(epsilon). |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23358–66 |year= 2002 |pmid= 11970947 |doi= 10.1074/jbc.M111559200 }} | *{{cite journal |vauthors=Lee SH, Hannink M |title=Characterization of the nuclear import and export functions of Ikappa B(epsilon). |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23358–66 |year= 2002 |pmid= 11970947 |doi= 10.1074/jbc.M111559200 }} | ||
*{{cite journal |vauthors=Bruno ME, Borchers CH, Dial JM, etal |title=Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics. |journal=Arch. Biochem. Biophys. |volume=406 |issue= 2 |pages= 153–64 |year= 2002 |pmid= 12361703 |doi=10.1016/S0003-9861(02)00452-6 }} | *{{cite journal |vauthors=Bruno ME, Borchers CH, Dial JM, etal |title=Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics. |journal=Arch. Biochem. Biophys. |volume=406 |issue= 2 |pages= 153–64 |year= 2002 |pmid= 12361703 |doi=10.1016/S0003-9861(02)00452-6 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Emmerich F, Theurich S, Hummel M, etal |title=Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. |journal=J. Pathol. |volume=201 |issue= 3 |pages= 413–20 |year= 2004 |pmid= 14595753 |doi= 10.1002/path.1454 }} | *{{cite journal |vauthors=Emmerich F, Theurich S, Hummel M, etal |title=Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. |journal=J. Pathol. |volume=201 |issue= 3 |pages= 413–20 |year= 2004 |pmid= 14595753 |doi= 10.1002/path.1454 }} | ||
*{{cite journal |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }} | *{{cite journal |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }} | ||
*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }} | ||
*{{cite journal |vauthors=Nasu-Nishimura Y, Hayashi T, Ohishi T, etal |title=Role of the Rho GTPase-activating protein RICS in neurite outgrowth. |journal=Genes Cells |volume=11 |issue= 6 |pages= 607–14 |year= 2006 |pmid= 16716191 |doi= 10.1111/j.1365-2443.2006.00966.x }} | *{{cite journal |vauthors=Nasu-Nishimura Y, Hayashi T, Ohishi T, etal |title=Role of the Rho GTPase-activating protein RICS in neurite outgrowth. |journal=Genes Cells |volume=11 |issue= 6 |pages= 607–14 |year= 2006 |pmid= 16716191 |doi= 10.1111/j.1365-2443.2006.00966.x }} | ||
*{{cite journal |vauthors=Stefansson B, Brautigan DL |title=Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. |journal=J. Biol. Chem. |volume=281 |issue= 32 |pages= 22624–34 |year= 2006 |pmid= 16769727 |doi= 10.1074/jbc.M601772200 }} | *{{cite journal |vauthors=Stefansson B, Brautigan DL |title=Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. |journal=J. Biol. Chem. |volume=281 |issue= 32 |pages= 22624–34 |year= 2006 |pmid= 16769727 |doi= 10.1074/jbc.M601772200 }} | ||
Latest revision as of 15:04, 25 June 2018
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Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.[1][2]
Function
NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins.[2]
NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see NFATC1).[1]
Interactions
NFKBIE has been shown to interact with NFKB2,[3] RELA,[3] NFKB1[3] and REL.[3][4][5]
References
- ↑ 1.0 1.1 "Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon".
- ↑ 2.0 2.1 Whiteside ST, Epinat JC, Rice NR, Israël A (March 1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738. PMID 9135156.
- ↑ 3.0 3.1 3.2 3.3 Li, Z; Nabel G J (October 1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. United States. 17 (10): 6184–90. doi:10.1128/mcb.17.10.6184. ISSN 0270-7306. PMC 232469. PMID 9315679.
- ↑ Kumar, S; Gélinas C (October 1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. United States. 90 (19): 8962–6. Bibcode:1993PNAS...90.8962K. doi:10.1073/pnas.90.19.8962. ISSN 0027-8424. PMC 47481. PMID 8415639.
- ↑ Spiecker, M; Darius H; Liao J K (March 2000). "A functional role of I kappa B-epsilon in endothelial cell activation". J. Immunol. United States. 164 (6): 3316–22. ISSN 0022-1767. PMID 10706725.
Further reading
- Hansen SK, Baeuerle PA, Blasi F (1994). "Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription". Mol. Cell. Biol. 14 (4): 2593–603. doi:10.1128/mcb.14.4.2593. PMC 358627. PMID 8139561.
- Kumar S, Gélinas C (1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 8962–6. Bibcode:1993PNAS...90.8962K. doi:10.1073/pnas.90.19.8962. PMC 47481. PMID 8415639.
- Whiteside ST, Epinat JC, Rice NR, Israël A (1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738. PMID 9135156.
- Curristin SM, Bird KJ, Tubbs RJ, Ruddell A (1997). "VBP and RelA regulate avian leukosis virus long terminal repeat-enhanced transcription in B cells". J. Virol. 71 (8): 5972–81. PMC 191853. PMID 9223487.
- Li Z, Nabel GJ (1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. 17 (10): 6184–90. doi:10.1128/mcb.17.10.6184. PMC 232469. PMID 9315679.
- Spiecker M, Darius H, Liao JK (2000). "A functional role of I kappa B-epsilon in endothelial cell activation". J. Immunol. 164 (6): 3316–22. PMID 10706725.
- Bourke E, Kennedy EJ, Moynagh PN (2001). "Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells". J. Biol. Chem. 275 (51): 39996–40002. doi:10.1074/jbc.M007693200. PMID 10998424.
- Lee SH, Hannink M (2002). "Characterization of the nuclear import and export functions of Ikappa B(epsilon)". J. Biol. Chem. 277 (26): 23358–66. doi:10.1074/jbc.M111559200. PMID 11970947.
- Bruno ME, Borchers CH, Dial JM, et al. (2002). "Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics". Arch. Biochem. Biophys. 406 (2): 153–64. doi:10.1016/S0003-9861(02)00452-6. PMID 12361703.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Emmerich F, Theurich S, Hummel M, et al. (2004). "Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells". J. Pathol. 201 (3): 413–20. doi:10.1002/path.1454. PMID 14595753.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
- Nasu-Nishimura Y, Hayashi T, Ohishi T, et al. (2006). "Role of the Rho GTPase-activating protein RICS in neurite outgrowth". Genes Cells. 11 (6): 607–14. doi:10.1111/j.1365-2443.2006.00966.x. PMID 16716191.
- Stefansson B, Brautigan DL (2006). "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon". J. Biol. Chem. 281 (32): 22624–34. doi:10.1074/jbc.M601772200. PMID 16769727.
- Chapman SJ, Khor CC, Vannberg FO, et al. (2007). "IkappaB genetic polymorphisms and invasive pneumococcal disease". Am. J. Respir. Crit. Care Med. 176 (2): 181–7. doi:10.1164/rccm.200702-169OC. PMID 17463416.
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