NFKBIE: Difference between revisions

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Latest revision as of 15:04, 25 June 2018

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.^[1]^[2]

Function

NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins.^[2]

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see NFATC1).^[1]

Interactions

NFKBIE has been shown to interact with NFKB2,^[3] RELA,^[3] NFKB1^[3] and REL.^[3]^[4]^[5]

References

↑ ^1.0 ^1.1 "Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon".
↑ ^2.0 ^2.1 Whiteside ST, Epinat JC, Rice NR, Israël A (March 1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738. PMID 9135156.
↑ ^3.0 ^3.1 ^3.2 ^3.3 Li, Z; Nabel G J (October 1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. United States. 17 (10): 6184–90. doi:10.1128/mcb.17.10.6184. ISSN 0270-7306. PMC 232469. PMID 9315679.
↑ Kumar, S; Gélinas C (October 1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. United States. 90 (19): 8962–6. Bibcode:1993PNAS...90.8962K. doi:10.1073/pnas.90.19.8962. ISSN 0027-8424. PMC 47481. PMID 8415639.
↑ Spiecker, M; Darius H; Liao J K (March 2000). "A functional role of I kappa B-epsilon in endothelial cell activation". J. Immunol. United States. 164 (6): 3316–22. ISSN 0022-1767. PMID 10706725.

Hansen SK, Baeuerle PA, Blasi F (1994). "Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription". Mol. Cell. Biol. 14 (4): 2593–603. doi:10.1128/mcb.14.4.2593. PMC 358627. PMID 8139561.
Kumar S, Gélinas C (1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. 90 (19): 8962–6. Bibcode:1993PNAS...90.8962K. doi:10.1073/pnas.90.19.8962. PMC 47481. PMID 8415639.
Whiteside ST, Epinat JC, Rice NR, Israël A (1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738. PMID 9135156.
Curristin SM, Bird KJ, Tubbs RJ, Ruddell A (1997). "VBP and RelA regulate avian leukosis virus long terminal repeat-enhanced transcription in B cells". J. Virol. 71 (8): 5972–81. PMC 191853. PMID 9223487.
Li Z, Nabel GJ (1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. 17 (10): 6184–90. doi:10.1128/mcb.17.10.6184. PMC 232469. PMID 9315679.
Spiecker M, Darius H, Liao JK (2000). "A functional role of I kappa B-epsilon in endothelial cell activation". J. Immunol. 164 (6): 3316–22. PMID 10706725.
Bourke E, Kennedy EJ, Moynagh PN (2001). "Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells". J. Biol. Chem. 275 (51): 39996–40002. doi:10.1074/jbc.M007693200. PMID 10998424.
Lee SH, Hannink M (2002). "Characterization of the nuclear import and export functions of Ikappa B(epsilon)". J. Biol. Chem. 277 (26): 23358–66. doi:10.1074/jbc.M111559200. PMID 11970947.
Bruno ME, Borchers CH, Dial JM, et al. (2002). "Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics". Arch. Biochem. Biophys. 406 (2): 153–64. doi:10.1016/S0003-9861(02)00452-6. PMID 12361703.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Emmerich F, Theurich S, Hummel M, et al. (2004). "Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells". J. Pathol. 201 (3): 413–20. doi:10.1002/path.1454. PMID 14595753.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
Nasu-Nishimura Y, Hayashi T, Ohishi T, et al. (2006). "Role of the Rho GTPase-activating protein RICS in neurite outgrowth". Genes Cells. 11 (6): 607–14. doi:10.1111/j.1365-2443.2006.00966.x. PMID 16716191.
Stefansson B, Brautigan DL (2006). "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon". J. Biol. Chem. 281 (32): 22624–34. doi:10.1074/jbc.M601772200. PMID 16769727.
Chapman SJ, Khor CC, Vannberg FO, et al. (2007). "IkappaB genetic polymorphisms and invasive pneumococcal disease". Am. J. Respir. Crit. Care Med. 176 (2): 181–7. doi:10.1164/rccm.200702-169OC. PMID 17463416.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon".

[pmid9135156-2] 2.0 ^2.1 Whiteside ST, Epinat JC, Rice NR, Israël A (March 1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity". EMBO J. 16 (6): 1413–26. doi:10.1093/emboj/16.6.1413. PMC 1169738. PMID 9135156.

[pmid9315679-3] 3.0 ^3.1 ^3.2 ^3.3 Li, Z; Nabel G J (October 1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription". Mol. Cell. Biol. United States. 17 (10): 6184–90. doi:10.1128/mcb.17.10.6184. ISSN 0270-7306. PMC 232469. PMID 9315679.

[pmid8415639-4] Kumar, S; Gélinas C (October 1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif". Proc. Natl. Acad. Sci. U.S.A. United States. 90 (19): 8962–6. Bibcode:1993PNAS...90.8962K. doi:10.1073/pnas.90.19.8962. ISSN 0027-8424. PMC 47481. PMID 8415639.

[pmid10706725-5] Spiecker, M; Darius H; Liao J K (March 2000). "A functional role of I kappa B-epsilon in endothelial cell activation". J. Immunol. United States. 164 (6): 3316–22. ISSN 0022-1767. PMID 10706725.

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[3]

[4]

[5]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Confusing|date=May 2009}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon''', also known as '''NFKBIE''', is a [[protein]] which in humans is encoded by the ''NFKBIE'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4794| accessdate = }}</ref><ref name="pmid9135156">{{cite journal |vauthors=Whiteside ST, Epinat JC, Rice NR, Israël A | title = I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity | journal = EMBO J. | volume = 16 | issue = 6 | pages = 1413–26 |date=March 1997 | pmid = 9135156 | pmc = 1169738 | doi = 10.1093/emboj/16.6.1413 | url = | issn = }}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
+== Function ==
-| update_summary = yes
-| update_citations = yes
+NFKBIE protein expression is up-regulated following [[NF-κB]] activation and during [[myelopoiesis]].  NFKBIE is able to inhibit NF-κB-directed [[transactivation]] via cytoplasmic retention of [[REL]] proteins.<ref name="pmid9135156"/>
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+[[NFKB1]] or [[NFKB2]] is bound to [[REL]], [[RELA]], or [[RELB]] to form the NF-κB [[transcription factor]] complex. The NF-κB complex is inhibited by I-kappa-B proteins ([[NFKBIA]] or [[NFKBIB]]), which inactivate NF-kappa-B by trapping it in the [[cytoplasm]]. [[Phosphorylation]] of serine residues on the I-kappa-B proteins by kinases ([[IKBKA]], or [[IKBKB]]) marks them for destruction via the [[ubiquitination]] pathway, thereby allowing activation of the NF-kappa-B complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see [[STAT6]]), [[AP-1 (transcription factor)|AP-1]] ([[C-jun|JUN]]), and NFAT (see [[NFATC1]]).<ref name="entrez"/>
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
- | HGNCid = 7799
- | Symbol = NFKBIE
- | AltSymbols =; IKBE
- | OMIM = 604548
- | ECnumber =
- | Homologene = 36160
- | MGIid = 1194908
- | GeneAtlas_image1 = PBB_GE_NFKBIE_203927_at_tn.png
- | Function =
- | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
- | Process = {{GNF_GO|id=GO:0042994 |text = cytoplasmic sequestering of transcription factor}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 4794
-    | Hs_Ensembl = ENSG00000146232
-    | Hs_RefseqProtein = NP_004547
-    | Hs_RefseqmRNA = NM_004556
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 44333881
-    | Hs_GenLoc_end = 44341503
-    | Hs_Uniprot = O00221
-    | Mm_EntrezGene = 18037
-    | Mm_Ensembl = ENSMUSG00000023947
-    | Mm_RefseqmRNA = NM_008690
-    | Mm_RefseqProtein = NP_032716
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 17
-    | Mm_GenLoc_start = 45019297
-    | Mm_GenLoc_end = 45026752
-    | Mm_Uniprot = Q3U9Q0
-  }}
-}}
-'''Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon''', also known as '''NFKBIE''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4794| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+==Interactions==
-{{PBB_Summary
+NFKBIE has been shown to [[Protein-protein interaction|interact]] with [[NFKB2]],<ref name=pmid9315679>{{cite journal |last=Li |first=Z |authorlink= |author2=Nabel G J  |date=October 1997  |title=A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription |journal=Mol. Cell. Biol. |volume=17 |issue=10 |pages=6184–90 |publisher= |location = United States| issn = 0270-7306| pmid = 9315679 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=232469 | doi=10.1128/mcb.17.10.6184}}</ref> [[RELA]],<ref name=pmid9315679/> [[NFKB1]]<ref name=pmid9315679/> and [[REL]].<ref name=pmid9315679/><ref name=pmid8415639>{{cite journal |last=Kumar |first=S |authorlink= |author2=Gélinas C  |date=October 1993  |title=I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=90 |issue=19 |pages=8962–6 |publisher= |location = United States| issn = 0027-8424| pmid = 8415639 | bibcode =1993PNAS...90.8962K | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.90.19.8962 |pmc=47481 }}</ref><ref name=pmid10706725>{{cite journal |last=Spiecker |first=M |authorlink= |author2=Darius H |author3=Liao J K  |date=March 2000  |title=A functional role of I kappa B-epsilon in endothelial cell activation |journal=J. Immunol. |volume=164 |issue=6 |pages=3316–22 |publisher= |location = United States| issn = 0022-1767| pmid = 10706725 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
-| section_title =
-| summary_text = NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT (see STAT6, MIM 601512), AP1 (JUN, MIM 165160), and NFAT (see NFATC1, MIM 600489).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4794| accessdate = }}</ref>
-}}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Hansen SK, Baeuerle PA, Blasi F |title=Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2593-603 |year= 1994 |pmid= 8139561 |doi=  }}
+*{{cite journal  |vauthors=Hansen SK, Baeuerle PA, Blasi F |title=Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2593–603 |year= 1994 |pmid= 8139561 |doi=  10.1128/mcb.14.4.2593| pmc=358627  }}
-*{{cite journal  | author=Kumar S, Gélinas C |title=I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 19 |pages= 8962-6 |year= 1993 |pmid= 8415639 |doi=  }}
+*{{cite journal  |vauthors=Kumar S, Gélinas C |title=I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 19 |pages= 8962–6 |year= 1993 |pmid= 8415639 |doi=10.1073/pnas.90.19.8962  | pmc=47481  |bibcode=1993PNAS...90.8962K }}
-*{{cite journal  | author=Whiteside ST, Epinat JC, Rice NR, Israël A |title=I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. |journal=EMBO J. |volume=16 |issue= 6 |pages= 1413-26 |year= 1997 |pmid= 9135156 |doi= 10.1093/emboj/16.6.1413 }}
+*{{cite journal  |vauthors=Whiteside ST, Epinat JC, Rice NR, Israël A |title=I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. |journal=EMBO J. |volume=16 |issue= 6 |pages= 1413–26 |year= 1997 |pmid= 9135156 |doi= 10.1093/emboj/16.6.1413  | pmc=1169738 }}
-*{{cite journal  | author=Curristin SM, Bird KJ, Tubbs RJ, Ruddell A |title=VBP and RelA regulate avian leukosis virus long terminal repeat-enhanced transcription in B cells. |journal=J. Virol. |volume=71 |issue= 8 |pages= 5972-81 |year= 1997 |pmid= 9223487 |doi=  }}
+*{{cite journal  |vauthors=Curristin SM, Bird KJ, Tubbs RJ, Ruddell A |title=VBP and RelA regulate avian leukosis virus long terminal repeat-enhanced transcription in B cells. |journal=J. Virol. |volume=71 |issue= 8 |pages= 5972–81 |year= 1997 |pmid= 9223487 |doi=  | pmc=191853  }}
-*{{cite journal  | author=Li Z, Nabel GJ |title=A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 6184-90 |year= 1997 |pmid= 9315679 |doi=  }}
+*{{cite journal  |vauthors=Li Z, Nabel GJ |title=A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. |journal=Mol. Cell. Biol. |volume=17 |issue= 10 |pages= 6184–90 |year= 1997 |pmid= 9315679 |doi=  10.1128/mcb.17.10.6184| pmc=232469  }}
-*{{cite journal  | author=Spiecker M, Darius H, Liao JK |title=A functional role of I kappa B-epsilon in endothelial cell activation. |journal=J. Immunol. |volume=164 |issue= 6 |pages= 3316-22 |year= 2000 |pmid= 10706725 |doi=  }}
+*{{cite journal  |vauthors=Spiecker M, Darius H, Liao JK |title=A functional role of I kappa B-epsilon in endothelial cell activation. |journal=J. Immunol. |volume=164 |issue= 6 |pages= 3316–22 |year= 2000 |pmid= 10706725 |doi=  }}
-*{{cite journal  | author=Bourke E, Kennedy EJ, Moynagh PN |title=Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 39996-40002 |year= 2001 |pmid= 10998424 |doi= 10.1074/jbc.M007693200 }}
+*{{cite journal  |vauthors=Bourke E, Kennedy EJ, Moynagh PN |title=Loss of Ikappa B-beta is associated with prolonged NF-kappa B activity in human glial cells. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 39996–40002 |year= 2001 |pmid= 10998424 |doi= 10.1074/jbc.M007693200 }}
-*{{cite journal  | author=Lee SH, Hannink M |title=Characterization of the nuclear import and export functions of Ikappa B(epsilon). |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23358-66 |year= 2002 |pmid= 11970947 |doi= 10.1074/jbc.M111559200 }}
+*{{cite journal  |vauthors=Lee SH, Hannink M |title=Characterization of the nuclear import and export functions of Ikappa B(epsilon). |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23358–66 |year= 2002 |pmid= 11970947 |doi= 10.1074/jbc.M111559200 }}
-*{{cite journal  | author=Bruno ME, Borchers CH, Dial JM, ''et al.'' |title=Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics. |journal=Arch. Biochem. Biophys. |volume=406 |issue= 2 |pages= 153-64 |year= 2002 |pmid= 12361703 |doi=  }}
+*{{cite journal   |vauthors=Bruno ME, Borchers CH, Dial JM, etal |title=Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics. |journal=Arch. Biochem. Biophys. |volume=406 |issue= 2 |pages= 153–64 |year= 2002 |pmid= 12361703 |doi=10.1016/S0003-9861(02)00452-6  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
-*{{cite journal  | author=Emmerich F, Theurich S, Hummel M, ''et al.'' |title=Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. |journal=J. Pathol. |volume=201 |issue= 3 |pages= 413-20 |year= 2004 |pmid= 14595753 |doi= 10.1002/path.1454 }}
+*{{cite journal   |vauthors=Emmerich F, Theurich S, Hummel M, etal |title=Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. |journal=J. Pathol. |volume=201 |issue= 3 |pages= 413–20 |year= 2004 |pmid= 14595753 |doi= 10.1002/path.1454 }}
-*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
+*{{cite journal   |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
-*{{cite journal  | author=Nasu-Nishimura Y, Hayashi T, Ohishi T, ''et al.'' |title=Role of the Rho GTPase-activating protein RICS in neurite outgrowth. |journal=Genes Cells |volume=11 |issue= 6 |pages= 607-14 |year= 2006 |pmid= 16716191 |doi= 10.1111/j.1365-2443.2006.00966.x }}
+*{{cite journal   |vauthors=Nasu-Nishimura Y, Hayashi T, Ohishi T, etal |title=Role of the Rho GTPase-activating protein RICS in neurite outgrowth. |journal=Genes Cells |volume=11 |issue= 6 |pages= 607–14 |year= 2006 |pmid= 16716191 |doi= 10.1111/j.1365-2443.2006.00966.x }}
-*{{cite journal  | author=Stefansson B, Brautigan DL |title=Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. |journal=J. Biol. Chem. |volume=281 |issue= 32 |pages= 22624-34 |year= 2006 |pmid= 16769727 |doi= 10.1074/jbc.M601772200 }}
+*{{cite journal  |vauthors=Stefansson B, Brautigan DL |title=Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. |journal=J. Biol. Chem. |volume=281 |issue= 32 |pages= 22624–34 |year= 2006 |pmid= 16769727 |doi= 10.1074/jbc.M601772200 }}
-*{{cite journal  | author=Chapman SJ, Khor CC, Vannberg FO, ''et al.'' |title=IkappaB genetic polymorphisms and invasive pneumococcal disease. |journal=Am. J. Respir. Crit. Care Med. |volume=176 |issue= 2 |pages= 181-7 |year= 2007 |pmid= 17463416 |doi= 10.1164/rccm.200702-169OC }}
+*{{cite journal   |vauthors=Chapman SJ, Khor CC, Vannberg FO, etal |title=IkappaB genetic polymorphisms and invasive pneumococcal disease. |journal=Am. J. Respir. Crit. Care Med. |volume=176 |issue= 2 |pages= 181–7 |year= 2007 |pmid= 17463416 |doi= 10.1164/rccm.200702-169OC }}
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NFKBIE: Difference between revisions

Latest revision as of 15:04, 25 June 2018

Contents

Function

Interactions

References

Further reading

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