NFATC1

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
File:PBB Protein NFATC1 image.jpg PDB rendering based on 1a66.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1a66​, 1nfa​
Identifiers
Symbols	NFATC1 ; MGC138448; NF-ATC; NFAT2; NFATc
External IDs	Template:OMIM5 Template:MGI HomoloGene: 32336
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NFATC1 209664 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1, also known as NFATC1, is a human gene.

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

See also

• NFAT

Further reading

• Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annu. Rev. Immunol. 15: 707–47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.CS1 maint: Multiple names: authors list (link)
• Crabtree GR (1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): 611–4. PMID 10089876.
• Horsley V, Pavlath GK (2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". J. Cell Biol. 156 (5): 771–4. doi:10.1083/jcb.200111073. PMID 11877454.
• Tolstrup M, Ostergaard L, Laursen AL; et al. (2004). "HIV/SIV escape from immune surveillance: focus on Nef". Curr. HIV Res. 2 (2): 141–51. PMID 15078178.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li X, Ho SN, Luna J; et al. (1995). "Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp". Cytogenet. Cell Genet. 68 (3–4): 185–91. PMID 7842733.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jabado N, Le Deist F, Fisher A, Hivroz C (1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". Eur. J. Immunol. 24 (11): 2646–52. PMID 7957556.CS1 maint: Multiple names: authors list (link)
• Vacca A, Farina M, Maroder M; et al. (1995). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochem. Biophys. Res. Commun. 205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID 7999066.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Northrop JP, Ho SN, Chen L; et al. (1994). "NF-AT components define a family of transcription factors targeted in T-cell activation". Nature. 369 (6480): 497–502. doi:10.1038/369497a0. PMID 8202141.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park J, Takeuchi A, Sharma S (1996). "Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc". J. Biol. Chem. 271 (34): 20914–21. PMID 8702849.CS1 maint: Multiple names: authors list (link)
• Di Somma MM, Majolini MB, Burastero SE; et al. (1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". Eur. J. Immunol. 26 (9): 2181–8. PMID 8814265.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beals CR, Sheridan CM, Turck CW; et al. (1997). "Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3". Science. 275 (5308): 1930–4. PMID 9072970.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kinoshita S, Su L, Amano M; et al. (1997). "The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells". Immunity. 6 (3): 235–44. PMID 9075924.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhou P, Sun LJ, Dötsch V; et al. (1998). "Solution structure of the core NFATC1/DNA complex". Cell. 92 (5): 687–96. PMID 9506523.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kinoshita S, Chen BK, Kaneshima H, Nolan GP (1998). "Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells". Cell. 95 (5): 595–604. PMID 9845362.CS1 maint: Multiple names: authors list (link)
• Chuvpilo S, Zimmer M, Kerstan A; et al. (1999). "Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells". Immunity. 10 (2): 261–9. PMID 10072078.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chuvpilo S, Avots A, Berberich-Siebelt F; et al. (1999). "Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes". J. Immunol. 162 (12): 7294–301. PMID 10358178.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang JK, Kiyokawa E, Verdin E, Trono D (2000). "The Nef protein of HIV-1 associates with rafts and primes T cells for activation". Proc. Natl. Acad. Sci. U.S.A. 97 (1): 394–9. PMID 10618429.CS1 maint: Multiple names: authors list (link)
• Porter CM, Havens MA, Clipstone NA (2000). "Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization". J. Biol. Chem. 275 (5): 3543–51. PMID 10652349.CS1 maint: Multiple names: authors list (link)

External links

• NFATC1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.