NEU3
| Sialidase 3 (membrane sialidase) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | NEU3 ; FLJ12388; SIAL3 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4847 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE NEU3 216083 s at tn.png | |||||||||||
| File:PBB GE NEU3 206948 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Sialidase 3 (membrane sialidase), also known as NEU3, is a human gene.[1]
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.[1]
References
Further reading
- Hu H, Shioda T, Moriya C; et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. PMID 8892864.
- Wada T, Yoshikawa Y, Tokuyama S; et al. (1999). "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem. Biophys. Res. Commun. 261 (1): 21–7. doi:10.1006/bbrc.1999.0973. PMID 10405317.
- Monti E, Bassi MT, Papini N; et al. (2001). "Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane". Biochem. J. 349 (Pt 1): 343–51. PMID 10861246.
- Wang Y, Yamaguchi K, Wada T; et al. (2002). "A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains". J. Biol. Chem. 277 (29): 26252–9. doi:10.1074/jbc.M110515200. PMID 12011038.
- Kakugawa Y, Wada T, Yamaguchi K; et al. (2002). "Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10718–23. doi:10.1073/pnas.152597199. PMID 12149448.
- Hart ML, Saifuddin M, Uemura K; et al. (2003). "High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1". AIDS Res. Hum. Retroviruses. 18 (17): 1311–7. doi:10.1089/088922202320886352. PMID 12487819.
- Oehler C, Kopitz J, Cantz M (2003). "Substrate specificity and inhibitor studies of a membrane-bound ganglioside sialidase isolated from human brain tissue". Biol. Chem. 383 (11): 1735–42. PMID 12530538.
- Sasaki A, Hata K, Suzuki S; et al. (2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. doi:10.1074/jbc.M212200200. PMID 12730204.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Ha KT, Lee YC, Cho SH; et al. (2004). "Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli". Mol. Cells. 17 (2): 267–73. PMID 15179041.
- Stamatos NM, Liang F, Nan X; et al. (2005). "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages". FEBS J. 272 (10): 2545–56. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103.
- Kato K, Shiga K, Yamaguchi K; et al. (2006). "Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling". Biochem. J. 394 (Pt 3): 647–56. doi:10.1042/BJ20050737. PMID 16241905.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
- Ueno S, Saito S, Wada T; et al. (2006). "Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility". J. Biol. Chem. 281 (12): 7756–64. doi:10.1074/jbc.M509668200. PMID 16428383.
- Yamaguchi K, Hata K, Wada T; et al. (2006). "Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles". Biochem. Biophys. Res. Commun. 346 (2): 484–90. doi:10.1016/j.bbrc.2006.05.136. PMID 16765317.
- Nan X, Carubelli I, Stamatos NM (2007). "Sialidase expression in activated human T lymphocytes influences production of IFN-gamma". J. Leukoc. Biol. 81 (1): 284–96. doi:10.1189/jlb.1105692. PMID 17028199.
- Yoshizumi S, Suzuki S, Hirai M; et al. (2007). "Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice". Metab. Clin. Exp. 56 (3): 420–9. doi:10.1016/j.metabol.2006.10.027. PMID 17292733.
- Wada T, Hata K, Yamaguchi K; et al. (2007). "A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells". Oncogene. 26 (17): 2483–90. doi:10.1038/sj.onc.1210341. PMID 17334392.
- Azuma Y, Sato H, Higai K, Matsumoto K (2007). "Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis". Biol. Pharm. Bull. 30 (9): 1680–4. PMID 17827720.
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