NEK6
| NIMA (never in mitosis gene a)-related kinase 6 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | NEK6 ; SID6-1512 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 49379 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
NIMA (never in mitosis gene a)-related kinase 6, also known as NEK6, is a human gene.[1]
The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.[supplied by OMIM][1]
References
Further reading
- Kobayashi T, Cohen P (1999). "Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2". Biochem. J. 339 ( Pt 2): 319–28. PMID 10191262.
- Li MZ, Yu L, Liu Q; et al. (2000). "Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3-->q34.11 by radiation hybrid mapping". Cytogenet. Cell Genet. 87 (3–4): 271–2. PMID 10702691.
- Kandli M, Feige E, Chen A; et al. (2001). "Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA". Genomics. 68 (2): 187–96. doi:10.1006/geno.2000.6293. PMID 10964517.
- Belham C, Comb MJ, Avruch J (2001). "Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase". Curr. Biol. 11 (15): 1155–67. PMID 11516946.
- Kimura M, Okano Y (2001). "Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3". Cytogenet. Cell Genet. 94 (1–2): 33–8. PMID 11701951.
- Lizcano JM, Deak M, Morrice N; et al. (2002). "Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo". J. Biol. Chem. 277 (31): 27839–49. doi:10.1074/jbc.M202042200. PMID 12023960.
- Hashimoto Y, Akita H, Hibino M; et al. (2002). "Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase". Biochem. Biophys. Res. Commun. 293 (2): 753–8. doi:10.1016/S0006-291X(02)00297-8. PMID 12054534.
- Roig J, Mikhailov A, Belham C, Avruch J (2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes Dev. 16 (13): 1640–58. doi:10.1101/gad.972202. PMID 12101123.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Matsuda A, Suzuki Y, Honda G; et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
- Belham C, Roig J, Caldwell JA; et al. (2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". J. Biol. Chem. 278 (37): 34897–909. doi:10.1074/jbc.M303663200. PMID 12840024.
- Yin MJ, Shao L, Voehringer D; et al. (2004). "The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis". J. Biol. Chem. 278 (52): 52454–60. doi:10.1074/jbc.M308080200. PMID 14563848.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Barrios-Rodiles M, Brown KR, Ozdamar B; et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Chen J, Li L, Zhang Y; et al. (2006). "Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients". Biochem. Biophys. Res. Commun. 341 (4): 1059–65. doi:10.1016/j.bbrc.2005.12.228. PMID 16476580.
- Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
- Lee EJ, Hyun SH, Chun J, Kang SS (2007). "Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins". Biochem. Biophys. Res. Commun. 358 (3): 783–8. doi:10.1016/j.bbrc.2007.04.203. PMID 17512906.
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