NEK6: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein kinase Nek6''' is an [[enzyme]] that in humans is encoded by the ''NEK6'' [[gene]].<ref name="pmid10702691">{{cite journal | vauthors = Li MZ, Yu L, Liu Q, Chu JY, Zhao SY | title = Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3→q34.11 by radiation hybrid mapping | journal = Cytogenet Cell Genet | volume = 87 | issue = 3–4 | pages = 271–2 | date = April 2000 | pmid = 10702691 | pmc =  | doi = 10.1159/000015445 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NEK6 NIMA (never in mitosis gene a)-related kinase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10783| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = NIMA (never in mitosis gene a)-related kinase 6
| HGNCid = 7749
| Symbol = NEK6
| AltSymbols =; SID6-1512
| OMIM = 604884
| ECnumber = 
| Homologene = 49379
| MGIid = 1891638
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0030071 |text = regulation of mitotic metaphase/anaphase transition}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10783
    | Hs_Ensembl = ENSG00000119408
    | Hs_RefseqProtein = NP_055212
    | Hs_RefseqmRNA = NM_014397
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 126059706
    | Hs_GenLoc_end = 126155407
    | Hs_Uniprot = Q9HC98
    | Mm_EntrezGene = 59126
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_021606
    | Mm_RefseqProtein = NP_067619
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''NIMA (never in mitosis gene a)-related kinase 6''', also known as '''NEK6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NEK6 NIMA (never in mitosis gene a)-related kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10783| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NEK6 NIMA (never in mitosis gene a)-related kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10783| accessdate = }}</ref>
}}


==References==
It is a protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.<ref>{{UniProt|Q9HC98}}</ref>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
NEK6 has been shown to [[Protein-protein interaction|interact]] with [[NEK9]].<ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name=pmid12840024>{{cite journal | vauthors = Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J | title = A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases | journal = J. Biol. Chem. | volume = 278 | issue = 37 | pages = 34897–909 | date = September 2003 | pmid = 12840024 | doi = 10.1074/jbc.M303663200 }}</ref><ref name=pmid12101123>{{cite journal | vauthors = Roig J, Mikhailov A, Belham C, Avruch J | title = Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression | journal = Genes Dev. | volume = 16 | issue = 13 | pages = 1640–58 | date = July 2002 | pmid = 12101123 | pmc = 186374 | doi = 10.1101/gad.972202 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kobayashi T, Cohen P | title = Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2 | journal = Biochem. J. | volume = 339 ( Pt 2) | issue = 2 | pages = 319–28 | year = 1999 | pmid = 10191262 | pmc = 1220160 | doi = 10.1042/0264-6021:3390319 }}
| citations =
* {{cite journal | vauthors = Kandli M, Feige E, Chen A, Kilfin G, Motro B | title = Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA | journal = Genomics | volume = 68 | issue = 2 | pages = 187–96 | year = 2001 | pmid = 10964517 | doi = 10.1006/geno.2000.6293 }}
*{{cite journal | author=Kobayashi T, Cohen P |title=Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. |journal=Biochem. J. |volume=339 ( Pt 2) |issue= |pages= 319-28 |year= 1999 |pmid= 10191262 |doi= }}
* {{cite journal | vauthors = Belham C, Comb MJ, Avruch J | title = Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase | journal = Curr. Biol. | volume = 11 | issue = 15 | pages = 1155–67 | year = 2001 | pmid = 11516946 | doi = 10.1016/S0960-9822(01)00369-4 }}
*{{cite journal  | author=Li MZ, Yu L, Liu Q, ''et al.'' |title=Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3-->q34.11 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 271-2 |year= 2000 |pmid= 10702691 |doi=  }}
* {{cite journal | vauthors = Kimura M, Okano Y | title = Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3 | journal = Cytogenet. Cell Genet. | volume = 94 | issue = 1–2 | pages = 33–8 | year = 2001 | pmid = 11701951 | doi = 10.1159/000048779 }}
*{{cite journal | author=Kandli M, Feige E, Chen A, ''et al.'' |title=Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. |journal=Genomics |volume=68 |issue= 2 |pages= 187-96 |year= 2001 |pmid= 10964517 |doi= 10.1006/geno.2000.6293 }}
* {{cite journal | vauthors = Lizcano JM, Deak M, Morrice N, Kieloch A, Hastie CJ, Dong L, Schutkowski M, Reimer U, Alessi DR | title = Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo | journal = J. Biol. Chem. | volume = 277 | issue = 31 | pages = 27839–49 | year = 2002 | pmid = 12023960 | doi = 10.1074/jbc.M202042200 }}
*{{cite journal | author=Belham C, Comb MJ, Avruch J |title=Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. |journal=Curr. Biol. |volume=11 |issue= 15 |pages= 1155-67 |year= 2001 |pmid= 11516946 |doi= }}
* {{cite journal | vauthors = Hashimoto Y, Akita H, Hibino M, Kohri K, Nakanishi M | title = Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 2 | pages = 753–8 | year = 2002 | pmid = 12054534 | doi = 10.1016/S0006-291X(02)00297-8 }}
*{{cite journal | author=Kimura M, Okano Y |title=Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3. |journal=Cytogenet. Cell Genet. |volume=94 |issue= 1-2 |pages= 33-8 |year= 2001 |pmid= 11701951 |doi= }}
* {{cite journal | vauthors = Roig J, Mikhailov A, Belham C, Avruch J | title = Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression | journal = Genes Dev. | volume = 16 | issue = 13 | pages = 1640–58 | year = 2002 | pmid = 12101123 | pmc = 186374 | doi = 10.1101/gad.972202 }}
*{{cite journal | author=Lizcano JM, Deak M, Morrice N, ''et al.'' |title=Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27839-49 |year= 2002 |pmid= 12023960 |doi= 10.1074/jbc.M202042200 }}
* {{cite journal | vauthors = Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S | title = Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways | journal = Oncogene | volume = 22 | issue = 21 | pages = 3307–18 | year = 2003 | pmid = 12761501 | doi = 10.1038/sj.onc.1206406 }}
*{{cite journal | author=Hashimoto Y, Akita H, Hibino M, ''et al.'' |title=Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 2 |pages= 753-8 |year= 2002 |pmid= 12054534 |doi= 10.1016/S0006-291X(02)00297-8 }}
* {{cite journal | vauthors = Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J | title = A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases | journal = J. Biol. Chem. | volume = 278 | issue = 37 | pages = 34897–909 | year = 2003 | pmid = 12840024 | doi = 10.1074/jbc.M303663200 }}
*{{cite journal | author=Roig J, Mikhailov A, Belham C, Avruch J |title=Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. |journal=Genes Dev. |volume=16 |issue= 13 |pages= 1640-58 |year= 2002 |pmid= 12101123 |doi= 10.1101/gad.972202 }}
* {{cite journal | vauthors = Yin MJ, Shao L, Voehringer D, Smeal T, Jallal B | title = The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis | journal = J. Biol. Chem. | volume = 278 | issue = 52 | pages = 52454–60 | year = 2004 | pmid = 14563848 | doi = 10.1074/jbc.M308080200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | year = 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 }}
*{{cite journal  | author=Matsuda A, Suzuki Y, Honda G, ''et al.'' |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307-18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 }}
* {{cite journal | vauthors = Chen J, Li L, Zhang Y, Yang H, Wei Y, Zhang L, Liu X, Yu L | title = Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients | journal = Biochem. Biophys. Res. Commun. | volume = 341 | issue = 4 | pages = 1059–65 | year = 2006 | pmid = 16476580 | doi = 10.1016/j.bbrc.2005.12.228 }}
*{{cite journal | author=Belham C, Roig J, Caldwell JA, ''et al.'' |title=A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 34897-909 |year= 2003 |pmid= 12840024 |doi= 10.1074/jbc.M303663200 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Yin MJ, Shao L, Voehringer D, ''et al.'' |title=The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52454-60 |year= 2004 |pmid= 14563848 |doi= 10.1074/jbc.M308080200 }}
* {{cite journal | vauthors = Lee EJ, Hyun SH, Chun J, Kang SS | title = Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins | journal = Biochem. Biophys. Res. Commun. | volume = 358 | issue = 3 | pages = 783–8 | year = 2007 | pmid = 17512906 | doi = 10.1016/j.bbrc.2007.04.203 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Chen J, Li L, Zhang Y, ''et al.'' |title=Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 4 |pages= 1059-65 |year= 2006 |pmid= 16476580 |doi= 10.1016/j.bbrc.2005.12.228 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal | author=Lee EJ, Hyun SH, Chun J, Kang SS |title=Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins. |journal=Biochem. Biophys. Res. Commun. |volume=358 |issue= 3 |pages= 783-8 |year= 2007 |pmid= 17512906 |doi= 10.1016/j.bbrc.2007.04.203 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Human proteins]]
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{{gene-9-stub}}

Latest revision as of 12:49, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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View/Edit Human

Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene.[1][2]

Function

The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.[2]

It is a protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.[3]

Interactions

NEK6 has been shown to interact with NEK9.[4][5][6]

References

  1. ↑ Li MZ, Yu L, Liu Q, Chu JY, Zhao SY (April 2000). "Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3→q34.11 by radiation hybrid mapping". Cytogenet Cell Genet. 87 (3–4): 271–2. doi:10.1159/000015445. PMID 10702691.
  2. ↑ 2.0 2.1 "Entrez Gene: NEK6 NIMA (never in mitosis gene a)-related kinase 6".
  3. ↑ Q9HC98
  4. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  5. ↑ Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J (September 2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". J. Biol. Chem. 278 (37): 34897–909. doi:10.1074/jbc.M303663200. PMID 12840024.
  6. ↑ Roig J, Mikhailov A, Belham C, Avruch J (July 2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes Dev. 16 (13): 1640–58. doi:10.1101/gad.972202. PMC 186374. PMID 12101123.

Further reading


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