NDRG4: Difference between revisions

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{{Infobox_gene}}
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'''Protein NDRG4''' is a [[protein]] that in humans is encoded by the ''NDRG4'' [[gene]].<ref name="pmid11352569">{{cite journal |vauthors=Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T | title = Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart | journal = Genomics | volume = 73 | issue = 1 | pages = 86–97 |date=May 2001 | pmid = 11352569 | pmc =  | doi = 10.1006/geno.2000.6496 }}</ref><ref name="pmid16408304">{{cite journal |vauthors=Hongo S, Watanabe T, Takahashi K, Miyazaki A | title = Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation | journal = J Cell Biochem | volume = 98 | issue = 1 | pages = 185–93 |date=Apr 2006 | pmid = 16408304 | pmc =  | doi = 10.1002/jcb.20763 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NDRG4 NDRG family member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65009| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = NDRG family member 4
| HGNCid = 14466
| Symbol = NDRG4
| AltSymbols =; DKFZp686I1615; FLJ30586; FLJ42011; KIAA1180; MGC19632; SMAP-8
| OMIM =
| ECnumber =
| Homologene = 23228
| MGIid = 2384590
  | GeneAtlas_image1 = PBB_GE_NDRG4_209159_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}  
| Process = {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016049 |text = cell growth}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 65009
    | Hs_Ensembl = ENSG00000103034
    | Hs_RefseqProtein = NP_065198
    | Hs_RefseqmRNA = NM_020465
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 57055118
    | Hs_GenLoc_end = 57105023
    | Hs_Uniprot = Q9ULP0
    | Mm_EntrezGene = 234593
    | Mm_Ensembl = ENSMUSG00000036564
    | Mm_RefseqmRNA = NM_145602
    | Mm_RefseqProtein = NP_663577
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 98567215
    | Mm_GenLoc_end = 98604248
    | Mm_Uniprot = Q8BTG7
  }}
}}
'''NDRG family member 4''', also known as '''NDRG4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NDRG4 NDRG family member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65009| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: NDRG4 NDRG family member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65009| accessdate = }}</ref>
| summary_text = This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta [[hydrolase]] superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of [[Mitogen|mitogenic]] signalling in vascular [[smooth muscles]] cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | author=Nakajima D |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99  |name-list-format=vanc| author2=Okazaki N  | author3=Yamakawa H  | display-authors=3  | last4=Kikuno  | first4=R  | last5=Ohara  | first5=O  | last6=Nagase  | first6=T }}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |name-list-format=vanc| author2=Wentland MA  | author3=Ricafrente JY  | display-authors=3  | last4=Liu  | first4=W  | last5=Gibbs  | first5=RA }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | author=Yu W |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146  |name-list-format=vanc| author2=Andersson B  | author3=Worley KC  | display-authors=3  | last4=Muzny  | first4=DM  | last5=Ding  | first5=Y  | last6=Liu  | first6=W  | last7=Ricafrente  | first7=JY  | last8=Wentland  | first8=MA  | last9=Lennon  | first9=G }}
*{{cite journal  | author=Hirosawa M, Nagase T, Ishikawa K, ''et al.'' |title=Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=6 |issue= 5 |pages= 329-36 |year= 2000 |pmid= 10574461 |doi=  }}
*{{cite journal  | author=Hirosawa M |title=Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain |journal=DNA Res. |volume=6 |issue= 5 |pages= 329–36 |year= 2000 |pmid= 10574461 |doi=10.1093/dnares/6.5.329  |name-list-format=vanc| author2=Nagase T  | author3=Ishikawa K  | display-authors=3  | last4=Kikuno  | first4=R  | last5=Nomura  | first5=N  | last6=Ohara  | first6=O }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | author=Wiemann S |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072  |name-list-format=vanc| author2=Weil B  | author3=Wellenreuther R  | display-authors=3  | last4=Gassenhuber  | first4=J  | last5=Glassl | first5=S  | last6=Ansorge  | first6=W  | last7=Böcher  | first7=M  | last8=Blöcker  | first8=H  | last9=Bauersachs  | first9=S }}
*{{cite journal | author=Zhou RH, Kokame K, Tsukamoto Y, ''et al.'' |title=Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. |journal=Genomics |volume=73 |issue= 1 |pages= 86-97 |year= 2001 |pmid= 11352569 |doi= 10.1006/geno.2000.6496 }}
*{{cite journal  | author=Qu X |title=Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family |journal=Mol. Cell. Biochem. |volume=229 |issue= 1–2 |pages= 35–44 |year= 2002 |pmid= 11936845 |doi=10.1023/A:1017934810825  |name-list-format=vanc| author2=Zhai Y  | author3=Wei H  | display-authors=3  | last4=Zhang  | first4=Chenggang  | last5=Xing  | first5=Guichun  | last6=Yu  | first6=Yongtao  | last7=He  | first7=Fuchu }}
*{{cite journal  | author=Qu X, Zhai Y, Wei H, ''et al.'' |title=Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. |journal=Mol. Cell. Biochem. |volume=229 |issue= 1-2 |pages= 35-44 |year= 2002 |pmid= 11936845 |doi=  }}
*{{cite journal  | author=Ohki T |title=Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells |journal=Brain Res. Dev. Brain Res. |volume=135 |issue= 1–2 |pages= 55–63 |year= 2002 |pmid= 11978393 |doi=10.1016/S0165-3806(02)00300-0  |name-list-format=vanc| author2=Hongo S  | author3=Nakada N  | display-authors=3  | last4=Maeda  | first4=A  | last5=Takeda  | first5=M }}
*{{cite journal  | author=Ohki T, Hongo S, Nakada N, ''et al.'' |title=Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells. |journal=Brain Res. Dev. Brain Res. |volume=135 |issue= 1-2 |pages= 55-63 |year= 2002 |pmid= 11978393 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Nishimoto S |title=A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells |journal=Eur. J. Biochem. |volume=270 |issue= 11 |pages= 2521–31 |year= 2003 |pmid= 12755708 |doi=10.1046/j.1432-1033.2003.03626.x  |name-list-format=vanc| author2=Tawara J  | author3=Toyoda H  | display-authors=3  | last4=Kitamura  | first4=Kunihiro  | last5=Komurasaki  | first5=Toshi }}
*{{cite journal  | author=Nishimoto S, Tawara J, Toyoda H, ''et al.'' |title=A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells. |journal=Eur. J. Biochem. |volume=270 |issue= 11 |pages= 2521-31 |year= 2003 |pmid= 12755708 |doi=  }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501  |name-list-format=vanc| author2=Rosenfelder H  | author3=Schupp I  | display-authors=3  | last4=Del Val  | first4=C  | last5=Arlt  | first5=D  | last6=Hahne  | first6=F  | last7=Bechtel  | first7=S  | last8=Simpson  | first8=J | last9=Hofmann  | first9=O }}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Hongo S, Watanabe T, Takahashi K, Miyazaki A |title=Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation. |journal=J. Cell. Biochem. |volume=98 |issue= 1 |pages= 185-93 |year=  |pmid= 16408304 |doi= 10.1002/jcb.20763 }}
}}
}}
{{refend}}
{{refend}}


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[[Category:Human proteins]]
 
 
{{gene-16-stub}}

Latest revision as of 09:19, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene.[1][2][3]

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[3]

References

  1. ↑ Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T (May 2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". Genomics. 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569.
  2. ↑ Hongo S, Watanabe T, Takahashi K, Miyazaki A (Apr 2006). "Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation". J Cell Biochem. 98 (1): 185–93. doi:10.1002/jcb.20763. PMID 16408304.
  3. ↑ 3.0 3.1 "Entrez Gene: NDRG4 NDRG family member 4".

Further reading


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