NDN (gene)

Necdin homolog (mouse)
Identifiers
Symbols	NDN ; HsT16328
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20559
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NDN 209550 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Necdin homolog (mouse), also known as NDN, is a human gene.

This intronless gene is located in the Prader-Willi syndrome (PWS) deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons.

Further reading

• Aizawa T, Maruyama K, Kondo H, Yoshikawa K (1992). "Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain". Brain Res. Dev. Brain Res. 68 (2): 265–74. PMID 1394972.CS1 maint: Multiple names: authors list (link)
• MacDonald HR, Wevrick R (1998). "The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse". Hum. Mol. Genet. 6 (11): 1873–8. PMID 9302265.
• Jay P, Rougeulle C, Massacrier A; et al. (1997). "The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region". Nat. Genet. 17 (3): 357–61. doi:10.1038/ng1197-357. PMID 9354807.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taniura H, Taniguchi N, Hara M, Yoshikawa K (1998). "Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1". J. Biol. Chem. 273 (2): 720–8. PMID 9422723.CS1 maint: Multiple names: authors list (link)
• Nakada Y, Taniura H, Uetsuki T; et al. (1998). "The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region". Gene. 213 (1–2): 65–72. PMID 9630521.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Taniura H, Matsumoto K, Yoshikawa K (1999). "Physical and functional interactions of neuronal growth suppressor necdin with p53". J. Biol. Chem. 274 (23): 16242–8. PMID 10347180.CS1 maint: Multiple names: authors list (link)
• Taniguchi N, Taniura H, Niinobe M; et al. (2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". J. Biol. Chem. 275 (41): 31674–81. doi:10.1074/jbc.M005103200. PMID 10915798.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Niinobe M, Koyama K, Yoshikawa K (2000). "Cellular and subcellular localization of necdin in fetal and adult mouse brain". Dev. Neurosci. 22 (4): 310–9. PMID 10965153.CS1 maint: Multiple names: authors list (link)
• Taniura H, Yoshikawa K (2002). "Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix". J. Cell. Biochem. 84 (3): 545–55. PMID 11813259.
• Sasaki A, Masuda Y, Iwai K; et al. (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi M, Taniura H, Yoshikawa K (2003). "Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells". J. Biol. Chem. 277 (44): 42128–35. doi:10.1074/jbc.M205024200. PMID 12198120.CS1 maint: Multiple names: authors list (link)
• Tcherpakov M, Bronfman FC, Conticello SG; et al. (2003). "The p75 neurotrophin receptor interacts with multiple MAGE proteins". J. Biol. Chem. 277 (51): 49101–4. doi:10.1074/jbc.C200533200. PMID 12414813.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bronfman FC, Tcherpakov M, Jovin TM, Fainzilber M (2003). "Ligand-induced internalization of the p75 neurotrophin receptor: a slow route to the signaling endosome". J. Neurosci. 23 (8): 3209–20. PMID 12716928.CS1 maint: Multiple names: authors list (link)
• Hu B, Wang S, Zhang Y; et al. (2003). "A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 10008–13. doi:10.1073/pnas.1737765100. PMID 12913118.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuwako K, Taniura H, Yoshikawa K (2004). "Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor". J. Biol. Chem. 279 (3): 1703–12. doi:10.1074/jbc.M308454200. PMID 14593116.CS1 maint: Multiple names: authors list (link)
• Lau JC, Hanel ML, Wevrick R (2004). "Tissue-specific and imprinted epigenetic modifications of the human NDN gene". Nucleic Acids Res. 32 (11): 3376–82. doi:10.1093/nar/gkh671. PMID 15247330.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moon HE, Ahn MY, Park JA; et al. (2005). "Negative regulation of hypoxia inducible factor-1alpha by necdin". FEBS Lett. 579 (17): 3797–801. doi:10.1016/j.febslet.2005.05.072. PMID 15978586.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)