Myeloproliferative neoplasm laboratory findings: Difference between revisions

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Laboratory findings consistent with the diagnosis of myeloproliferative neoplasm include [[leukocytosis]], [[thrombocytopenia]], and [[anemia]].
Laboratory findings consistent with the diagnosis of myeloproliferative neoplasm include [[leukocytosis]], [[thrombocytopenia]], and [[anemia]].
==Laboratory Findings==
==Laboratory Findings==
Laboratory findings associated with chronic myelogenous leukemia include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref>
Laboratory findings associated with chronic myelogenous leukemia include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab</ref><ref>{{Cite journal
<ref>{{Cite journal
  | author = [[James W. Vardiman]]
  | author = [[James W. Vardiman]]
  | title = Chronic myelogenous leukemia, BCR-ABL1+
  | title = Chronic myelogenous leukemia, BCR-ABL1+
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::*Inversions
::*Inversions
::*loss or gain of a chromosome number
::*loss or gain of a chromosome number
*Fluorescent in situ hybridization (FISH)
*[[Fluorescent in situ hybridization]] (FISH)
:*Similar to cytogenetics, but more specific
:*Similar to cytogenetics, but more specific
*Polymerase chain reaction
*Polymerase chain reaction

Revision as of 14:12, 26 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

Laboratory findings consistent with the diagnosis of myeloproliferative neoplasm include leukocytosis, thrombocytopenia, and anemia.

Laboratory Findings

Laboratory findings associated with chronic myelogenous leukemia include:[1][2][3]

  • Blood chemistry
  • The following blood levels may be elevated:
  • Bleeding and clotting factor
  • The following blood levels may be elevated:
  • Cytochemistry helps determine the type of cells that are present
  • Flow cytometry helps determine the type of cells that are present
  • Chromosome changes that may occur in some people with leukemia include:
  • Similar to cytogenetics, but more specific
  • Polymerase chain reaction
  • Helpful to detect specific abnormalities in blood or bone marrow cells. Abnormalities can be found even if very few leukemia cells are present in a tissue sample.


  • Red cell mass determination (for polycythaemia)
  • Neutrophil alkaline phosphatase level
  • Vitamin B12 (or B12 binding capacity)
  • Serum urate.[4]

References

  1. Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab
  2. James W. Vardiman (2009). "Chronic myelogenous leukemia, BCR-ABL1+". American journal of clinical pathology. 132 (2): 250–260. doi:10.1309/AJCPUN89CXERVOVH. PMID 19605820. Unknown parameter |month= ignored (help)
  3. Sánchez-Muñoz, Laura; Alvarez-Twose, Ivan; García-Montero, Andrés C; Teodosio, Cristina; Jara-Acevedo, María; Pedreira, Carlos E; Matito, Almudena; Morgado, Jose Mario T; Sánchez, Maria Luz; Mollejo, Manuela; Gonzalez-de-Olano, David; Orfao, Alberto; Escribano, Luis (2011). "Evaluation of the WHO criteria for the classification of patients with mastocytosis". Modern Pathology. 24 (9): 1157–1168. doi:10.1038/modpathol.2011.84. ISSN 0893-3952.
  4. Levene, Malcolm I.; Lewis, S. M.; Bain, Barbara J.; Imelda Bates. Dacie & Lewis Practical Haematology. London: W B Saunders. p. 586. ISBN 0-443-06377-X.

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