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__NOTOC__
'''For patient information, click [[Myelodysplastic syndrome (patient information)|here]]'''
'''For patient information, click [[Myelodysplastic syndrome (patient information)|here]]'''
{{Myelodysplastic syndrome}}
{{CMG}}; {{AE}} {{NM}} {{ADS}}


{{Infobox_Disease |
{{SK}} Preleukemia syndrome; dysmyelopoietic syndrome; myelodysplasia; refractory anaemia; refractory anemia
  Name          = {{PAGENAME}} |
  Image          = |
  Caption        = |
  DiseasesDB    = 8604|
  ICD10          = {{ICD10|D|46||d|37}} |
  ICD9          = {{ICD9|238.7}} |
  ICDO          = 9980/0-9989/3 |
  OMIM          = |
  MedlinePlus    = |
  MeshID        = D009190 |
}}
{{Myelodysplastic syndrome}}
{{CMG}}


==[[Myelodysplastic syndrome overview|Overview]]==
==[[Myelodysplastic syndrome overview|Overview]]==
==[[Myelodysplastic syndrome historical perspective|Historical Perspective]]==


==[[Myelodysplastic syndrome classification|Classification]]==
==[[Myelodysplastic syndrome classification|Classification]]==


==[[Myelodysplastic syndrome historical perspective|Historical Perspective]]==
==[[Myelodysplastic syndrome pathophysiology|Pathophysiology]]==
 
==[[Myelodysplastic syndrome causes|Causes]]==


==[[Myelodysplastic syndrome pathophysiology|Pathophysiology]]==
==[[Myelodysplastic syndrome differential diagnosis|Differentiating Myelodysplastic syndrome from other Diseases]]==
====[[Myelodysplastic syndrome genetics|Genetics]]====


==[[Myelodysplastic syndrome epidemiology and demographics|Epidemiology & Demographics]]==
==[[Myelodysplastic syndrome epidemiology and demographics|Epidemiology & Demographics]]==


==[[Myelodysplastic syndrome epidemiology and demographics|Risk Factors]]==
==[[Myelodysplastic syndrome risk factors|Risk Factors]]==


==[[Myelodysplastic syndrome screening|Screening]]==
==[[Myelodysplastic syndrome screening|Screening]]==


==[[Myelodysplastic syndrome causes|Causes]]==
==[[Myelodysplastic syndrome natural history, complications and prognosis|Natural History, Complications & Prognosis]]==


==[[Myelodysplastic syndrome differential diagnosis|Differentiating Myelodysplastic syndrome from other Diseases]]==
==Diagnosis==
[[Myelodysplastic syndrome history and symptoms|History and Symptoms]] | [[Myelodysplastic syndrome physical examination|Physical Examination]] | [[Myelodysplastic syndrome laboratory findings|Laboratory Findings]] | [[Myelodysplastic syndrome electrocardiogram|Electrocardiogram]] | [[Myelodysplastic syndrome chest x ray|Chest X Ray]] | [[Myelodysplastic syndrome CT|CT]] | [[Myelodysplastic syndrome MRI|MRI]]  | [[Myelodysplastic syndrome other imaging findings|Other Imaging Findings]] | [[Myelodysplastic syndrome other diagnostic studies|Other Diagnostic Studies]]


==[[Myelodysplastic syndrome natural history|Natural History, Complications & Prognosis]]==
==Treatment==
[[Myelodysplastic syndrome medical therapy|Medical Therapy]] | [[Myelodysplastic syndrome surgery|Surgery]] | [[Myelodysplastic syndrome primary prevention|Primary Prevention]] | [[Myelodysplastic syndrome secondary prevention|Secondary Prevention]] | [[Myelodysplastic syndrome cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Myelodysplastic syndrome future or investigational therapies|Future or Investigational Therapies]]


==Diagnosis==
==Case Studies==
[[Myelodysplastic syndrome history and symptoms|History & Symptoms]] | [[Myelodysplastic syndrome physical examination|Physical Examination]] | [[Myelodysplastic syndrome staging|Staging]] | [[Myelodysplastic syndrome laboratory tests|Lab Tests]] | [[Myelodysplastic syndrome electrocardiogram|Electrocardiogram]] | [[Myelodysplastic syndrome chest x ray|Chest X Ray]] | [[Myelodysplastic syndrome CT|CT]] | [[Myelodysplastic syndrome MRI|MRI]] | [[Myelodysplastic syndrome echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Myelodysplastic syndrome other imaging findings|Other Imaging Findings]] | [[Myelodysplastic syndrome other diagnostic studies|Other Diagnostic Studies]]


==Treatment==
[[Myelodysplastic syndrome case study one|Case #1]]
[[Myelodysplastic syndrome medical therapy|Medical Therapy]] | [[Myelodysplastic syndrome surgery|Surgery]] | [[Myelodysplastic syndrome primary prevention|Primary Prevention]] | [[Myelodysplastic syndrome secondary prevention|Secondary Prevention]]  


==Related chapters==
==Related chapters==
*[[Myelodysplastic syndrome genetics]]
*[[Myelodysplastic syndrome staging]]
*[[Myeloproliferative syndrome]]
*[[Myeloproliferative syndrome]]
*[[Acute myeloid leukemia]]
*[[Acute myeloid leukemia]]
*[[Chloroma]]
*[[Chloroma]]


==Additional Readings==
* Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C. ''Proposals for the classification of the myelodysplastic syndromes.'' Br J Haematol 1982;51:189. PMID 6952920.
* Block M, Jacobson LO, Bethard WF. ''Preleukemic acute human leukemia.'' [[Journal of the American Medical Association|JAMA]] 1953;152:1018-28. PMID 13052490.
* Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD. ''World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997.'' J Clin Oncol 1999;17:3835-49. PMID 10577857.
* Foucar, K Bone Marrow Pathology, 2nd Edition, ASCP Press.  c 2001
* Greenberg, Peter L. (editor) "Myelodysplastic Syndromes: Clinical and Biological Advances" Cambridge University Press, New York 2006 ISBN 978-0521496681 ISBN 0521496683
* Steensma DP, Gibbons RJ, Higgs DR. "Acquired alpha-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies." Blood 2005;105:443-452. PMID 15358626. 
* List A, Dewald G, Bennett J, Giagnounidis A, Raza A, Feldman E, Powell B, Greenberg P, Thomas D, Store R, Reeder C, Wride K, Patin J, Schmidt M, Zeldis J, Knight R. "Lenalidomide in the Myelodysplastic Syndrome with Chromosome 5q Deletion." NEJM 2006;355(14):1456-1465. PMID 17021321.
* Fenaux P, Mufti GJ, Lindberg EH, Santini V, Finelli C, Giagounidis A, Schoch R, Gatterman N, Sanz G, List A, Gore SD, Seymour JF, Bennett JM, Byrd J, Backstrum J, Zimmerman JF, McKenzie D, Beach CL, Silverman LR. "Efficacy of Azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised open-label phase III study." Lancet Oncology 2009;10(3):223-232. PMID 19230772. 
==Resources==
* ''[http://www.ncbi.nlm.nih.gov:80/books/bv.fcgi?rid=cmed.chapter.32804 Cancer Medicine]''. Online textbook. Chapter by Lewis R. Silverman on Myelodysplastic Syndrome.
* [http://www.mayoclinic.com/print/myelodysplastic-syndromes/DS00596/DSECTION=all&METHOD=print Myelodysplastic syndromes]. Comprehensive article from MayoClinic.com.
* [http://www.va.gov/vetapp04/files4/0434293.txt] Agent Orange and MDS, 100% service connected.


{{Hematology}}
{{Hematological malignancy histology}}
{{SIB}}
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[[Category:Mature chapter]]
[[Category:Mature chapter]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Neurology]]
[[Category:Neurosurgery]]

Latest revision as of 03:26, 20 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2] Amandeep Singh M.D.[3]

Synonyms and keywords: Preleukemia syndrome; dysmyelopoietic syndrome; myelodysplasia; refractory anaemia; refractory anemia

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Myelodysplastic syndrome from other Diseases

Epidemiology & Demographics

Risk Factors

Screening

Natural History, Complications & Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Chest X Ray | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Related chapters


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