Difference between revisions of "Myd88"

Jump to: navigation, search
 
m (1 revision(s))
 
(2 intermediate revisions by 2 users not shown)
Line 1: Line 1:
{{protein
+
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
|Name=myeloid differentiation primary response gene (88)
+
{{PBB_Controls
|caption=
+
| update_page = yes
|image=
+
| require_manual_inspection = no
|width=
+
| update_protein_box = yes
|HGNCid=7562
+
| update_summary = no
|Symbol=MYD88
+
| update_citations = yes
|AltSymbols=
 
|EntrezGene=4615
 
|OMIM=602170
 
|RefSeq=NM_002468
 
|UniProt=Q99836
 
|PDB=
 
|ECnumber=
 
|Chromosome=3
 
|Arm=p
 
|Band=22
 
|LocusSupplementaryData=
 
 
}}
 
}}
'''MyD88'''-a universal [[adapter protein]] as it is used by all [[toll-like receptor|TLR]]s (except [[TLR 3]]) to activate [[transcription factor]] [[Nfkappa B]]. Mal is necessary to recruit Myd88 to [[TLR 2]] and [[TLR 4]]. TLRs can use Myd88 dependent and independent pathways.
+
 
 +
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 +
{{GNF_Protein_box
 +
| image = 
 +
| image_source = 
 +
| PDB =
 +
| Name = Myeloid differentiation primary response gene (88)
 +
| HGNCid = 7562
 +
| Symbol = MYD88
 +
| AltSymbols =;
 +
| OMIM = 602170
 +
| ECnumber = 
 +
| Homologene = 1849
 +
| MGIid = 108005
 +
| GeneAtlas_image1 = PBB_GE_MYD88_209124_at_tn.png
 +
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005123 |text = death receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
 +
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
 +
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0016064 |text = immunoglobulin mediated immune response}} {{GNF_GO|id=GO:0042535 |text = positive regulation of tumor necrosis factor biosynthetic process}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0045351 |text = interferon type I biosynthetic process}}
 +
| Orthologs = {{GNF_Ortholog_box
 +
    | Hs_EntrezGene = 4615
 +
    | Hs_Ensembl = ENSG00000172936
 +
    | Hs_RefseqProtein = NP_002459
 +
    | Hs_RefseqmRNA = NM_002468
 +
    | Hs_GenLoc_db = 
 +
    | Hs_GenLoc_chr = 3
 +
    | Hs_GenLoc_start = 38155157
 +
    | Hs_GenLoc_end = 38159514
 +
    | Hs_Uniprot = Q99836
 +
    | Mm_EntrezGene = 17874
 +
    | Mm_Ensembl = ENSMUSG00000032508
 +
    | Mm_RefseqmRNA = NM_010851
 +
    | Mm_RefseqProtein = NP_034981
 +
    | Mm_GenLoc_db = 
 +
    | Mm_GenLoc_chr = 9
 +
    | Mm_GenLoc_start = 119184642
 +
    | Mm_GenLoc_end = 119188700
 +
    | Mm_Uniprot = Q0PM15
 +
  }}
 +
}}
 +
'''Myeloid differentiation primary response gene (88) (MYD88)''' is a universal [[adapter protein]] as it is used by all [[toll-like receptor|TLR]]s (except [[TLR 3]]) to activate [[transcription factor]] [[Nfkappa B]]. Mal is necessary to recruit Myd88 to [[TLR 2]] and [[TLR 4]]. TLRs can use Myd88 dependent and independent pathways. '''MYD88''' is also its human [[gene]].<ref>{{cite web | title = Entrez Gene: MYD88 Myeloid differentiation primary response gene (88)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4615| accessdate = }}</ref>
  
 
[[Image:Toll-like receptor pathways revised.jpg|thumbnail|center|500px|Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations]]
 
[[Image:Toll-like receptor pathways revised.jpg|thumbnail|center|500px|Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations]]
Line 29: Line 57:
  
 
==References==
 
==References==
<references/>
+
{{reflist}}
 +
==Further reading==
 +
{{refbegin | 2}}
 +
{{PBB_Further_reading
 +
| citations =
 +
*{{cite journal  | author=Hardiman G, Rock FL, Balasubramanian S, ''et al.'' |title=Molecular characterization and modular analysis of human MyD88. |journal=Oncogene |volume=13 |issue= 11 |pages= 2467-75 |year= 1997 |pmid= 8957090 |doi=  }}
 +
*{{cite journal  | author=Bonnert TP, Garka KE, Parnet P, ''et al.'' |title=The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. |journal=FEBS Lett. |volume=402 |issue= 1 |pages= 81-4 |year= 1997 |pmid= 9013863 |doi=  }}
 +
*{{cite journal  | author=Hardiman G, Jenkins NA, Copeland NG, ''et al.'' |title=Genetic structure and chromosomal mapping of MyD88. |journal=Genomics |volume=45 |issue= 2 |pages= 332-9 |year= 1998 |pmid= 9344657 |doi= 10.1006/geno.1997.4940 }}
 +
*{{cite journal  | author=Muzio M, Ni J, Feng P, Dixit VM |title=IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. |journal=Science |volume=278 |issue= 5343 |pages= 1612-5 |year= 1997 |pmid= 9374458 |doi=  }}
 +
*{{cite journal  | author=Jaunin F, Burns K, Tschopp J, ''et al.'' |title=Ultrastructural distribution of the death-domain-containing MyD88 protein in HeLa cells. |journal=Exp. Cell Res. |volume=243 |issue= 1 |pages= 67-75 |year= 1998 |pmid= 9716450 |doi= 10.1006/excr.1998.4131 }}
 +
*{{cite journal  | author=Wesche H, Gao X, Li X, ''et al.'' |title=IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19403-10 |year= 1999 |pmid= 10383454 |doi=  }}
 +
*{{cite journal  | author=Burns K, Clatworthy J, Martin L, ''et al.'' |title=Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. |journal=Nat. Cell Biol. |volume=2 |issue= 6 |pages= 346-51 |year= 2000 |pmid= 10854325 |doi= 10.1038/35014038 }}
 +
*{{cite journal  | author=Aliprantis AO, Yang RB, Weiss DS, ''et al.'' |title=The apoptotic signaling pathway activated by Toll-like receptor-2. |journal=EMBO J. |volume=19 |issue= 13 |pages= 3325-36 |year= 2000 |pmid= 10880445 |doi= 10.1093/emboj/19.13.3325 }}
 +
*{{cite journal  | author=Rhee SH, Hwang D |title=Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase. |journal=J. Biol. Chem. |volume=275 |issue= 44 |pages= 34035-40 |year= 2000 |pmid= 10952994 |doi= 10.1074/jbc.M007386200 }}
 +
*{{cite journal  | author=Fitzgerald KA, Palsson-McDermott EM, Bowie AG, ''et al.'' |title=Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. |journal=Nature |volume=413 |issue= 6851 |pages= 78-83 |year= 2001 |pmid= 11544529 |doi= 10.1038/35092578 }}
 +
*{{cite journal  | author=Tauszig-Delamasure S, Bilak H, Capovilla M, ''et al.'' |title=Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections. |journal=Nat. Immunol. |volume=3 |issue= 1 |pages= 91-7 |year= 2002 |pmid= 11743586 |doi= 10.1038/ni747 }}
 +
*{{cite journal  | author=Bannerman DD, Tupper JC, Kelly JD, ''et al.'' |title=The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta. |journal=J. Clin. Invest. |volume=109 |issue= 3 |pages= 419-25 |year= 2002 |pmid= 11828002 |doi=  }}
 +
*{{cite journal  | author=Tamai R, Sakuta T, Matsushita K, ''et al.'' |title=Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression. |journal=Infect. Immun. |volume=70 |issue= 3 |pages= 1272-8 |year= 2002 |pmid= 11854210 |doi=  }}
 +
*{{cite journal  | author=Radons J, Gabler S, Wesche H, ''et al.'' |title=Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16456-63 |year= 2002 |pmid= 11880380 |doi= 10.1074/jbc.M201000200 }}
 +
*{{cite journal  | author=Janssens S, Burns K, Tschopp J, Beyaert R |title=Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88. |journal=Curr. Biol. |volume=12 |issue= 6 |pages= 467-71 |year= 2002 |pmid= 11909531 |doi=  }}
 +
*{{cite journal  | author=Li S, Strelow A, Fontana EJ, Wesche H |title=IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 8 |pages= 5567-72 |year= 2002 |pmid= 11960013 |doi= 10.1073/pnas.082100399 }}
 +
*{{cite journal  | author=Medvedev AE, Lentschat A, Wahl LM, ''et al.'' |title=Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. |journal=J. Immunol. |volume=169 |issue= 9 |pages= 5209-16 |year= 2002 |pmid= 12391239 |doi=  }}
 +
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
 +
*{{cite journal  | author=Raschi E, Testoni C, Bosisio D, ''et al.'' |title=Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. |journal=Blood |volume=101 |issue= 9 |pages= 3495-500 |year= 2003 |pmid= 12531807 |doi= 10.1182/blood-2002-08-2349 }}
 +
*{{cite journal  | author=Doyle SE, O'Connell R, Vaidya SA, ''et al.'' |title=Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4. |journal=J. Immunol. |volume=170 |issue= 7 |pages= 3565-71 |year= 2003 |pmid= 12646618 |doi=  }}
 +
}}
 +
{{refend}}
  
 
==External links==
 
==External links==
Line 35: Line 89:
  
 
{{Adaptor proteins}}
 
{{Adaptor proteins}}
 
+
{{protein-stub}}
 
[[Category:Immune system]]
 
[[Category:Immune system]]

Latest revision as of 00:40, 5 May 2008


Myeloid differentiation primary response gene (88)
Identifiers
Symbols MYD88 ;
External IDs OMIM: 602170 MGI108005 HomoloGene1849
RNA expression pattern
File:PBB GE MYD88 209124 at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 4615
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 17874

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000172936
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000032508

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q99836
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| Q0PM15

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_002468 (mRNA)
NP_002459 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_010851 (mRNA)
NP_034981 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 3: 38.16 - 38.16 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 9: 119.18 -  119.19 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Myeloid differentiation primary response gene (88) (MYD88) is a universal adapter protein as it is used by all TLRs (except TLR 3) to activate transcription factor Nfkappa B. Mal is necessary to recruit Myd88 to TLR 2 and TLR 4. TLRs can use Myd88 dependent and independent pathways. MYD88 is also its human gene.[1]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

History

MyD88 was originally discovered and cloned by Drs Dan A Liebermann& Barbara Hoffman as "Myeloid Differentiation primary response gene 88". [2]

MAL was found by Katherine Fitzgerald et al.[3]

References

  1. "Entrez Gene: MYD88 Myeloid differentiation primary response gene (88)".
  2. Lord KA, Hoffman-Liebermann B, Liebermann DA (1990). "Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6". Oncogene. 5 (7): 1095–7. PMID 2374694.
  3. Fitzgerald KA, Palsson-McDermott EM, Bowie AG; et al. (2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529.

Further reading

  • Hardiman G, Rock FL, Balasubramanian S; et al. (1997). "Molecular characterization and modular analysis of human MyD88". Oncogene. 13 (11): 2467–75. PMID 8957090.
  • Bonnert TP, Garka KE, Parnet P; et al. (1997). "The cloning and characterization of human MyD88: a member of an IL-1 receptor related family". FEBS Lett. 402 (1): 81–4. PMID 9013863.
  • Hardiman G, Jenkins NA, Copeland NG; et al. (1998). "Genetic structure and chromosomal mapping of MyD88". Genomics. 45 (2): 332–9. doi:10.1006/geno.1997.4940. PMID 9344657.
  • Muzio M, Ni J, Feng P, Dixit VM (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. PMID 9374458.
  • Jaunin F, Burns K, Tschopp J; et al. (1998). "Ultrastructural distribution of the death-domain-containing MyD88 protein in HeLa cells". Exp. Cell Res. 243 (1): 67–75. doi:10.1006/excr.1998.4131. PMID 9716450.
  • Wesche H, Gao X, Li X; et al. (1999). "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family". J. Biol. Chem. 274 (27): 19403–10. PMID 10383454.
  • Burns K, Clatworthy J, Martin L; et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID 10854325.
  • Aliprantis AO, Yang RB, Weiss DS; et al. (2000). "The apoptotic signaling pathway activated by Toll-like receptor-2". EMBO J. 19 (13): 3325–36. doi:10.1093/emboj/19.13.3325. PMID 10880445.
  • Rhee SH, Hwang D (2000). "Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase". J. Biol. Chem. 275 (44): 34035–40. doi:10.1074/jbc.M007386200. PMID 10952994.
  • Fitzgerald KA, Palsson-McDermott EM, Bowie AG; et al. (2001). "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction". Nature. 413 (6851): 78–83. doi:10.1038/35092578. PMID 11544529.
  • Tauszig-Delamasure S, Bilak H, Capovilla M; et al. (2002). "Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections". Nat. Immunol. 3 (1): 91–7. doi:10.1038/ni747. PMID 11743586.
  • Bannerman DD, Tupper JC, Kelly JD; et al. (2002). "The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta". J. Clin. Invest. 109 (3): 419–25. PMID 11828002.
  • Tamai R, Sakuta T, Matsushita K; et al. (2002). "Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression". Infect. Immun. 70 (3): 1272–8. PMID 11854210.
  • Radons J, Gabler S, Wesche H; et al. (2002). "Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling". J. Biol. Chem. 277 (19): 16456–63. doi:10.1074/jbc.M201000200. PMID 11880380.
  • Janssens S, Burns K, Tschopp J, Beyaert R (2002). "Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88". Curr. Biol. 12 (6): 467–71. PMID 11909531.
  • Li S, Strelow A, Fontana EJ, Wesche H (2002). "IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5567–72. doi:10.1073/pnas.082100399. PMID 11960013.
  • Medvedev AE, Lentschat A, Wahl LM; et al. (2002). "Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells". J. Immunol. 169 (9): 5209–16. PMID 12391239.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Raschi E, Testoni C, Bosisio D; et al. (2003). "Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies". Blood. 101 (9): 3495–500. doi:10.1182/blood-2002-08-2349. PMID 12531807.
  • Doyle SE, O'Connell R, Vaidya SA; et al. (2003). "Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4". J. Immunol. 170 (7): 3565–71. PMID 12646618.

External links


Linked-in.jpg