Mycosis fungoides laboratory findings
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Cutaneous T cell lymphoma Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Laboratory tests for cutaneous T cell lymphoma include complete blood count (CBC), blood chemistry studies, flow cytometry, immunohistochemistry, and immunophenotyping.
Laboratory Tests
Laboratory tests for cutaneous T cell lymphoma include:[1]
- Complete blood count (CBC)
- Peripheral blood smear
- Atypical T-cells (Sezary cells)
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) demonstrated progressive disease had undergone.
- Blood chemistry studies
- High level lactate dehydrogenase (LDH)in andvanced disease stage patients
- Biopsy of skin ( multiple biopsies)
- A rare evaluated finding observed mono nuclear cells aggrigation by cerebriform nuclei in the epidermis surrounding Langerhans cells.
- Atypical lymphocytes observed in the epidermis or superficial dermis.
- Lymph node biopsies is recommended.
- complete metabolic panel
- Flow cytometry
- Immunohistochemistry
- Immunophenotyping: Beta F1+, CD2-/+, CD3+, CD3- (CD4-positive variant), CD4+ (CD4-positive variant), CD4-, CD5-, CD7+/-, CD8+, CD8- (CD4-positive variant), Granzyme B+, and Perforin+
- Loss of CD26 and CD7 expression
References
- ↑ Vural, Seçil; Akay, Bengü Nisa; Botsali, Ayşenur; Atilla, Erden; Parlak, Nehir; Okcu Heper, Aylin; Şanlı, Hatice (2018). "Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis". Turkish Journal of Hematology. 35 (1): 35–41. doi:10.4274/tjh.2016.0502. ISSN 1300-7777.