Multiple sclerosis differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

  • Overview

Differentiating multiple sclerosis from other diseases

Multiple sclerosis must be differentiated from other diseases that can mimic this disease clinically or radiologically such as:

Inflammatory/autoimmune conditions:

Infections:

Metabolic and Genetic/Heriditary Disorders:

  1. Metachromatic leukodystrophy: MLD is an autosomal recessive lysosomal storage disease that leads to accumulation of galactosyl sulfatide.[34][35]
  2. Fabry’s disease:
  3. Krabbe’s disease:

CNS lymphoma

Primary CNS lymphoma is mostly diffuse large B-cell lymphoma (DLBCL).[38] These patients more commonly present with neurological manifestation rather than B symptoms.

spinal diseases

References

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