Mucormycosis

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Mucormycosis
Mucormycosis.jpg
Periorbital fungal infection known as mucormycosis or phycomycosis
ICD-10 B46.0-B46.5
ICD-9 117.7
DiseasesDB 31759
eMedicine med/1513 
MeSH D009091
Phycomycosis
ICD-10 B46
ICD-9 117.7
DiseasesDB 31329
MeSH D020096
Basidiobolomycosis
ICD-10 B46
ICD-9 117.7
MedlinePlus 000649
eMedicine med/2735  med/1513
MeSH D009091

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Mucormycosis (also known as zygomycosis) is a rare but serious infection of fungi of the Mucorales order.[1] The most common fungi responsible for mucormycosis in humans are Mucor and Rhizopus.

Presentation

It that frequently involves the sinuses, brain, or lungs and most commonly presents in immunocompromised patients.

While orbitorhinocerebral mucormycosis is the most common type of the disease, this infection can also manifest in the gastrointestinal tract, skin, and in other organ systems.

Associated conditions

Some 50-75% of patients diagnosed with mucormycosis are estimated to have underlying poorly controlled diabetes mellitus and ketoacidosis.

Treatment

Surgical resection of the "fungus ball" and intravenous amphotericin B is the recommended therapy.

Case Example: Carotid Artery Mucormycosis

Clinical Summary

A 63-year-old white male was in his usual state of good health until eight weeks before his death when he developed sudden onset of shortness of breath. A thoracotomy was performed for plication of ruptured emphysematous blebs.

Following improvement and discharge from the hospital he developed weakness, lethargy, and a left lower lobe lung infiltrate. The patient's condition soon deteriorated further, with almost every organ system having failed. The patient developed DIC and peripheral embolic phenomena, including gangrene of his extremities and face.

A single antemortem blood culture grew Staphylococcus aureus.

Postmortem Findings

Autopsy revealed severe emphysema, severe widespread abscessiform and necrotizing pneumonia, and bacterial endocarditis (Staphylococcus aureus) of the pulmonic valve. The right internal carotid artery was occluded by a thrombus and there were areas of necrosis (due to CVAs) in the brain.

Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology




References

  1. "eMedicine - Mucormycosis : Article by Nancy F Crum-Cianflone, MD MPH". Retrieved 2007-09-30.

External links

Cost Effectiveness of Mucormycosis

| group5 = Clinical Trials Involving Mucormycosis | list5 = Ongoing Trials on Mucormycosis at Clinical Trials.govTrial results on MucormycosisClinical Trials on Mucormycosis at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Mucormycosis | list6 = US National Guidelines Clearinghouse on MucormycosisNICE Guidance on MucormycosisNHS PRODIGY GuidanceFDA on MucormycosisCDC on Mucormycosis


| group7 = Textbook Information on Mucormycosis | list7 = Books and Textbook Information on Mucormycosis


| group8 = Pharmacology Resources on Mucormycosis | list8 = AND (Dose)}} Dosing of MucormycosisAND (drug interactions)}} Drug interactions with MucormycosisAND (side effects)}} Side effects of MucormycosisAND (Allergy)}} Allergic reactions to MucormycosisAND (overdose)}} Overdose information on MucormycosisAND (carcinogenicity)}} Carcinogenicity information on MucormycosisAND (pregnancy)}} Mucormycosis in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Mucormycosis


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Mucormycosis | list9 = AND (pharmacogenomics)}} Genetics of MucormycosisAND (pharmacogenomics)}} Pharmacogenomics of MucormycosisAND (proteomics)}} Proteomics of Mucormycosis


| group10 = Newstories on Mucormycosis | list10 = Mucormycosis in the newsBe alerted to news on MucormycosisNews trends on Mucormycosis


| group11 = Commentary on Mucormycosis | list11 = Blogs on Mucormycosis

| group12 = Patient Resources on Mucormycosis | list12 = Patient resources on MucormycosisDiscussion groups on MucormycosisPatient Handouts on MucormycosisDirections to Hospitals Treating MucormycosisRisk calculators and risk factors for Mucormycosis


| group13 = Healthcare Provider Resources on Mucormycosis | list13 = Symptoms of MucormycosisCauses & Risk Factors for MucormycosisDiagnostic studies for MucormycosisTreatment of Mucormycosis

| group14 = Continuing Medical Education (CME) Programs on Mucormycosis | list14 = CME Programs on Mucormycosis

| group15 = International Resources on Mucormycosis | list15 = Mucormycosis en EspanolMucormycosis en Francais

| group16 = Business Resources on Mucormycosis | list16 = Mucormycosis in the MarketplacePatents on Mucormycosis

| group17 = Informatics Resources on Mucormycosis | list17 = List of terms related to Mucormycosis


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