Monoamine oxidase B

Monoamine oxidase B
PDB rendering based on 1gos.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1gos​, 1oj9​, 1oja​, 1ojb​, 1ojc​, 1ojd​, 1s2q​, 1s2y​, 1s3b​, 1s3e​, 2bk3​, 2bk4​, 2bk5​, 2byb​, 2c64​, 2c65​, 2c66​, 2c67​, 2c70​, 2c72​, 2c73​, 2c75​, 2c76​
Identifiers
Symbols	MAOB ; MGC26382
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20251
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Monoamine oxidase B, also known as MAOB, is a human gene.

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is an enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine.

Further reading

• Edmondson DE, Binda C, Mattevi A (2004). "The FAD binding sites of human monoamine oxidases A and B.". Neurotoxicology. 25 (1–2): 63–72. doi:10.1016/S0161-813X(03)00114-1. PMID 14697881.CS1 maint: Multiple names: authors list (link)
• Kumar MJ, Andersen JK (2004). "Perspectives on MAO-B in aging and neurological disease: where do we go from here?". Mol. Neurobiol. 30 (1): 77–89. PMID 15247489.
• Ghozlan A, Munnich A (2004). "[MAOB: a modifier gene in phenylketonuria?]". Med Sci (Paris). 20 (10): 929–32. PMID 15461973.
• Zhu QS, Grimsby J, Chen K, Shih JC (1992). "Promoter organization and activity of human monoamine oxidase (MAO) A and B genes". J. Neurosci. 12 (11): 4437–46. PMID 1432104.CS1 maint: Multiple names: authors list (link)
• Grimsby J, Chen K, Wang LJ; et al. (1991). "Human monoamine oxidase A and B genes exhibit identical exon-intron organization". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3637–41. PMID 2023912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bach AW, Lan NC, Johnson DL; et al. (1988). "cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties". Proc. Natl. Acad. Sci. U.S.A. 85 (13): 4934–8. PMID 3387449.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kochersperger LM, Parker EL, Siciliano M; et al. (1987). "Assignment of genes for human monoamine oxidases A and B to the X chromosome". J. Neurosci. Res. 16 (4): 601–16. doi:10.1002/jnr.490160403. PMID 3540317.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wyatt RJ, Murphy DL, Belmaker R; et al. (1973). "Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia". Science. 179 (76): 916–8. PMID 4687789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goldin LR, Gershon ES, Lake CR; et al. (1982). "Segregation and linkage studies of plasma dopamine-beta-hydroxylase (DBH), erythrocyte catechol-O-methyltransferase (COMT), and platelet monoamine oxidase (MAO): possible linkage between the ABO locus and a gene controlling DBH activity". Am. J. Hum. Genet. 34 (2): 250–62. PMID 6951409.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Denney RM, Fritz RR, Patel NT, Abell CW (1982). "Human liver MAO-A and MAO-B separated by immunoaffinity chromatography with MAO-B-specific monoclonal antibody". Science. 215 (4538): 1400–3. PMID 7063850.CS1 maint: Multiple names: authors list (link)
• Raddatz R, Parini A, Lanier SM (1996). "Imidazoline/guanidinium binding domains on monoamine oxidases. Relationship to subtypes of imidazoline-binding proteins and tissue-specific interaction of imidazoline ligands with monoamine oxidase B.". J. Biol. Chem. 270 (46): 27961–8. PMID 7499273.CS1 maint: Multiple names: authors list (link)
• Woo JC, Silverman RB (1994). "Observation of two different chromophores in the resting state of monoamine oxidase B by fluorescence spectroscopy". Biochem. Biophys. Res. Commun. 202 (3): 1574–8. doi:10.1006/bbrc.1994.2111. PMID 8060341.
• Wu HF, Chen K, Shih JC (1993). "Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines". Mol. Pharmacol. 43 (6): 888–93. PMID 8316221.CS1 maint: Multiple names: authors list (link)
• Chen K, Wu HF, Shih JC (1993). "The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical". J. Neurochem. 61 (1): 187–90. PMID 8515265.CS1 maint: Multiple names: authors list (link)
• Fowler JS, Volkow ND, Wang GJ; et al. (1996). "Inhibition of monoamine oxidase B in the brains of smokers". Nature. 379 (6567): 733–6. doi:10.1038/379733a0. PMID 8602220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lenders JW, Eisenhofer G, Abeling NG; et al. (1996). "Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinical phenotypes". J. Clin. Invest. 97 (4): 1010–9. PMID 8613523.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cesura AM, Gottowik J, Lahm HW; et al. (1996). "Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis". Eur. J. Biochem. 236 (3): 996–1002. PMID 8665924.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Saura J, Bleuel Z, Ulrich J; et al. (1997). "Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry". Neuroscience. 70 (3): 755–74. PMID 9045087.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Checkoway H, Franklin GM, Costa-Mallen P; et al. (1998). "A genetic polymorphism of MAO-B modifies the association of cigarette smoking and Parkinson's disease". Neurology. 50 (5): 1458–61. PMID 9596006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

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