Microangiopathic hemolytic anemia history and symptoms: Difference between revisions
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{{Microangiopathic hemolytic anemia}} | {{Microangiopathic hemolytic anemia}} {{MSJ}} | ||
==Overview== | |||
The [[patient]]s have a wide spectrum of clinical picture ranging from asymptomatic to [[anemia]], [[thrombocytopenia]], [[fever]], [[altered mental status]] and impaired [[renal]] function<ref name="pmid25119611">{{cite journal| author=George JN, Nester CM| title=Syndromes of thrombotic microangiopathy. | journal=N Engl J Med | year= 2014 | volume= 371 | issue= 7 | pages= 654-66 | pmid=25119611 | doi=10.1056/NEJMra1312353 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25119611 }} </ref>. Some [[patient]]s may also present with [[abdominal]] or [[cardiac]] symptoms<ref name="pmid28447417">{{cite journal| author=Kottke-Marchant K| title=Diagnostic approach to microangiopathic hemolytic disorders. | journal=Int J Lab Hematol | year= 2017 | volume= 39 Suppl 1 | issue= | pages= 69-75 | pmid=28447417 | doi=10.1111/ijlh.12671 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28447417 }} </ref>. | |||
==History and Symptoms== | |||
===Common Symptoms=== | |||
Common symptoms of [[microangiopathic hemolytic anemia]] include<ref name="pmid28447417">{{cite journal| author=Kottke-Marchant K| title=Diagnostic approach to microangiopathic hemolytic disorders. | journal=Int J Lab Hematol | year= 2017 | volume= 39 Suppl 1 | issue= | pages= 69-75 | pmid=28447417 | doi=10.1111/ijlh.12671 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28447417 }} </ref><ref name="pmid32595044">{{cite journal| author=| title=Correction to Lancet Infectious Diseases 2020; published online April 29. https://doi.org/10.1016/ S1473-3099(20)30064-5. | journal=Lancet Infect Dis | year= 2020 | volume= 20 | issue= 7 | pages= e148 | pmid=32595044 | doi=10.1016/S1473-3099(20)30370-4 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32595044 }} </ref>: | |||
* [[Pallor]] | |||
* Yellowing of [[sclera]] and [[skin]] | |||
* Dark colored urine due to raised level of [[urobilinogen]] and unconjugated [[bilirubin]] | |||
* [[Breathlessness]] | |||
* Easy [[fatigability]] | |||
* [[Petechia]] | |||
* [[Purpura]] | |||
* [[Epistaxis]] | |||
* [[Bleeding]] from [[mucous membrane]]s | |||
* [[Fever]] | |||
* [[Altered mental status]] | |||
* [[Seizures]] | |||
* [[Stroke]] | |||
* [[Dizziness]] | |||
* [[Slurred speech]] | |||
* [[Transient ischemic attacks]] | |||
* [[Renal failure]] | |||
* [[Oliguria]] | |||
===Less Common Symptoms=== | |||
Less common symptoms of [[microangiopathic hemolytic anemia]] include: | |||
* [[Abdominal pain]] | |||
* [[Nausea]] | |||
* [[Vomitting]] | |||
* [[Hematuria]] | |||
* [[Hypertension]] | |||
* [[Generalized Edema]] | |||
* [[Cardiac]] [[arrhythmia]] | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 18:40, 21 January 2021
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Overview
The patients have a wide spectrum of clinical picture ranging from asymptomatic to anemia, thrombocytopenia, fever, altered mental status and impaired renal function[1]. Some patients may also present with abdominal or cardiac symptoms[2].
History and Symptoms
Common Symptoms
Common symptoms of microangiopathic hemolytic anemia include[2][3]:
- Pallor
- Yellowing of sclera and skin
- Dark colored urine due to raised level of urobilinogen and unconjugated bilirubin
- Breathlessness
- Easy fatigability
- Petechia
- Purpura
- Epistaxis
- Bleeding from mucous membranes
- Fever
- Altered mental status
- Seizures
- Stroke
- Dizziness
- Slurred speech
- Transient ischemic attacks
- Renal failure
- Oliguria
Less Common Symptoms
Less common symptoms of microangiopathic hemolytic anemia include:
References
- ↑ George JN, Nester CM (2014). "Syndromes of thrombotic microangiopathy". N Engl J Med. 371 (7): 654–66. doi:10.1056/NEJMra1312353. PMID 25119611.
- ↑ 2.0 2.1 Kottke-Marchant K (2017). "Diagnostic approach to microangiopathic hemolytic disorders". Int J Lab Hematol. 39 Suppl 1: 69–75. doi:10.1111/ijlh.12671. PMID 28447417.
- ↑ "Correction to Lancet Infectious Diseases 2020; published online April 29. https://doi.org/10.1016/ S1473-3099(20)30064-5". Lancet Infect Dis. 20 (7): e148. 2020. doi:10.1016/S1473-3099(20)30370-4. PMID 32595044 Check
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