Methylphenidate (oral)
Synonyms / Brand Names: Methyl phenidyl acetate, Methylphenidate HCl, Methylphenidate hydrochloride, Methylphenidatum, Methylphenidylacetate hydrochloride, Metilfenidat hydrochloride, Metilfenidato, Metilfenidato, Phenidylate, d-methylphenidate HCl, 4311/B Ciba, Calocain, Centedein, Centedrin, Centedrine, Centredin, Concerta, Focalin, Focalin XR, Methylphen, Meridil, Metadate, Metadate CD, Metadate ER, Methylin, Methylin ER, Methylofenidan, Methylphenidan, Methypatch, Plimasine, PMS-Methylphenidate, Riphenidate, Ritalin, Ritalin hydrochloride, Ritalin LA, Ritalin SR, Ritalin-SR, Ritaline, Ritcher Works, Daytrana
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Dosing and Administration
Dosage should be individualized according to the needs and responses of the patient.
Adults
- Tablets: Administer in divided doses 2 or 3 times daily, preferably 30 to 45 minutes before meals. Average dosage is 20 to 30 mg daily. Some patients may require 40 to 60 mg daily. In others, 10 to 15 mg daily will be adequate. Patients who are unable to sleep if medication is taken late in the day should take the last dose before 6 p.m.
- Extended-release tablets: Methylphenidate hydrochloride extended-release tablets have a duration of action of approximately 8 hours. Therefore, the extended-release tablets may be used in place of the immediate-release tablets when the 8-hour dosage of Methylphenidate hydrochloride extended-release tablets corresponds to the titrated 8-hour dosage of the immediate-release tablets. Methylphenidate hydrochloride extended-release tablets must be swallowed whole and never crushed or chewed.
See Instructions for Administration for further instructions.
FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.
Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.
Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Trial Resources
Ongoing Trials, Trial Results
Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
FDA Package Insert Resources
Indications
Contraindications
Side Effects
Drug Interactions
Precautions
Overdose
Instructions for Administration
How Supplied
Pharmacokinetics and Molecular Data
FDA label
FDA on Methylphenidate (oral)
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Publication Resources
Most Recent Articles on Methylphenidate (oral)
Review Articles on Methylphenidate (oral)
Articles on Methylphenidate (oral) in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Methylphenidate (oral)
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Trial Resources
Ongoing Trials with Methylphenidate (oral) at Clinical Trials.gov
Trial Results with Methylphenidate (oral)
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Methylphenidate (oral)
Cochrane Collaboration on Methylphenidate (oral)
Cost Effectiveness of Methylphenidate (oral)
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Media Resources
Powerpoint Slides on Methylphenidate (oral)
Images of Methylphenidate (oral)
Podcasts & MP3s on Methylphenidate (oral)
Videos on Methylphenidate (oral)
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Patient Resources
Patient Information from National Library of Medicine
Patient Resources on Methylphenidate (oral)
Discussion Groups on Methylphenidate (oral)
Patient Handouts on Methylphenidate (oral)
Blogs on Methylphenidate (oral)
Methylphenidate (oral) in the News
Methylphenidate (oral) in the Marketplace
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International Resources
Methylphenidate (oral) en Español
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Adapted from the FDA Package Insert.