Menadione

Menadione
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gloria Picoy [2]

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NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Overview

Menadione is a polycyclic aromatic ketone that is FDA approved for the treatment of joint pains, bruising, fatigue, abdominal discomfort, diarrhea, and hay fever.. Common adverse reactions include {{{adverseReactions}}}.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

• For temporary relief of joint pains, bruising, fatigue, abdominal discomfort, diarrhea, and hay fever.

• Dosage: 1-10 drops under the tongue, 3 times a day

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Menadione in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Menadione in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Consult a physician for use in children under 12 years of age.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Menadione in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Menadione in pediatric patients.

Contraindications

There is limited information regarding Menadione Contraindications in the drug label.

Warnings

• If pregnant or breast-feeding, ask a health care professional before use.
• Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
• Do not use if tamper evident seal is broken or missing. Store in a cool, dry place.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Menadione Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Menadione Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Menadione Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Menadione in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Menadione in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Menadione during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Menadione in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Menadione in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Menadione in geriatric settings.

Gender

There is no FDA guidance on the use of Menadione with respect to specific gender populations.

Race

There is no FDA guidance on the use of Menadione with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Menadione in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Menadione in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Menadione in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Menadione in patients who are immunocompromised.

Administration and Monitoring

Administration

Oral

Monitoring

There is limited information regarding Menadione Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Menadione and IV administrations.

Overdosage

There is limited information regarding Menadione overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

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Template:Chembox header2 | Menadione
Identifiers
CAS Number	58-27-5 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:28869 N
ChEMBL	ChEMBL590 Y
ChemSpider	3915 Y
DrugBank	DB00170 N
ECHA InfoCard
KEGG	D02335 Y
PubChem CID	4055
UNII	723JX6CXY5 Y
InChI InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3 Y Key: MJVAVZPDRWSRRC-UHFFFAOYSA-N Y InChI=1/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3 Key: MJVAVZPDRWSRRC-UHFFFAOYAY
SMILES O=C\2c1c(cccc1)C(=O)/C(=C/2)C
Properties
Chemical formula	C11H8O2
Molar mass	172.18 g·mol−1
Hazards
Template:Chembox header2 | Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references

Mechanism of Action

There is limited information regarding Menadione Mechanism of Action in the drug label.

Structure

There is limited information regarding Menadione Structure in the drug label.

Pharmacodynamics

There is limited information regarding Menadione Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Menadione Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Menadione Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Menadione Clinical Studies in the drug label.

How Supplied

Menadione 1 FL OZ (30 ml)

Storage

There is limited information regarding Menadione Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Menadione Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Menadione interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

• Menadione

Look-Alike Drug Names

There is limited information regarding Menadione Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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