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| {{Drugbox|
| | #REDIRECT [[Melphalan (patient information)]] |
| |IUPAC_name = 2-amino-3-[4-[bis(2-chloroethyl)amino]phenyl]-<br>propanoic acid
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| | image=Melphalan.svg
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| | CAS_number=148-82-3
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| | ATC_prefix=L01
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| | ATC_suffix=AA03
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| | PubChem=4053
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| | DrugBank=APRD00118
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| | C = 13 | H = 18 | Cl = 2 | N = 2 | O = 2
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| | molecular_weight = 305.2 g/mol
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| | bioavailability= 25% to 89%
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| | metabolism = hydrolysis
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| | elimination_half-life=1.5 ± 0.8 hours
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| | excretion = [[Kidney|Renal]], significantly metabolised
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| | pregnancy_AU =
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| | pregnancy_US =
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| | pregnancy_category =
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| | legal_status = Rx-only
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| | routes_of_administration= Oral, [[Intravenous therapy|intravenous]]
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| }}
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| '''Melphalan hydrochloride''' (trade name '''Alkeran''') is a [[chemotherapy]] [[medication|drug]] belonging to the class of [[nitrogen mustard]] [[alkylating antineoplastic agent|alkylating agent]]s. It is used primarily to treat [[multiple myeloma]] and [[ovarian cancer]], and occasionally [[malignant melanoma]]. Otherwise known as L-Phenylalanine Mustard, or L-PAM, melphalan is a [[phenylalanine]] derivative of [[mechlorethamine]]. The agent was first investigated as a possible drug for use in melanoma. It did not work, but was found to be of use in myeloma.
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| ==Administration==
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| Oral or intravenous; dosing varies by purpose and route of administration as well as patient weight.
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| ==Side effects==
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| Common side effects include:
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| *[[Nausea]] and vomiting
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| *[[Bone marrow]] suppression, including
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| **[[leukopenia|Decreased white blood cell count]] causing increased risk of [[infection]]
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| **[[thrombocytopenia|Decreased platelet count]] causing increased risk of bleeding
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| Less common side effects include:
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| *Severe allergic reactions
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| *Scarring of lung tissue (usually only with prolonged use)
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| *[[alopecia|Hair loss]]
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| *[[Rash]]
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| *[[pruritus|Itching]]
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| [[Category: chemotherapeutic agents]]
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| {{pharma-stub}}
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| {{Chemotherapeutic agents}}
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| [[ja:メルファラン]]
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| [[pl:Melfalan]]
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