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==Overview==
==Overview==
Medullary thyroid cancer was first discovered by John Beach Hazard, an American pathologist, in 1959.<ref name="pmid13620740">{{cite journal |vauthors=HAZARD JB, HAWK WA, CRILE G |title=Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity |journal=J. Clin. Endocrinol. Metab. |volume=19 |issue=1 |pages=152–61 |year=1959 |pmid=13620740 |doi=10.1210/jcem-19-1-152 |url=}}</ref>
Medullary thyroid cancer was first discovered by Dr. John Beach Hazard, an American [[pathologist]], in 1959.
==Historical Perspective==
==Historical Perspective==
* In 1959 Hazard et al. described medullary (solid) thyroid carcinoma.<ref name="pmid17555398">{{cite journal  |vauthors=Dionigi G, Bianchi V, Rovera F, etal |title=Medullary thyroid carcinoma: surgical treatment advances |journal=Expert Rev Anticancer Ther |volume=7 |issue=6 |pages=877–85 |year=2007 |pmid=17555398 |doi=10.1586/14737140.7.6.877}}</ref>
* In 1959, Dr. Hazard described medullary (solid) thyroid carcinoma.<ref name="pmid13620740">{{cite journal |vauthors=HAZARD JB, HAWK WA, CRILE G |title=Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity |journal=J. Clin. Endocrinol. Metab. |volume=19 |issue=1 |pages=152–61 |year=1959 |pmid=13620740 |doi=10.1210/jcem-19-1-152 |url=}}</ref><ref name="pmid17555398">{{cite journal  |vauthors=Dionigi G, Bianchi V, Rovera F, etal |title=Medullary thyroid carcinoma: surgical treatment advances |journal=Expert Rev Anticancer Ther |volume=7 |issue=6 |pages=877–85 |year=2007 |pmid=17555398 |doi=10.1586/14737140.7.6.877}}</ref>
* In 1961 Sipple described a combination of a [[pheochromocytoma]], medullary thyroid carcinoma and [[parathyroid adenoma]].
* In 1961, Dr. Sipple described a combination of a [[pheochromocytoma]], medullary thyroid carcinoma, and [[parathyroid adenoma]].
* In 1966 Williams ''et al.'' described the combination of mucosal neuromas, [[pheochromocytoma]] and medullary thyroid carcinoma.
* In 1966, Dr. Williams proposed the [[Parafollicular cells|C-cells]] as the origin of medullary thyroid cancer.<ref name="Williams1966">{{cite journal|last1=Williams|first1=E. D.|title=Histogenesis of medullary carcinoma of the thyroid|journal=Journal of Clinical Pathology|volume=19|issue=2|year=1966|pages=114–118|issn=0021-9746|doi=10.1136/jcp.19.2.114}}</ref>
* In 1978, Cameron suggested that medullary thyroid cancer produces thyrocalcitonin from [[parafollicular cell]]s.
* In 1966, Dr. Pearse proposed the name [[Parafollicular cell|C-cell]] indicating their function in calcitonin secrestion.<ref>{{cite journal|title=The cytochemistry of the thyroid C cells and their relationship to calcitonin|journal=Proceedings of the Royal Society of London. Series B. Biological Sciences|volume=164|issue=996|year=1966|pages=478–487|issn=2053-9193|doi=10.1098/rspb.1966.0044}}</ref>
==Discovery==
* In 1978, Dr. Cameron suggested that medullary thyroid cancer produces [[Calcitonin|thyrocalcitonin]] from [[parafollicular cell]]s.
Medullary thyroid cancer was first discovered by John Beach Hazard, an American pathologist, in 1959 following a specimen he observed which had solid non-follicular structure with [[amyloid]] in the stroma.<ref name="pmid13620740">{{cite journal |vauthors=HAZARD JB, HAWK WA, CRILE G |title=Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity |journal=J. Clin. Endocrinol. Metab. |volume=19 |issue=1 |pages=152–61 |year=1959 |pmid=13620740 |doi=10.1210/jcem-19-1-152 |url=}}</ref>
 
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 17:27, 29 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Medullary thyroid cancer was first discovered by Dr. John Beach Hazard, an American pathologist, in 1959.

Historical Perspective

  • In 1959, Dr. Hazard described medullary (solid) thyroid carcinoma.[1][2]
  • In 1961, Dr. Sipple described a combination of a pheochromocytoma, medullary thyroid carcinoma, and parathyroid adenoma.
  • In 1966, Dr. Williams proposed the C-cells as the origin of medullary thyroid cancer.[3]
  • In 1966, Dr. Pearse proposed the name C-cell indicating their function in calcitonin secrestion.[4]
  • In 1978, Dr. Cameron suggested that medullary thyroid cancer produces thyrocalcitonin from parafollicular cells.

References

  1. HAZARD JB, HAWK WA, CRILE G (1959). "Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity". J. Clin. Endocrinol. Metab. 19 (1): 152–61. doi:10.1210/jcem-19-1-152. PMID 13620740.
  2. Dionigi G, Bianchi V, Rovera F, et al. (2007). "Medullary thyroid carcinoma: surgical treatment advances". Expert Rev Anticancer Ther. 7 (6): 877–85. doi:10.1586/14737140.7.6.877. PMID 17555398.
  3. Williams, E. D. (1966). "Histogenesis of medullary carcinoma of the thyroid". Journal of Clinical Pathology. 19 (2): 114–118. doi:10.1136/jcp.19.2.114. ISSN 0021-9746.
  4. "The cytochemistry of the thyroid C cells and their relationship to calcitonin". Proceedings of the Royal Society of London. Series B. Biological Sciences. 164 (996): 478–487. 1966. doi:10.1098/rspb.1966.0044. ISSN 2053-9193.


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