Marburg hemorrhagic fever history and symptoms: Difference between revisions

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Revision as of 16:26, 20 October 2017

Marburg hemorrhagic fever Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief:

Overview

History and Symptoms

Because many of the signs and symptoms of Marburg hemorrhagic fever are similar to those of other infectious diseases, such as malaria or typhoid, diagnosis of the disease can be difficult, especially if only a single case is involved. The incubation period (interval from infection to onset of symptoms) varies from 5 to 10 days. The disease is spread through bodily fluids, including blood, excrement, saliva, and vomit and a history of such contact should be solicited. Many patients develop severe hemorrhagic manifestations between 5 and 7 days, and fatal cases usually have some form of bleeding, often from multiple areas. Fresh blood in vomitus and feces is often accompanied by bleeding from the nose, gums, and vagina. Spontaneous bleeding at venipuncture sites can also occur. The time course varies but the disease lasts betweeen one and three weeks. The fatality rate ranges from 23 to 90%. Death occurs most often between 8 and 9 days after symptom onset, usually preceded by severe blood loss and shock. If a patient survives, recovery is usually prompt and complete, though it may be prolonged in some cases. Persistent symptoms may include inflammation or secondary infection of various organs, including: orchitis, hepatitis, transverse myelitis, uveitis, or parotitis. Involvement of the central nervous system can result in confusion, irritability, and aggression. Orchitis has been reported occasionally in the late phase of disease (15 days).


Marburg Hemorrhagic Fever: Symptoms and Disease Progression
Generalisation Phase (Day 1 to Day 5)
  • Fever
  • Headache
  • Chills
  • Myalgia
  • Malaise
  • Fatigue
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal Pain
  • Conjunctivitis
  • Rash
  • Pharyngitis
Early Organ Phase (Day 6 to Day 13)
  • Fever
  • Bloody Diarrhoea(Malena)
  • Hematemesis
  • Exanthema
  • Petechiae/Ecchymoses
  • Muscosal hemorrhage
  • Visceral hemorrhage
  • Dyspnea
  • Conjunctival injection
  • Edema
  • Apathy/Depression
  • Irritability/Aggression
Late Organ or Convalescence Phase (Day 14 to Day 21)
  • Fever
  • Obtundation
  • Dementia
  • Coma
  • Convulsions
  • Diffuse coagulopathy
  • Metabolic disturbances
  • Shock
  • Myalgia
  • Arthralgia
  • Hepatitis
  • Asthenia
  • Ocular disease
  • Psychosis
  • Social separation
  • Orchitis (inflammation of one or both testicles)

References