Mantle cell lymphoma causes: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 9: | Line 9: | ||
* [[Mantle cell lymphoma]] is usually caused when the somatic cells acquire non-inherited [[genetic mutations]]. | * [[Mantle cell lymphoma]] is usually caused when the somatic cells acquire non-inherited [[genetic mutations]]. | ||
* The typical [[mutation]] occurring in [[mantle cell lymphoma]] due to the “[[reciprocal translocation]]” between [[chromosome 11]] and [[chromosome 14]] t(11;14) causes the over expression of [[cyclin D1]] which results in uncontrolled growth of [[B cells]] leading to [[lymphoma]] development. | * The typical [[mutation]] occurring in [[mantle cell lymphoma]] due to the “[[reciprocal translocation]]” between [[chromosome 11]] and [[chromosome 14]] t(11;14) causes the over expression of [[cyclin D1]] which results in uncontrolled growth of [[B cells]] leading to [[lymphoma]] development. | ||
However, factors | However, the inititating factors of these [[genetic]] alterations are generally not identifiable. People with no particular risk factors for [[lymphoma]] development are commonly affected by these alterations | ||
==References== | ==References== | ||
Revision as of 18:03, 14 November 2018
|
Mantle cell lymphoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Mantle cell lymphoma causes On the Web |
|
American Roentgen Ray Society Images of Mantle cell lymphoma causes |
|
Risk calculators and risk factors for Mantle cell lymphoma causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
The causes of mantle cell lymphoma have not been clearly identified.
Causes
- Mantle cell lymphoma is usually caused when the somatic cells acquire non-inherited genetic mutations.
- The typical mutation occurring in mantle cell lymphoma due to the “reciprocal translocation” between chromosome 11 and chromosome 14 t(11;14) causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development.
However, the inititating factors of these genetic alterations are generally not identifiable. People with no particular risk factors for lymphoma development are commonly affected by these alterations