Mantle cell lymphoma causes: Difference between revisions
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The causes of mantle cell lymphoma have not been clearly identified. | The causes of mantle cell lymphoma have not been clearly identified. | ||
==Causes== | ==Causes== | ||
* Mantle cell lymphoma | * Mantle cell lymphoma results from the acquisition of non-inherited genetic mutations in [[somatic cells]]. | ||
* The typical mutation occurring in mantle cell lymphoma due to the “reciprocal translocation” between chromosome 11 and 14 t(11;14) causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development. | * The typical mutation occurring in mantle cell lymphoma due to the “reciprocal translocation” between chromosome 11 and 14 t(11;14) causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development. | ||
* Recently, weak associations have been observed in the development of mantle cell lymphoma with the following: | * Recently, weak associations have been observed in the development of mantle cell lymphoma with the following: | ||
Revision as of 22:07, 8 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
The causes of mantle cell lymphoma have not been clearly identified.
Causes
- Mantle cell lymphoma results from the acquisition of non-inherited genetic mutations in somatic cells.
- The typical mutation occurring in mantle cell lymphoma due to the “reciprocal translocation” between chromosome 11 and 14 t(11;14) causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development.
- Recently, weak associations have been observed in the development of mantle cell lymphoma with the following:
- With exposure to European strains of Borellia burgdoferi.[1]
- Family history of hematologic malignancy.[2]
- Genetic polymorphisms in the pro-inflammatory cytokine IL-10.[3]
However, factors that initiate the genetic alterations are typically not identifiable, and usually occur in people with no particular risk factors for lymphoma development.
References
- ↑ Schöllkopf C, Melbye M, Munksgaard L, Smedby KE, Rostgaard K, Glimelius B; et al. (2008). "Borrelia infection and risk of non-Hodgkin lymphoma". Blood. 111 (12): 5524–9. doi:10.1182/blood-2007-08-109611. PMC 2972577. PMID 18424667.
- ↑ Wang SS, Slager SL, Brennan P, Holly EA, De Sanjose S, Bernstein L; et al. (2007). "Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)". Blood. 109 (8): 3479–88. doi:10.1182/blood-2006-06-031948. PMC 1852242. PMID 17185468.
- ↑ Skibola CF, Bracci PM, Nieters A, Brooks-Wilson A, de Sanjosé S, Hughes AM; et al. (2010). "Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph Consortium". Am J Epidemiol. 171 (3): 267–76. doi:10.1093/aje/kwp383. PMC 2842204. PMID 20047977.