Major vault protein
| Major vault protein | |||||||||||||
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File:PBB Protein MVP image.jpg PDB rendering based on 1y7x. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MVP ; LRP; VAULT1 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3752 | ||||||||||||
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| RNA expression pattern | |||||||||||||
| File:PBB GE MVP 202180 s at tn.png | |||||||||||||
| File:PBB GE MVP gnf1h10986 at tn.png | |||||||||||||
| File:PBB GE MVP gnf1h10989 at tn.png | |||||||||||||
| More reference expression data | |||||||||||||
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| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
| Location (UCSC) | n/a | n/a | |||||||||||
| PubMed search | n/a | n/a | |||||||||||
Major vault protein, also known as MVP, is a human gene.[1]
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.[1]
References
Further reading
- Izquierdo MA, Scheffer GL, Flens MJ; et al. (1996). "Major vault protein LRP-related multidrug resistance". Eur. J. Cancer. 32A (6): 979–84. PMID 8763338.
- Scheffer GL, Wijngaard PL, Flens MJ; et al. (1995). "The drug resistance-related protein LRP is the human major vault protein". Nat. Med. 1 (6): 578–82. PMID 7585126.
- Slovak ML, Ho JP, Cole SP; et al. (1995). "The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification". Cancer Res. 55 (19): 4214–9. PMID 7671223.
- Izquierdo MA, Scheffer GL, Flens MJ; et al. (1997). "Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors". Am. J. Pathol. 148 (3): 877–87. PMID 8774142.
- Dingemans AM, van Ark-Otte J, van der Valk P; et al. (1997). "Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissues". Ann. Oncol. 7 (6): 625–30. PMID 8879378.
- Sugawara I, Akiyama S, Scheper RJ, Itoyama S (1997). "Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP". Cancer Lett. 112 (1): 23–31. doi:10.1016/S0304-3835(96)04542-9. PMID 9029166.
- Abbondanza C, Rossi V, Roscigno A; et al. (1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". J. Cell Biol. 141 (6): 1301–10. PMID 9628887.
- Ikeda K, Oka M, Yamada Y; et al. (1999). "Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes". Int. J. Cancer. 82 (4): 599–604. PMID 10404077.
- Rimsza LM, Campbell K, Dalton WS; et al. (1999). "The major vault protein (MVP), a new multidrug resistance associated protein, is frequently expressed in multiple myeloma". Leuk. Lymphoma. 34 (3–4): 315–24. PMID 10439368.
- Kickhoefer VA, Siva AC, Kedersha NL; et al. (1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". J. Cell Biol. 146 (5): 917–28. PMID 10477748.
- Kickhoefer VA, Stephen AG, Harrington L; et al. (2000). "Vaults and telomerase share a common subunit, TEP1". J. Biol. Chem. 274 (46): 32712–7. PMID 10551828.
- Lange C, Walther W, Schwabe H, Stein U (2001). "Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter". Biochem. Biophys. Res. Commun. 278 (1): 125–33. doi:10.1006/bbrc.2000.3782. PMID 11071864.
- Holzmann K, Ambrosch I, Elbling L; et al. (2001). "A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant". FEBS Lett. 494 (1–2): 99–104. PMID 11297743.
- van Zon A, Mossink MH, Schoester M; et al. (2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. PMID 11855821.
- Sakaki Y, Terashi K, Yamaguchi A; et al. (2002). "Human T-cell lymphotropic virus type I Tax activates lung resistance-related protein expression in leukemic clones established from an adult T-cell leukemia patient". Exp. Hematol. 30 (4): 340–5. PMID 11937269.
- Zhao Y, Yu L, Wang Q; et al. (2002). "[The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia]". Zhonghua Nei Ke Za Zhi. 41 (3): 183–5. PMID 11940320.
- Scheffer GL, Pijnenborg AC, Smit EF; et al. (2002). "Multidrug resistance related molecules in human and murine lung". J. Clin. Pathol. 55 (5): 332–9. PMID 11986335.
- van den Heuvel-Eibrink MM, Wiemer EA, Prins A; et al. (2002). "Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)". Leukemia. 16 (5): 833–9. doi:10.1038/sj.leu.2402496. PMID 11986944.
- Yu Z, Fotouhi-Ardakani N, Wu L; et al. (2002). "PTEN associates with the vault particles in HeLa cells". J. Biol. Chem. 277 (43): 40247–52. doi:10.1074/jbc.M207608200. PMID 12177006.
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