MYT1
| Myelin transcription factor 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | MYT1 ; MTF1; C20orf36; MYTI; PLPB1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3332 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE MYT1 210341 at tn.png | |||||||||||
| File:PBB GE MYT1 215822 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Myelin transcription factor 1, also known as MYT1, is a human gene.[1]
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.[1]
References
Further reading
- Kim JG, Hudson LD (1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Mol. Cell. Biol. 12 (12): 5632–9. PMID 1280325.
- Gogate N, Verma L, Zhou JM; et al. (1994). "Plasticity in the adult human oligodendrocyte lineage". J. Neurosci. 14 (8): 4571–87. PMID 7519254.
- Armstrong RC, Kim JG, Hudson LD (1996). "Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes". Glia. 14 (4): 303–21. doi:10.1002/glia.440140407. PMID 8530187.
- Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex". Mol. Cell. Biol. 17 (2): 571–83. PMID 9001210.
- Kim JG, Armstrong RC, v Agoston D; et al. (1998). "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system". J. Neurosci. Res. 50 (2): 272–90. PMID 9373037.
- Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. PMID 10048485.
- Kikuno R, Nagase T, Ishikawa K; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. PMID 10470851.
- Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Hirayama A, Oka A, Ito M; et al. (2003). "Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia". Brain Res. Dev. Brain Res. 140 (1): 85–92. PMID 12524179.
- Nielsen JA, Berndt JA, Hudson LD, Armstrong RC (2004). "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells". Mol. Cell. Neurosci. 25 (1): 111–23. doi:10.1016/j.mcn.2003.10.001. PMID 14962745.
- Vana AC, Lucchinetti CF, Le TQ, Armstrong RC (2007). "Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS". Glia. 55 (7): 687–97. doi:10.1002/glia.20492. PMID 17330875.
External links
- MYT1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.