MYO5A

Myosin VA (heavy chain 12, myoxin)
File:PBB Protein MYO5A image.jpg PDB rendering based on 1oe9.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1oe9​, 1w7i​, 1w7j​, 1w8j​, 2ix7​
Identifiers
Symbols	MYO5A ; GS1; MYH12; MYO5; MYOXIN; MYR12; myosin V; myosin Va
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20100
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MYO5A 204527 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Myosin VA (heavy chain 12, myoxin), also known as MYO5A, is a human gene.

See also

• Myosin

Further reading

• Moore KJ, Testa JR, Francke U; et al. (1995). "Cloning and regional assignment of the human myosin heavy chain 12 (MYH12) gene to chromosome band 15q21". Cytogenet. Cell Genet. 69 (1–2): 53–8. PMID 7835087.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bement WM, Hasson T, Wirth JA; et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. PMID 8022818.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Engle LJ, Kennett RH (1994). "Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene". Genomics. 19 (3): 407–16. doi:10.1006/geno.1994.1088. PMID 8188282.
• Pastural E, Barrat FJ, Dufourcq-Lagelouse R; et al. (1997). "Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene". Nat. Genet. 16 (3): 289–92. doi:10.1038/ng0797-289. PMID 9207796.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lambert J, Naeyaert JM, Callens T; et al. (1998). "Human myosin V gene produces different transcripts in a cell type-specific manner". Biochem. Biophys. Res. Commun. 252 (2): 329–33. doi:10.1006/bbrc.1998.9644. PMID 9826529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Buss F, Kendrick-Jones J, Lionne C; et al. (1999). "The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation". J. Cell Biol. 143 (6): 1535–45. PMID 9852149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• El-Husseini AE, Vincent SR (1999). "Cloning and characterization of a novel RING finger protein that interacts with class V myosins". J. Biol. Chem. 274 (28): 19771–7. PMID 10391919.
• Mehta AD, Rock RS, Rief M; et al. (1999). "Myosin-V is a processive actin-based motor". Nature. 400 (6744): 590–3. doi:10.1038/23072. PMID 10448864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Edgar AJ, Bennett JP (1999). "Inhibition of dendrite formation in mouse melanocytes transiently transfected with antisense DNA to myosin Va". J. Anat. 195 ( Pt 2): 173–84. PMID 10529054.
• Pastural E, Ersoy F, Yalman N; et al. (2000). "Two genes are responsible for Griscelli syndrome at the same 15q21 locus". Genomics. 63 (3): 299–306. doi:10.1006/geno.1999.6081. PMID 10704277.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lambert J, Naeyaert JM, De Paepe A; et al. (2000). "arg-cys substitution at codon 1246 of the human myosin Va gene is not associated with Griscelli syndrome". J. Invest. Dermatol. 114 (4): 731–3. doi:10.1046/j.1523-1747.2000.00933.x. PMID 10733681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Naisbitt S, Valtschanoff J, Allison DW; et al. (2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. 20 (12): 4524–34. PMID 10844022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lo KW, Naisbitt S, Fan JS; et al. (2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". J. Biol. Chem. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohkawa N, Kokura K, Matsu-Ura T; et al. (2001). "Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family is a candidate for the partner of myosin V.". J. Neurochem. 78 (1): 75–87. PMID 11432975.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fukuda M, Kuroda TS, Mikoshiba K (2002). "Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport". J. Biol. Chem. 277 (14): 12432–6. doi:10.1074/jbc.C200005200. PMID 11856727.CS1 maint: Multiple names: authors list (link)
• Rodriguez OC, Cheney RE (2002). "Human myosin-Vc is a novel class V myosin expressed in epithelial cells". J. Cell. Sci. 115 (Pt 5): 991–1004. PMID 11870218.
• Strom M, Hume AN, Tarafder AK; et al. (2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". J. Biol. Chem. 277 (28): 25423–30. doi:10.1074/jbc.M202574200. PMID 11980908.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu X, Wang F, Rao K; et al. (2002). "Rab27a is an essential component of melanosome receptor for myosin Va". Mol. Biol. Cell. 13 (5): 1735–49. doi:10.1091/mbc.01-12-0595. PMID 12006666.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anikster Y, Huizing M, Anderson PD; et al. (2002). "Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A". Am. J. Hum. Genet. 71 (2): 407–14. PMID 12058346.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagashima K, Torii S, Yi Z; et al. (2002). "Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions". FEBS Lett. 517 (1–3): 233–8. PMID 12062444.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)