MYH6

Myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)
File:PBB Protein MYH6 image.jpg PDB rendering based on 2fxm.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2fxm​, 2fxo​
Identifiers
Symbols	MYH6 ; ASD3; MYHC; MYHCA; alpha-MHC
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37626
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MYH6 204737 s at tn.png
File:PBB GE MYH6 214468 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1), also known as MYH6, is a human gene.

Further reading

• Matsuoka R, Beisel KW, Furutani M; et al. (1992). "Complete sequence of human cardiac alpha-myosin heavy chain gene and amino acid comparison to other myosins based on structural and functional differences". Am. J. Med. Genet. 41 (4): 537–47. doi:10.1002/ajmg.1320410435. PMID 1776652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brand NJ, Dabhade N, Yacoub M, Barton PJ (1991). "Determination of the 5' exon structure of the human cardiac alpha-myosin heavy chain gene". Biochem. Biophys. Res. Commun. 179 (3): 1255–8. PMID 1930170.CS1 maint: Multiple names: authors list (link)
• Solomon SD, Geisterfer-Lowrance AA, Vosberg HP; et al. (1990). "A locus for familial hypertrophic cardiomyopathy is closely linked to the cardiac myosin heavy chain genes, CRI-L436, and CRI-L329 on chromosome 14 at q11-q12". Am. J. Hum. Genet. 47 (3): 389–94. PMID 1975475.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ehrlich PH, Moustafa ZA, Ostberg L (1991). "Nucleotide sequence of chimpanzee Fc and hinge regions". Mol. Immunol. 28 (4–5): 319–22. PMID 2062315.CS1 maint: Multiple names: authors list (link)
• Tanigawa G, Jarcho JA, Kass S; et al. (1990). "A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene". Cell. 62 (5): 991–8. PMID 2144212.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsuoka R, Yoshida MC, Kanda N; et al. (1989). "Human cardiac myosin heavy chain gene mapped within chromosome region 14q11.2----q13". Am. J. Med. Genet. 32 (2): 279–84. doi:10.1002/ajmg.1320320234. PMID 2494889.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamauchi-Takihara K, Sole MJ, Liew J; et al. (1989). "Characterization of human cardiac myosin heavy chain genes". Proc. Natl. Acad. Sci. U.S.A. 86 (10): 3504–8. PMID 2726733.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kurabayashi M, Tsuchimochi H, Komuro I; et al. (1988). "Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium". J. Clin. Invest. 82 (2): 524–31. PMID 2969919.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saez LJ, Gianola KM, McNally EM; et al. (1987). "Human cardiac myosin heavy chain genes and their linkage in the genome". Nucleic Acids Res. 15 (13): 5443–59. PMID 3037493.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Epp TA, Dixon IM, Wang HY; et al. (1994). "Structural organization of the human cardiac alpha-myosin heavy chain gene (MYH6)". Genomics. 18 (3): 505–9. PMID 8307559.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shoeman RL, Sachse C, Höner B; et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221–30. PMID 8424456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakao K, Minobe W, Roden R; et al. (1997). "Myosin heavy chain gene expression in human heart failure". J. Clin. Invest. 100 (9): 2362–70. PMID 9410916.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heidkamp MC, Russell B (2002). "Calcium not strain regulates localization of alpha-myosin heavy chain mRNA in oriented cardiac myocytes". Cell Tissue Res. 305 (1): 121–7. PMID 11512664.
• Niimura H, Patton KK, McKenna WJ; et al. (2002). "Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly". Circulation. 105 (4): 446–51. PMID 11815426.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gupta M, Sueblinvong V, Raman J; et al. (2004). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure". J. Biol. Chem. 278 (45): 44935–48. doi:10.1074/jbc.M307696200. PMID 12933792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Narolska NA, van Loon RB, Boontje NM; et al. (2005). "Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue". Cardiovasc. Res. 65 (1): 221–9. doi:10.1016/j.cardiores.2004.09.029. PMID 15621050.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ching YH, Ghosh TK, Cross SJ; et al. (2005). "Mutation in myosin heavy chain 6 causes atrial septal defect". Nat. Genet. 37 (4): 423–8. doi:10.1038/ng1526. PMID 15735645.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carniel E, Taylor MR, Sinagra G; et al. (2006). "Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy". Circulation. 112 (1): 54–9. doi:10.1161/CIRCULATIONAHA.104.507699. PMID 15998695.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Narolska NA, Eiras S, van Loon RB; et al. (2006). "Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium". J. Muscle Res. Cell. Motil. 26 (1): 39–48. doi:10.1007/s10974-005-9005-x. PMID 16088376.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)