MYH11

Myosin, heavy chain 11, smooth muscle
File:PBB Protein MYH11 image.jpg PDB rendering based on 1br1.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1br1​, 1br2​, 1br4​, 1i84​
Identifiers
Symbols	MYH11 ; AAT4; DKFZp686D10126; DKFZp686D19237; FAA4; FLJ35232; MGC126726; MGC32963; SMHC; SMMHC
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68258
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MYH11 201496 x at tn.png
File:PBB GE MYH11 201495 x at tn.png
File:PBB GE MYH11 201497 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Myosin, heavy chain 11, smooth muscle, also known as MYH11, is a human gene.

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Babu GJ, Warshaw DM, Periasamy M (2000). "Smooth muscle myosin heavy chain isoforms and their role in muscle physiology". Microsc. Res. Tech. 50 (6): 532–40. doi:10.1002/1097-0029(20000915)50:6<532::AID-JEMT10>3.0.CO;2-E. PMID 10998642.CS1 maint: Multiple names: authors list (link)
• Matsuoka R, Yoshida MC, Furutani Y; et al. (1993). "Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12". Am. J. Med. Genet. 46 (1): 61–7. doi:10.1002/ajmg.1320460110. PMID 7684189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Aikawa M, Sivam PN, Kuro-o M; et al. (1993). "Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis". Circ. Res. 73 (6): 1000–12. PMID 7916668.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van der Reijden BA, Dauwerse JG, Wessels JW; et al. (1993). "A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in acute nonlymphocytic leukemia M4Eo". Blood. 82 (10): 2948–52. PMID 8219185.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deng Z, Liu P, Marlton P; et al. (1994). "Smooth muscle myosin heavy chain locus (MYH11) maps to 16p13.13-p13.12 and establishes a new region of conserved synteny between human 16p and mouse 16". Genomics. 18 (1): 156–9. doi:10.1006/geno.1993.1443. PMID 8276405.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shoeman RL, Sachse C, Höner B; et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221–30. PMID 8424456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• New L, Jiang Y, Zhao M; et al. (1998). "PRAK, a novel protein kinase regulated by the p38 MAP kinase". EMBO J. 17 (12): 3372–84. doi:10.1093/emboj/17.12.3372. PMID 9628874.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka Y, Fujii M, Hayashi K; et al. (1998). "The chimeric protein, PEBP2 beta/CBF beta-SMMHC, disorganizes cytoplasmic stress fibers and inhibits transcriptional activation". Oncogene. 17 (6): 699–708. doi:10.1038/sj.onc.1201985. PMID 9715271.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. PMID 10048485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsuchio Y, Naito S, Nogami A; et al. (2000). "Intracoronary serum smooth muscle myosin heavy chain levels following PTCA may predict restenosis". Japanese heart journal. 41 (2): 131–40. PMID 10850529.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin VK, Wang D, Lee IL; et al. (2000). "Myosin heavy chain gene expression in normal and hyperplastic human prostate tissue". Prostate. 44 (3): 193–203. PMID 10906735.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Meloni I, Rubegni P, De Aloe G; et al. (2001). "Pseudoxanthoma elasticum: Point mutations in the ABCC6 gene and a large deletion including also ABCC1 and MYH11". Hum. Mutat. 18 (1): 85. doi:10.1002/humu.1157. PMID 11439001.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kundu M, Chen A, Anderson S; et al. (2002). "Role of Cbfb in hematopoiesis and perturbations resulting from expression of the leukemogenic fusion gene Cbfb-MYH11". Blood. 100 (7): 2449–56. doi:10.1182/blood-2002-04-1064. PMID 12239155.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Landrette SF, Kuo YH, Hensen K; et al. (2005). "Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11". Blood. 105 (7): 2900–7. doi:10.1182/blood-2004-09-3630. PMID 15585652.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Léguillette R, Gil FR, Zitouni N; et al. (2005). "(+)Insert smooth muscle myosin heavy chain (SM-B) isoform expression in human tissues". Am. J. Physiol., Cell Physiol. 289 (5): C1277–85. doi:10.1152/ajpcell.00244.2004. PMID 16000639.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu L, Vranckx R, Khau Van Kien P; et al. (2006). "Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus". Nat. Genet. 38 (3): 343–9. doi:10.1038/ng1721. PMID 16444274.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)