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{{Infobox_gene}}
{{Infobox_gene}}
'''Mitochondrial tumor suppressor 1''' is a [[protein]] that in humans is encoded by the ''MTUS1'' [[gene]].<ref name="pmid10574462">{{cite journal | vauthors = Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 5 | pages = 337–45 | date = Oct 1999 | pmid = 10574462 | pmc =  | doi = 10.1093/dnares/6.5.337 }}</ref><ref name="pmid12692079">{{cite journal | vauthors = Seibold S, Rudroff C, Weber M, Galle J, Wanner C, Marx M | title = Identification of a new tumor suppressor gene located at chromosome 8p21.3-22 | journal = FASEB Journal | volume = 17 | issue = 9 | pages = 1180–2 | date = Jun 2003 | pmid = 12692079 | pmc =  | doi = 10.1096/fj.02-0934fje }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MTUS1 mitochondrial tumor suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57509| accessdate = }}</ref>
'''Mitochondrial tumor suppressor 1 (MTSG1)''' or '''Microtubule-Associated Scaffold Protein 1''' ('''''MTUS1''''') is a [[protein|candidate tumor suppressor protein]] encoded by the ''MTUS1'' [[gene]] in humans.<ref>{{cite journal | vauthors = Kara M, Kaplan M, Bozgeyik I, Ozcan O, Celik OI, Bozgeyik E, Yumrutas O | title = MTUS1 tumor suppressor and its miRNA regulators in fibroadenoma and breast cancer | journal = Gene | volume = 587 | issue = 2 | pages = 173–7 | date = August 2016 | pmid = 27155522 | doi = 10.1016/j.gene.2016.05.006 }}</ref><ref>{{cite journal | vauthors = Bozgeyik I, Yumrutas O, Bozgeyik E | title = MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis | journal = Gene | volume = 626 | pages = 54–63 | date = August 2017 | pmid = 28499941 | doi = 10.1016/j.gene.2017.05.019 }}</ref> Expression levels of MTUS1 was reported to be lost in various types of human malignancies such as colon, ovarian, head-and-neck, pancreas, breast cancers, bladder, gastric, and lung cancers.<ref>{{cite journal | vauthors = Bozgeyik I, Yumrutas O, Bozgeyik E | title = MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis | journal = Gene | volume = 626 | pages = 54–63 | date = August 2017 | pmid = 28499941 | doi = 10.1016/j.gene.2017.05.019 }}</ref><ref>{{cite journal | vauthors = Ozcan O, Kara M, Yumrutas O, Bozgeyik E, Bozgeyik I, Celik OI | title = MTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations | journal = Tumour Biology | volume = 37 | issue = 5 | pages = 6637–45 | date = May 2016 | pmid = 26643896 | doi = 10.1007/s13277-015-4550-4 }}</ref>
 
== Proteins encoded by MTUS1 ==
As a result of alternative splicing MTUS1 was shown to encode 5 different protein isoforms as listed as ATIP1, ATIP2, ATIP3a, ATIP3b and ATIP4. ATIP3a and ATIP3b was generally considered as ATIP3 and ATIP1 and ATIP3 is the major splice variants encoded by MTUS1 gene.<ref>{{cite journal | vauthors = Bozgeyik I, Yumrutas O, Bozgeyik E | title = MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis | journal = Gene | volume = 626 | pages = 54–63 | date = August 2017 | pmid = 28499941 | doi = 10.1016/j.gene.2017.05.019 }}</ref>  


== Function ==
== Function ==


This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and participates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.<ref name="entrez"/>
This gene encodes a protein which contains a C-terminal domain able to interact with the [[angiotensin II receptor type 2]] (AT2) and a large [[coiled-coil]] region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a [[tumor suppressor]] and participates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.<ref name="entrez">{{cite web | title = Entrez Gene: MTUS1 mitochondrial tumor suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57509  }}</ref>


== Interactions ==
== Interactions ==


MTUS1 has been shown to [[Protein-protein interaction|interact]] with [[Angiotensin II receptor type 2]].<ref name=pmid15123706>{{cite journal | vauthors = Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C | title = Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP | journal = The Journal of Biological Chemistry | volume = 279 | issue = 28 | pages = 28989–97 | date = Jul 2004 | pmid = 15123706 | doi = 10.1074/jbc.M403880200 }}</ref>
MTUS1 has been shown to [[Protein-protein interaction|interact]] with [[Angiotensin II receptor type 2]].<ref name=pmid15123706>{{cite journal | vauthors = Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C | title = Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP | journal = The Journal of Biological Chemistry | volume = 279 | issue = 28 | pages = 28989–97 | date = July 2004 | pmid = 15123706 | doi = 10.1074/jbc.M403880200 }}</ref>


== References ==
== References ==
Line 15: Line 18:
== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Di Benedetto M, Pineau P, Nouet S, Berhouet S, Seitz I, Louis S, Dejean A, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Nahmias C | title = Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma | journal = Molecular and Cellular Endocrinology | volume = 252 | issue = 1-2 | pages = 207–15 | date = Jun 2006 | pmid = 16650523 | doi = 10.1016/j.mce.2006.03.014 }}
* {{cite journal | vauthors = Di Benedetto M, Pineau P, Nouet S, Berhouet S, Seitz I, Louis S, Dejean A, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Nahmias C | title = Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma | journal = Molecular and Cellular Endocrinology | volume = 252 | issue = 1-2 | pages = 207–15 | date = June 2006 | pmid = 16650523 | doi = 10.1016/j.mce.2006.03.014 }}
* {{cite journal | vauthors = Frank B, Bermejo JL, Hemminki K, Sutter C, Wappenschmidt B, Meindl A, Kiechle-Bahat M, Bugert P, Schmutzler RK, Bartram CR, Burwinkel B | title = Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk | journal = Carcinogenesis | volume = 28 | issue = 7 | pages = 1442–5 | date = Jul 2007 | pmid = 17301065 | doi = 10.1093/carcin/bgm033 }}
* {{cite journal | vauthors = Frank B, Bermejo JL, Hemminki K, Sutter C, Wappenschmidt B, Meindl A, Kiechle-Bahat M, Bugert P, Schmutzler RK, Bartram CR, Burwinkel B | title = Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk | journal = Carcinogenesis | volume = 28 | issue = 7 | pages = 1442–5 | date = July 2007 | pmid = 17301065 | doi = 10.1093/carcin/bgm033 }}
* {{cite journal | vauthors = Di Benedetto M, Bièche I, Deshayes F, Vacher S, Nouet S, Collura V, Seitz I, Louis S, Pineau P, Amsellem-Ouazana D, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Lidereau R, Nahmias C | title = Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP | journal = Gene | volume = 380 | issue = 2 | pages = 127–36 | date = Oct 2006 | pmid = 16887298 | doi = 10.1016/j.gene.2006.05.021 }}
* {{cite journal | vauthors = Di Benedetto M, Bièche I, Deshayes F, Vacher S, Nouet S, Collura V, Seitz I, Louis S, Pineau P, Amsellem-Ouazana D, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Lidereau R, Nahmias C | title = Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP | journal = Gene | volume = 380 | issue = 2 | pages = 127–36 | date = October 2006 | pmid = 16887298 | doi = 10.1016/j.gene.2006.05.021 }}
* {{cite journal | vauthors = Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C | title = Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP | journal = The Journal of Biological Chemistry | volume = 279 | issue = 28 | pages = 28989–97 | date = Jul 2004 | pmid = 15123706 | doi = 10.1074/jbc.M403880200 }}
* {{cite journal | vauthors = Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C | title = Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP | journal = The Journal of Biological Chemistry | volume = 279 | issue = 28 | pages = 28989–97 | date = July 2004 | pmid = 15123706 | doi = 10.1074/jbc.M403880200 }}
{{refend}}
{{refend}}


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{{gene-8-stub}}

Latest revision as of 08:48, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
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Mitochondrial tumor suppressor 1 (MTSG1) or Microtubule-Associated Scaffold Protein 1 (MTUS1) is a candidate tumor suppressor protein encoded by the MTUS1 gene in humans.[1][2] Expression levels of MTUS1 was reported to be lost in various types of human malignancies such as colon, ovarian, head-and-neck, pancreas, breast cancers, bladder, gastric, and lung cancers.[3][4]

Proteins encoded by MTUS1

As a result of alternative splicing MTUS1 was shown to encode 5 different protein isoforms as listed as ATIP1, ATIP2, ATIP3a, ATIP3b and ATIP4. ATIP3a and ATIP3b was generally considered as ATIP3 and ATIP1 and ATIP3 is the major splice variants encoded by MTUS1 gene.[5]

Function

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotensin II receptor type 2 (AT2) and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and participates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways.[6]

Interactions

MTUS1 has been shown to interact with Angiotensin II receptor type 2.[7]

References

  1. ↑ Kara M, Kaplan M, Bozgeyik I, Ozcan O, Celik OI, Bozgeyik E, Yumrutas O (August 2016). "MTUS1 tumor suppressor and its miRNA regulators in fibroadenoma and breast cancer". Gene. 587 (2): 173–7. doi:10.1016/j.gene.2016.05.006. PMID 27155522.
  2. ↑ Bozgeyik I, Yumrutas O, Bozgeyik E (August 2017). "MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis". Gene. 626: 54–63. doi:10.1016/j.gene.2017.05.019. PMID 28499941.
  3. ↑ Bozgeyik I, Yumrutas O, Bozgeyik E (August 2017). "MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis". Gene. 626: 54–63. doi:10.1016/j.gene.2017.05.019. PMID 28499941.
  4. ↑ Ozcan O, Kara M, Yumrutas O, Bozgeyik E, Bozgeyik I, Celik OI (May 2016). "MTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations". Tumour Biology. 37 (5): 6637–45. doi:10.1007/s13277-015-4550-4. PMID 26643896.
  5. ↑ Bozgeyik I, Yumrutas O, Bozgeyik E (August 2017). "MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis". Gene. 626: 54–63. doi:10.1016/j.gene.2017.05.019. PMID 28499941.
  6. ↑ "Entrez Gene: MTUS1 mitochondrial tumor suppressor 1".
  7. ↑ Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (July 2004). "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP". The Journal of Biological Chemistry. 279 (28): 28989–97. doi:10.1074/jbc.M403880200. PMID 15123706.

Further reading

  • Di Benedetto M, Pineau P, Nouet S, Berhouet S, Seitz I, Louis S, Dejean A, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Nahmias C (June 2006). "Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma". Molecular and Cellular Endocrinology. 252 (1–2): 207–15. doi:10.1016/j.mce.2006.03.014. PMID 16650523.
  • Frank B, Bermejo JL, Hemminki K, Sutter C, Wappenschmidt B, Meindl A, Kiechle-Bahat M, Bugert P, Schmutzler RK, Bartram CR, Burwinkel B (July 2007). "Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk". Carcinogenesis. 28 (7): 1442–5. doi:10.1093/carcin/bgm033. PMID 17301065.
  • Di Benedetto M, Bièche I, Deshayes F, Vacher S, Nouet S, Collura V, Seitz I, Louis S, Pineau P, Amsellem-Ouazana D, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Lidereau R, Nahmias C (October 2006). "Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP". Gene. 380 (2): 127–36. doi:10.1016/j.gene.2006.05.021. PMID 16887298.
  • Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (July 2004). "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP". The Journal of Biological Chemistry. 279 (28): 28989–97. doi:10.1074/jbc.M403880200. PMID 15123706.
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