MMP9

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
File:PBB Protein MMP9 image.jpg PDB rendering based on 1itv.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1itv​, 1l6j​
Identifiers
Symbols	MMP9 ; CLG4B; GELB; MMP-9
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3659
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MMP9 203936 s at.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), also known as MMP9, is a human enzyme.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.

Further reading

• Nagase H, Woessner JF (1999). "Matrix metalloproteinases". J. Biol. Chem. 274 (31): 21491–4. PMID 10419448.
• Starckx S, Van den Steen PE, Wuyts A; et al. (2003). "Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization". Leuk. Lymphoma. 43 (2): 233–41. PMID 11999552.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bischof P, Meisser A, Campana A (2002). "Control of MMP-9 expression at the maternal-fetal interface". J. Reprod. Immunol. 55 (1–2): 3–10. PMID 12062817.CS1 maint: Multiple names: authors list (link)
• St-Pierre Y, Van Themsche C, Estève PO (2003). "Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies". Current drug targets. Inflammation and allergy. 2 (3): 206–15. PMID 14561155.CS1 maint: Multiple names: authors list (link)
• Lee JM, Yin K, Hsin I; et al. (2005). "Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage". J. Neurol. Sci. 229-230: 249–54. doi:10.1016/j.jns.2004.11.041. PMID 15760647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nair RR, Boyd DD (2006). "Expression cloning of novel regulators of 92 kDa type IV collagenase expression". Biochem. Soc. Trans. 33 (Pt 5): 1135–6. doi:10.1042/BST20051135. PMID 16246065.
• Ram M, Sherer Y, Shoenfeld Y (2006). "Matrix metalloproteinase-9 and autoimmune diseases". J. Clin. Immunol. 26 (4): 299–307. doi:10.1007/s10875-006-9022-6. PMID 16652230.CS1 maint: Multiple names: authors list (link)