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Matrix metalloproteinase-23 is an enzyme that in humans is encoded by the MMP23Bgene.[1][2][3]
This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the copy of the duplicated region of the gene that is closer to the end of the chromosome (more telemeric).[3]
↑Gururajan R, Grenet J, Lahti JM, Kidd VJ (May 1999). "Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3". Genomics. 52 (1): 101–6. doi:10.1006/geno.1998.5401. PMID9740677.
Velasco G, Pendás AM, Fueyo A, et al. (1999). "Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members". J. Biol. Chem. 274 (8): 4570–6. doi:10.1074/jbc.274.8.4570. PMID9988691.
Terp GE, Christensen IT, Jørgensen FS (2000). "Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes". J. Biomol. Struct. Dyn. 17 (6): 933–46. doi:10.1080/07391102.2000.10506582. PMID10949161.
Ohnishi J, Ohnishi E, Jin M, et al. (2001). "Cloning and characterization of a rat ortholog of MMP-23 (matrix metalloproteinase-23), a unique type of membrane-anchored matrix metalloproteinase and conditioned switching of its expression during the ovarian follicular development". Mol. Endocrinol. 15 (5): 747–64. doi:10.1210/me.15.5.747. PMID11328856.
Gajecka M, Yu W, Ballif BC, et al. (2005). "Delineation of mechanisms and regions of dosage imbalance in complex rearrangements of 1p36 leads to a putative gene for regulation of cranial suture closure". Eur. J. Hum. Genet. 13 (2): 139–49. doi:10.1038/sj.ejhg.5201302. PMID15483646.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID16710414.
External links
The MEROPS online database for peptidases and their inhibitors: M10.022
