MLLT3: Difference between revisions

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{{Infobox_gene}}
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'''Protein AF-9''' is a [[protein]] that in humans is encoded by the ''MLLT3'' [[gene]].<ref name="pmid8506309">{{cite journal |vauthors=Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC | title = Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 10 | pages = 4631–5 |date=Jul 1993 | pmid = 8506309 | pmc = 46566 | doi =10.1073/pnas.90.10.4631 |display-authors=etal}}</ref><ref name="pmid8414510">{{cite journal |vauthors=Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R | title = MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13 | journal = Oncogene | volume = 8 | issue = 11 | pages = 3085–92 |date=Nov 1993 | pmid = 8414510 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4300| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
| HGNCid = 7136
| Symbol = MLLT3
| AltSymbols =; AF9; FLJ2035; YEATS3
| OMIM = 159558
| ECnumber =
| Homologene = 37933
| MGIid = 1917372
| GeneAtlas_image1 = PBB_GE_MLLT3_204918_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MLLT3_204917_s_at_tn.png
  | Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007379 |text = segment specification}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4300
    | Hs_Ensembl = ENSG00000171843
    | Hs_RefseqProtein = NP_004520
    | Hs_RefseqmRNA = NM_004529
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 20331663
    | Hs_GenLoc_end = 20612542
    | Hs_Uniprot = P42568
    | Mm_EntrezGene = 70122
    | Mm_Ensembl = ENSMUSG00000028496
    | Mm_RefseqmRNA = NM_027326
    | Mm_RefseqProtein = NP_081602
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 87243884
    | Mm_GenLoc_end = 87504503
    | Mm_Uniprot =   
  }}
}}
'''Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3''', also known as '''MLLT3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4300| accessdate = }}</ref>


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| summary_text =  
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==Interactions==
MLLT3 has been shown to [[Protein-protein interaction|interact]] with [[BCL-6 corepressor|BCOR]].<ref name=pmid12776190>{{cite journal |last=Srinivasan |first=R Sathish |authorlink= |author2=de Erkenez Andrea C |author3=Hemenway Charles S  |date=May 2003 |title=The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor |journal=Oncogene |volume=22 |issue=22 |pages=3395–406 |publisher= |location = England| issn = 0950-9232| pmid = 12776190 |doi = 10.1038/sj.onc.1206361 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Iida S, Seto M, Yamamoto K, ''et al.'' |title=MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. |journal=Oncogene |volume=8 |issue= 11 |pages= 3085-92 |year= 1993 |pmid= 8414510 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Nakamura T, Alder H, Gu Y, ''et al.'' |title=Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 10 |pages= 4631-5 |year= 1993 |pmid= 8506309 |doi=  }}
*{{cite journal  |vauthors=Huynh KD, Fischle W, Verdin E, Bardwell VJ |title=BCoR, a novel corepressor involved in BCL-6 repression. |journal=Genes Dev. |volume=14 |issue= 14 |pages= 1810–23 |year= 2000 |pmid= 10898795 |doi= 10.1101/gad.14.14.1810| pmc=316791 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=García-Cuéllar MP, Zilles O, Schreiner SA, etal |title=The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. |journal=Oncogene |volume=20 |issue= 4 |pages= 411–9 |year= 2001 |pmid= 11313972 |doi= 10.1038/sj.onc.1204108 }}
*{{cite journal  | author=Huynh KD, Fischle W, Verdin E, Bardwell VJ |title=BCoR, a novel corepressor involved in BCL-6 repression. |journal=Genes Dev. |volume=14 |issue= 14 |pages= 1810-23 |year= 2000 |pmid= 10898795 |doi=  }}
*{{cite journal  |vauthors=Hemenway CS, de Erkenez AC, Gould GC |title=The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. |journal=Oncogene |volume=20 |issue= 29 |pages= 3798–805 |year= 2001 |pmid= 11439343 |doi= 10.1038/sj.onc.1204478 }}
*{{cite journal | author=García-Cuéllar MP, Zilles O, Schreiner SA, ''et al.'' |title=The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. |journal=Oncogene |volume=20 |issue= 4 |pages= 411-9 |year= 2001 |pmid= 11313972 |doi= 10.1038/sj.onc.1204108 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Hemenway CS, de Erkenez AC, Gould GC |title=The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. |journal=Oncogene |volume=20 |issue= 29 |pages= 3798-805 |year= 2001 |pmid= 11439343 |doi= 10.1038/sj.onc.1204478 }}
*{{cite journal  |vauthors=Srinivasan RS, de Erkenez AC, Hemenway CS |title=The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor. |journal=Oncogene |volume=22 |issue= 22 |pages= 3395–406 |year= 2003 |pmid= 12776190 |doi= 10.1038/sj.onc.1206361 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Erfurth F, Hemenway CS, de Erkenez AC, Domer PH |title=MLL fusion partners AF4 and AF9 interact at subnuclear foci. |journal=Leukemia |volume=18 |issue= 1 |pages= 92–102 |year= 2004 |pmid= 14603337 |doi= 10.1038/sj.leu.2403200 }}
*{{cite journal  | author=Srinivasan RS, de Erkenez AC, Hemenway CS |title=The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor. |journal=Oncogene |volume=22 |issue= 22 |pages= 3395-406 |year= 2003 |pmid= 12776190 |doi= 10.1038/sj.onc.1206361 }}
*{{cite journal   |vauthors=Montemurro L, Tonelli R, Fazzina R, etal |title=Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line. |journal=Cancer Genet. Cytogenet. |volume=154 |issue= 1 |pages= 96–7 |year= 2004 |pmid= 15381384 |doi= 10.1016/j.cancergencyto.2004.01.029 }}
*{{cite journal  | author=Erfurth F, Hemenway CS, de Erkenez AC, Domer PH |title=MLL fusion partners AF4 and AF9 interact at subnuclear foci. |journal=Leukemia |volume=18 |issue= 1 |pages= 92-102 |year= 2004 |pmid= 14603337 |doi= 10.1038/sj.leu.2403200 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Montemurro L, Tonelli R, Fazzina R, ''et al.'' |title=Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line. |journal=Cancer Genet. Cytogenet. |volume=154 |issue= 1 |pages= 96-7 |year= 2004 |pmid= 15381384 |doi= 10.1016/j.cancergencyto.2004.01.029 }}
*{{cite journal   |vauthors=Martino V, Tonelli R, Montemurro L, etal |title=Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23). |journal=Oncol. Rep. |volume=15 |issue= 1 |pages= 207–11 |year= 2006 |pmid= 16328057 |doi=  10.3892/or.15.1.207}}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Martino V, Tonelli R, Montemurro L, ''et al.'' |title=Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23). |journal=Oncol. Rep. |volume=15 |issue= 1 |pages= 207-11 |year= 2006 |pmid= 16328057 |doi=  }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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Revision as of 06:38, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein AF-9 is a protein that in humans is encoded by the MLLT3 gene.[1][2][3]


Interactions

MLLT3 has been shown to interact with BCOR.[4]

References

  1. ↑ Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, et al. (Jul 1993). "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs". Proc Natl Acad Sci U S A. 90 (10): 4631–5. doi:10.1073/pnas.90.10.4631. PMC 46566. PMID 8506309.
  2. ↑ Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R (Nov 1993). "MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13". Oncogene. 8 (11): 3085–92. PMID 8414510.
  3. ↑ "Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3".
  4. ↑ Srinivasan, R Sathish; de Erkenez Andrea C; Hemenway Charles S (May 2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene. England. 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. ISSN 0950-9232. PMID 12776190.

Further reading



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