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'''Protein AF-9''' is a [[protein]] that in humans is encoded by the ''MLLT3'' [[gene]].<ref name="pmid8506309">{{cite journal |vauthors=Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC | title = Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 10 | pages = 4631–5 |date=Jul 1993 | pmid = 8506309 | pmc = 46566 | doi =10.1073/pnas.90.10.4631 |display-authors=etal}}</ref><ref name="pmid8414510">{{cite journal |vauthors=Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R | title = MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13 | journal = Oncogene | volume = 8 | issue = 11 | pages = 3085–92 |date=Nov 1993 | pmid = 8414510 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4300| accessdate = }}</ref> | '''Protein AF-9''' is a [[protein]] that in humans is encoded by the ''MLLT3'' [[gene]].<ref name="pmid8506309">{{cite journal |vauthors=Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC | title = Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 10 | pages = 4631–5 |date=Jul 1993 | pmid = 8506309 | pmc = 46566 | doi =10.1073/pnas.90.10.4631 |display-authors=etal|bibcode=1993PNAS...90.4631N }}</ref><ref name="pmid8414510">{{cite journal |vauthors=Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R | title = MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13 | journal = Oncogene | volume = 8 | issue = 11 | pages = 3085–92 |date=Nov 1993 | pmid = 8414510 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4300| accessdate = }}</ref> | ||
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*{{cite journal |vauthors=García-Cuéllar MP, Zilles O, Schreiner SA, etal |title=The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. |journal=Oncogene |volume=20 |issue= 4 |pages= 411–9 |year= 2001 |pmid= 11313972 |doi= 10.1038/sj.onc.1204108 }} | *{{cite journal |vauthors=García-Cuéllar MP, Zilles O, Schreiner SA, etal |title=The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. |journal=Oncogene |volume=20 |issue= 4 |pages= 411–9 |year= 2001 |pmid= 11313972 |doi= 10.1038/sj.onc.1204108 }} | ||
*{{cite journal |vauthors=Hemenway CS, de Erkenez AC, Gould GC |title=The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. |journal=Oncogene |volume=20 |issue= 29 |pages= 3798–805 |year= 2001 |pmid= 11439343 |doi= 10.1038/sj.onc.1204478 }} | *{{cite journal |vauthors=Hemenway CS, de Erkenez AC, Gould GC |title=The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias. |journal=Oncogene |volume=20 |issue= 29 |pages= 3798–805 |year= 2001 |pmid= 11439343 |doi= 10.1038/sj.onc.1204478 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Srinivasan RS, de Erkenez AC, Hemenway CS |title=The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor. |journal=Oncogene |volume=22 |issue= 22 |pages= 3395–406 |year= 2003 |pmid= 12776190 |doi= 10.1038/sj.onc.1206361 }} | *{{cite journal |vauthors=Srinivasan RS, de Erkenez AC, Hemenway CS |title=The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor. |journal=Oncogene |volume=22 |issue= 22 |pages= 3395–406 |year= 2003 |pmid= 12776190 |doi= 10.1038/sj.onc.1206361 }} | ||
*{{cite journal |vauthors=Erfurth F, Hemenway CS, de Erkenez AC, Domer PH |title=MLL fusion partners AF4 and AF9 interact at subnuclear foci. |journal=Leukemia |volume=18 |issue= 1 |pages= 92–102 |year= 2004 |pmid= 14603337 |doi= 10.1038/sj.leu.2403200 }} | *{{cite journal |vauthors=Erfurth F, Hemenway CS, de Erkenez AC, Domer PH |title=MLL fusion partners AF4 and AF9 interact at subnuclear foci. |journal=Leukemia |volume=18 |issue= 1 |pages= 92–102 |year= 2004 |pmid= 14603337 |doi= 10.1038/sj.leu.2403200 }} | ||
*{{cite journal |vauthors=Montemurro L, Tonelli R, Fazzina R, etal |title=Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line. |journal=Cancer Genet. Cytogenet. |volume=154 |issue= 1 |pages= 96–7 |year= 2004 |pmid= 15381384 |doi= 10.1016/j.cancergencyto.2004.01.029 }} | *{{cite journal |vauthors=Montemurro L, Tonelli R, Fazzina R, etal |title=Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line. |journal=Cancer Genet. Cytogenet. |volume=154 |issue= 1 |pages= 96–7 |year= 2004 |pmid= 15381384 |doi= 10.1016/j.cancergencyto.2004.01.029 }} | ||
*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }} | ||
*{{cite journal |vauthors=Martino V, Tonelli R, Montemurro L, etal |title=Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23). |journal=Oncol. Rep. |volume=15 |issue= 1 |pages= 207–11 |year= 2006 |pmid= 16328057 |doi= 10.3892/or.15.1.207}} | *{{cite journal |vauthors=Martino V, Tonelli R, Montemurro L, etal |title=Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23). |journal=Oncol. Rep. |volume=15 |issue= 1 |pages= 207–11 |year= 2006 |pmid= 16328057 |doi= 10.3892/or.15.1.207}} | ||
}} | }} | ||
Latest revision as of 07:37, 10 January 2019
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Protein AF-9 is a protein that in humans is encoded by the MLLT3 gene.[1][2][3]
Interactions
MLLT3 has been shown to interact with BCOR.[4]
References
- ↑ Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, et al. (Jul 1993). "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs". Proc Natl Acad Sci U S A. 90 (10): 4631–5. Bibcode:1993PNAS...90.4631N. doi:10.1073/pnas.90.10.4631. PMC 46566. PMID 8506309.
- ↑ Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R (Nov 1993). "MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13". Oncogene. 8 (11): 3085–92. PMID 8414510.
- ↑ "Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3".
- ↑ Srinivasan, R Sathish; de Erkenez Andrea C; Hemenway Charles S (May 2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene. England. 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. ISSN 0950-9232. PMID 12776190.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Huynh KD, Fischle W, Verdin E, Bardwell VJ (2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes Dev. 14 (14): 1810–23. doi:10.1101/gad.14.14.1810. PMC 316791. PMID 10898795.
- García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
- Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias". Oncogene. 20 (29): 3798–805. doi:10.1038/sj.onc.1204478. PMID 11439343.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Srinivasan RS, de Erkenez AC, Hemenway CS (2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene. 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. PMID 12776190.
- Erfurth F, Hemenway CS, de Erkenez AC, Domer PH (2004). "MLL fusion partners AF4 and AF9 interact at subnuclear foci". Leukemia. 18 (1): 92–102. doi:10.1038/sj.leu.2403200. PMID 14603337.
- Montemurro L, Tonelli R, Fazzina R, et al. (2004). "Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line". Cancer Genet. Cytogenet. 154 (1): 96–7. doi:10.1016/j.cancergencyto.2004.01.029. PMID 15381384.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
- Martino V, Tonelli R, Montemurro L, et al. (2006). "Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23)". Oncol. Rep. 15 (1): 207–11. doi:10.3892/or.15.1.207. PMID 16328057.
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