MIR494: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''MicroRNA 494''' is a [[microRNA]] that in humans is encoded by the MIR494 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MicroRNA 494
| url = https://www.ncbi.nlm.nih.gov/gene/574452 | access-date = 2017-10-19 }}</ref>


'''MicroRNA 494''' is a [[protein]] that in humans is encoded by the MIR494 [[gene]].
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: MicroRNA 494
| url = http://www.ncbi.nlm.nih.gov/gene/574452
| accessdate = 2017-10-19
}}</ref>
 
==Function==


microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
microRNAs (miRNAs) are short (20-24 nt) [[non-coding RNA]]s that are involved in [[post-transcriptional regulation]] of [[gene expression]] in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by [[RNA polymerase II]] as part of capped and [[polyadenylation|polyadenylated]] primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the [[Drosha|Drosha ribonuclease III]] enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic [[Dicer|Dicer ribonuclease]] to generate the mature miRNA and [[antisense]] miRNA star (miRNA*) products. The mature miRNA is incorporated into a [[RNA-induced silencing complex]] (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. This RefSeq represents the predicted microRNA stem-loop.<ref name="entrez" />


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal |vauthors=Diakos C, Zhong S, Xiao Y, Zhou M, Vasconcelos GM, Krapf G, Yeh RF, Zheng S, Kang M, Wiencke JK, Pombo-de-Oliveira MS, Panzer-Grümayer R, Wiemels JL |title=TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a |journal=Blood |volume=116 |issue=23 |pages=4885–93 |year=2010 |pmid=20807887 |pmc=3265147 |doi=10.1182/blood-2009-02-206706 |url=}}
* {{cite journal | vauthors = Diakos C, Zhong S, Xiao Y, Zhou M, Vasconcelos GM, Krapf G, Yeh RF, Zheng S, Kang M, Wiencke JK, Pombo-de-Oliveira MS, Panzer-Grümayer R, Wiemels JL | title = TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a | journal = Blood | volume = 116 | issue = 23 | pages = 4885–93 | date = December 2010 | pmid = 20807887 | pmc = 3265147 | doi = 10.1182/blood-2009-02-206706 }}
*{{cite journal |vauthors=Olaru AV, Ghiaur G, Yamanaka S, Luvsanjav D, An F, Popescu I, Alexandrescu S, Allen S, Pawlik TM, Torbenson M, Georgiades C, Roberts LR, Gores GJ, Ferguson-Smith A, Almeida MI, Calin GA, Mezey E, Selaru FM |title=MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpoint |journal=Hepatology |volume=54 |issue=6 |pages=2089–98 |year=2011 |pmid=21809359 |pmc=3212606 |doi=10.1002/hep.24591 |url=}}
* {{cite journal | vauthors = Olaru AV, Ghiaur G, Yamanaka S, Luvsanjav D, An F, Popescu I, Alexandrescu S, Allen S, Pawlik TM, Torbenson M, Georgiades C, Roberts LR, Gores GJ, Ferguson-Smith A, Almeida MI, Calin GA, Mezey E, Selaru FM | title = MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpoint | journal = Hepatology | volume = 54 | issue = 6 | pages = 2089–98 | date = December 2011 | pmid = 21809359 | pmc = 3212606 | doi = 10.1002/hep.24591 }}
*{{cite journal |vauthors=Tominaga K, Srikantan S, Lee EK, Subaran SS, Martindale JL, Abdelmohsen K, Gorospe M |title=Competitive regulation of nucleolin expression by HuR and miR-494 |journal=Mol. Cell. Biol. |volume=31 |issue=20 |pages=4219–31 |year=2011 |pmid=21859890 |pmc=3187287 |doi=10.1128/MCB.05955-11 |url=}}
* {{cite journal | vauthors = Tominaga K, Srikantan S, Lee EK, Subaran SS, Martindale JL, Abdelmohsen K, Gorospe M | title = Competitive regulation of nucleolin expression by HuR and miR-494 | journal = Molecular and Cellular Biology | volume = 31 | issue = 20 | pages = 4219–31 | date = October 2011 | pmid = 21859890 | pmc = 3187287 | doi = 10.1128/MCB.05955-11 }}
*{{cite journal |vauthors=Megiorni F, Cialfi S, Dominici C, Quattrucci S, Pizzuti A |title=Synergistic post-transcriptional regulation of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) by miR-101 and miR-494 specific binding |journal=PLoS ONE |volume=6 |issue=10 |pages=e26601 |year=2011 |pmid=22028919 |pmc=3197680 |doi=10.1371/journal.pone.0026601 |url=}}
* {{cite journal | vauthors = Megiorni F, Cialfi S, Dominici C, Quattrucci S, Pizzuti A | title = Synergistic post-transcriptional regulation of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) by miR-101 and miR-494 specific binding | journal = PLOS One | volume = 6 | issue = 10 | pages = e26601 | year = 2011 | pmid = 22028919 | pmc = 3197680 | doi = 10.1371/journal.pone.0026601 }}
*{{cite journal |vauthors=Kim WK, Park M, Kim YK, Tae YK, Yang HK, Lee JM, Kim H |title=MicroRNA-494 downregulates KIT and inhibits gastrointestinal stromal tumor cell proliferation |journal=Clin. Cancer Res. |volume=17 |issue=24 |pages=7584–94 |year=2011 |pmid=22042971 |doi=10.1158/1078-0432.CCR-11-0166 |url=}}
* {{cite journal | vauthors = Kim WK, Park M, Kim YK, Tae YK, Yang HK, Lee JM, Kim H | title = MicroRNA-494 downregulates KIT and inhibits gastrointestinal stromal tumor cell proliferation | journal = Clinical Cancer Research | volume = 17 | issue = 24 | pages = 7584–94 | date = December 2011 | pmid = 22042971 | doi = 10.1158/1078-0432.CCR-11-0166 }}
*{{cite journal |vauthors=Ohdaira H, Sekiguchi M, Miyata K, Yoshida K |title=MicroRNA-494 suppresses cell proliferation and induces senescence in A549 lung cancer cells |journal=Cell Prolif. |volume=45 |issue=1 |pages=32–8 |year=2012 |pmid=22151897 |doi=10.1111/j.1365-2184.2011.00798.x |url=}}
* {{cite journal | vauthors = Ohdaira H, Sekiguchi M, Miyata K, Yoshida K | title = MicroRNA-494 suppresses cell proliferation and induces senescence in A549 lung cancer cells | journal = Cell Proliferation | volume = 45 | issue = 1 | pages = 32–8 | date = February 2012 | pmid = 22151897 | doi = 10.1111/j.1365-2184.2011.00798.x }}
*{{cite journal |vauthors=Yamanaka S, Campbell NR, An F, Kuo SC, Potter JJ, Mezey E, Maitra A, Selaru FM |title=Coordinated effects of microRNA-494 induce G₂/M arrest in human cholangiocarcinoma |journal=Cell Cycle |volume=11 |issue=14 |pages=2729–38 |year=2012 |pmid=22785131 |pmc=3409013 |doi=10.4161/cc.21105 |url=}}
* {{cite journal | vauthors = Yamanaka S, Campbell NR, An F, Kuo SC, Potter JJ, Mezey E, Maitra A, Selaru FM | title = Coordinated effects of microRNA-494 induce G₂/M arrest in human cholangiocarcinoma | journal = Cell Cycle | volume = 11 | issue = 14 | pages = 2729–38 | date = July 2012 | pmid = 22785131 | pmc = 3409013 | doi = 10.4161/cc.21105 }}
*{{cite journal |vauthors=Altmäe S, Martinez-Conejero JA, Esteban FJ, Ruiz-Alonso M, Stavreus-Evers A, Horcajadas JA, Salumets A |title=MicroRNAs miR-30b, miR-30d, and miR-494 regulate human endometrial receptivity |journal=Reprod Sci |volume=20 |issue=3 |pages=308–17 |year=2013 |pmid=22902743 |pmc=4077381 |doi=10.1177/1933719112453507 |url=}}
* {{cite journal | vauthors = Altmäe S, Martinez-Conejero JA, Esteban FJ, Ruiz-Alonso M, Stavreus-Evers A, Horcajadas JA, Salumets A | title = MicroRNAs miR-30b, miR-30d, and miR-494 regulate human endometrial receptivity | journal = Reproductive Sciences | volume = 20 | issue = 3 | pages = 308–17 | date = March 2013 | pmid = 22902743 | pmc = 4077381 | doi = 10.1177/1933719112453507 }}
*{{cite journal |vauthors=Romano G, Acunzo M, Garofalo M, Di Leva G, Cascione L, Zanca C, Bolon B, Condorelli G, Croce CM |title=MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=109 |issue=41 |pages=16570–5 |year=2012 |pmid=23012423 |pmc=3478630 |doi=10.1073/pnas.1207917109 |url=}}
* {{cite journal | vauthors = Romano G, Acunzo M, Garofalo M, Di Leva G, Cascione L, Zanca C, Bolon B, Condorelli G, Croce CM | title = MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 41 | pages = 16570–5 | date = October 2012 | pmid = 23012423 | pmc = 3478630 | doi = 10.1073/pnas.1207917109 }}


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Revision as of 03:00, 22 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MicroRNA 494 is a microRNA that in humans is encoded by the MIR494 gene.[1]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. This RefSeq represents the predicted microRNA stem-loop.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: MicroRNA 494". Retrieved 2017-10-19.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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