MDM4

Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)
File:PBB Protein MDM4 image.jpg PDB rendering based on 2cr8.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2cr8​
Identifiers
Symbols	MDM4 ; DKFZp781B1423; MDMX; MGC132766; MRP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1794
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MDM4 205655 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse), also known as MDM4, is a human gene.

The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2

Further reading

• Meulmeester E, Pereg Y, Shiloh Y, Jochemsen AG (2006). "ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation". Cell Cycle. 4 (9): 1166–70. PMID 16082221.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Shvarts A, Steegenga WT, Riteco N; et al. (1996). "MDMX: a novel p53-binding protein with some functional properties of MDM2". EMBO J. 15 (19): 5349–57. PMID 8895579.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shvarts A, Bazuine M, Dekker P; et al. (1997). "Isolation and identification of the human homolog of a new p53-binding protein, Mdmx". Genomics. 43 (1): 34–42. doi:10.1006/geno.1997.4775. PMID 9226370.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanimura S, Ohtsuka S, Mitsui K; et al. (1999). "MDM2 interacts with MDMX through their RING finger domains". FEBS Lett. 447 (1): 5–9. PMID 10218570.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ongkeko WM, Wang XQ, Siu WY; et al. (1999). "MDM2 and MDMX bind and stabilize the p53-related protein p73". Curr. Biol. 9 (15): 829–32. PMID 10469568.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sharp DA, Kratowicz SA, Sank MJ, George DL (2000). "Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein". J. Biol. Chem. 274 (53): 38189–96. PMID 10608892.CS1 maint: Multiple names: authors list (link)
• Jackson MW, Lindstrom MS, Berberich SJ (2001). "MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation". J. Biol. Chem. 276 (27): 25336–41. doi:10.1074/jbc.M010685200. PMID 11297540.CS1 maint: Multiple names: authors list (link)
• Parant J, Chavez-Reyes A, Little NA; et al. (2001). "Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53". Nat. Genet. 29 (1): 92–5. doi:10.1038/ng714. PMID 11528400.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gentiletti F, Mancini F, D'Angelo M; et al. (2002). "MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts". Oncogene. 21 (6): 867–77. doi:10.1038/sj.onc.1205137. PMID 11840332.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harris RA, Yang A, Stein RC; et al. (2002). "Cluster analysis of an extensive human breast cancer cell line protein expression map database". Proteomics. 2 (2): 212–23. PMID 11840567.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gu J, Kawai H, Nie L; et al. (2002). "Mutual dependence of MDM2 and MDMX in their functional inactivation of p53". J. Biol. Chem. 277 (22): 19251–4. doi:10.1074/jbc.C200150200. PMID 11953423.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Migliorini D, Lazzerini Denchi E, Danovi D; et al. (2002). "Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development". Mol. Cell. Biol. 22 (15): 5527–38. PMID 12101245.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wistow G, Bernstein SL, Wyatt MK; et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sabbatini P, McCormick F (2002). "MDMX inhibits the p300/CBP-mediated acetylation of p53". DNA Cell Biol. 21 (7): 519–25. doi:10.1089/104454902320219077. PMID 12162806.
• Li C, Chen L, Chen J (2002). "DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms". Mol. Cell. Biol. 22 (21): 7562–71. PMID 12370303.CS1 maint: Multiple names: authors list (link)
• Badciong JC, Haas AL (2003). "MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination". J. Biol. Chem. 277 (51): 49668–75. doi:10.1074/jbc.M208593200. PMID 12393902.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kadakia M, Brown TL, McGorry MM, Berberich SJ (2003). "MdmX inhibits Smad transactivation". Oncogene. 21 (57): 8776–85. doi:10.1038/sj.onc.1205993. PMID 12483531.CS1 maint: Multiple names: authors list (link)