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Mitogen-activated protein kinase kinase 7
Symbol(s) MAP2K7; Jnkk2; MAPKK7; MKK7; PRKMK7
External IDs OMIM: 603014 MGI1346871 Homologene56548
Human Mouse
Entrez 5609 26400
Ensembl na ENSMUSG00000002948
Uniprot na Q8CE90
Refseq NM_145185 (mRNA)
NP_660186 (protein)
NM_001042557 (mRNA)
NP_001036022 (protein)
Location na Chr 8: 4.24 - 4.25 Mb
Pubmed search [1] [2]

Mitogen-activated protein kinase kinase 7, also known as MAP2K7, is a human gene.[1]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.[1]


Further reading

  • Tournier C, Whitmarsh AJ, Cavanagh J; et al. (1997). "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7337–42. PMID 9207092. 
  • Lu X, Nemoto S, Lin A (1997). "Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38.". J. Biol. Chem. 272 (40): 24751–4. PMID 9312068. 
  • Wu Z, Wu J, Jacinto E, Karin M (1997). "Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase.". Mol. Cell. Biol. 17 (12): 7407–16. PMID 9372971. 
  • Wang Y, Su B, Sah VP; et al. (1998). "Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.". J. Biol. Chem. 273 (10): 5423–6. PMID 9488659. 
  • Foltz IN, Gerl RE, Wieler JS; et al. (1998). "Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli.". J. Biol. Chem. 273 (15): 9344–51. PMID 9535930. 
  • Yang J, New L, Jiang Y; et al. (1998). "Molecular cloning and characterization of a human protein kinase that specifically activates c-Jun N-terminal kinase.". Gene. 212 (1): 95–102. PMID 9661668. 
  • Merritt SE, Mata M, Nihalani D; et al. (1999). "The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate.". J. Biol. Chem. 274 (15): 10195–202. PMID 10187804. 
  • Deacon K, Blank JL (1999). "MEK kinase 3 directly activates MKK6 and MKK7, specific activators of the p38 and c-Jun NH2-terminal kinases.". J. Biol. Chem. 274 (23): 16604–10. PMID 10347227. 
  • Yasuda J, Whitmarsh AJ, Cavanagh J; et al. (2000). "The JIP group of mitogen-activated protein kinase scaffold proteins.". Mol. Cell. Biol. 19 (10): 7245–54. PMID 10490659. 
  • Kelkar N, Gupta S, Dickens M, Davis RJ (2000). "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.". Mol. Cell. Biol. 20 (3): 1030–43. PMID 10629060. 
  • Cheng J, Yang J, Xia Y; et al. (2000). "Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.". Mol. Cell. Biol. 20 (7): 2334–42. PMID 10713157. 
  • Negri S, Oberson A, Steinmann M; et al. (2000). "cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein.". Genomics. 64 (3): 324–30. PMID 10756100. doi:10.1006/geno.2000.6129. 
  • Karandikar M, Xu S, Cobb MH (2001). "MEKK1 binds raf-1 and the ERK2 cascade components.". J. Biol. Chem. 275 (51): 40120–7. PMID 10969079. doi:10.1074/jbc.M005926200. 
  • Fleming Y, Armstrong CG, Morrice N; et al. (2001). "Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.". Biochem. J. 352 Pt 1: 145–54. PMID 11062067. 
  • Vitale G, Bernardi L, Napolitani G; et al. (2001). "Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor.". Biochem. J. 352 Pt 3: 739–45. PMID 11104681. 
  • Chayama K, Papst PJ, Garrington TP; et al. (2001). "Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells.". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4599–604. PMID 11274363. doi:10.1073/pnas.081021898. 
  • Acierno JS, Kennedy JC, Falardeau JL; et al. (2001). "A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2.". Genomics. 73 (2): 203–10. PMID 11318610. doi:10.1006/geno.2001.6526. 
  • Tournier C, Dong C, Turner TK; et al. (2001). "MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines.". Genes Dev. 15 (11): 1419–26. PMID 11390361. doi:10.1101/gad.888501. 
  • Gross EA, Callow MG, Waldbaum L; et al. (2002). "MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest.". J. Biol. Chem. 277 (16): 13873–82. PMID 11836244. doi:10.1074/jbc.M111994200. 
  • Kawaguchi M, Onuchic LF, Huang SK (2002). "Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-1.". J. Biol. Chem. 277 (18): 15229–32. PMID 11891214. doi:10.1074/jbc.C100641200.