MAP2K1IP1

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Mitogen-activated protein kinase kinase 1 interacting protein 1
File:PBB Protein MAP2K1IP1 image.jpg
PDB rendering based on 1sko.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols MAP2K1IP1 ; MP1
External IDs Template:OMIM5 HomoloGene: 10539
RNA expression pattern
File:PBB GE MAP2K1IP1 217971 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Mitogen-activated protein kinase kinase 1 interacting protein 1, also known as MAP2K1IP1, is a human gene.[1]. It was initially called MP1 (MEK1 binding Partner 1) when it was isolated in a yeast two hybrid screen using MEK1 as a bait [2]. Subsequently Huber and colleagues found that a late endosomal/lysosome enriched protein of 14 kDa (p14) interacted with MP1[3] and this interaction is required for localizing this dimer to late endosome [4]. Binding of MP1 to p14 is of high affinity (~12nM)[5]. The crystal structure of MP1/p14 dimer has been solved by two independent groups [6] [7]. MP1/p14 complex appears necessary for EGF mediated activation of ERK [8][9].Further, MP1 is required for efficient cell spreading on fibronectin. During acute cell spreading MP1 appears to downregulate Rho GTPase activity necessary for remodeling focal adhesions and membrane production at the leading edge[10].

The protein encoded by this gene was identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1. This protein enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1".
  2. ↑ MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ. Science. 1998 Sep 11;281(5383):1668-71.
  3. ↑ Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG, Lottspeich F, Huber LA. 2001.A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. J Cell Biol. 2001 Feb 19;152(4):765-76.
  4. ↑ Teis D, Wunderlich W, Huber LA.2002. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev Cell. 2002 Dec;3(6):803-14.
  5. ↑ Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T.2004. Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10984-9.
  6. ↑ Lunin VV, Munger C, Wagner J, Ye Z, Cygler M, Sacher M. The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling. 2004 . J Biol Chem. May 28;279(22):23422-30. Epub 2004 Mar 11.
  7. ↑ Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T..2004. Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10984-9
  8. ↑ Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD.2005.The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. Mol Cell Biol. 2005 Jun;25(12):5119-33
  9. ↑ Teis D, Wunderlich W, Huber LA.2002. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev Cell. 2002 Dec;3(6):803-14.
  10. ↑ Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD.2005.The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. Mol Cell Biol. 2005 Jun;25(12):5119-33

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
  • Schaeffer HJ, Catling AD, Eblen ST; et al. (1998). "MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade". Science. 281 (5383): 1668–71. PMID 9733512.
  • Okabe S, Tauchi T, Morita H; et al. (1999). "Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway". Exp. Hematol. 27 (10): 1542–7. PMID 10517496.
  • Wunderlich W, Fialka I, Teis D; et al. (2001). "A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment". J. Cell Biol. 152 (4): 765–76. PMID 11266467.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Teis D, Wunderlich W, Huber LA (2003). "Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction". Dev. Cell. 3 (6): 803–14. PMID 12479806.
  • Channavajhala PL, Wu L, Cuozzo JW; et al. (2004). "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling". J. Biol. Chem. 278 (47): 47089–97. doi:10.1074/jbc.M306002200. PMID 12975377.
  • Paces-Fessy M, Boucher D, Petit E; et al. (2004). "The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins". Biochem. J. 378 (Pt 2): 353–62. doi:10.1042/BJ20030786. PMID 14611647.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lunin VV, Munger C, Wagner J; et al. (2004). "The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling". J. Biol. Chem. 279 (22): 23422–30. doi:10.1074/jbc.M401648200. PMID 15016825.
  • Vomastek T, Schaeffer HJ, Tarcsafalvi A; et al. (2004). "Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists". Proc. Natl. Acad. Sci. U.S.A. 101 (18): 6981–6. doi:10.1073/pnas.0305894101. PMID 15118098.
  • Kurzbauer R, Teis D, de Araujo ME; et al. (2004). "Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes". Proc. Natl. Acad. Sci. U.S.A. 101 (30): 10984–9. doi:10.1073/pnas.0403435101. PMID 15263099.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Sharma C, Vomastek T, Tarcsafalvi A; et al. (2005). "MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling". J. Cell. Biochem. 94 (4): 708–19. doi:10.1002/jcb.20344. PMID 15547943.
  • Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD (2005). "The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals". Mol. Cell. Biol. 25 (12): 5119–33. doi:10.1128/MCB.25.12.5119-5133.2005. PMID 15923628.
  • Villegas SN, Njaine B, Linden R, Carri NG (2007). "Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways". Brain Res. Bull. 71 (1–3): 116–26. doi:10.1016/j.brainresbull.2006.08.014. PMID 17113937.
  • Teis D, Taub N, Kurzbauer R; et al. (2007). "p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis". J. Cell Biol. 175 (6): 861–8. doi:10.1083/jcb.200607025. PMID 17178906.
  • Brahma A, Dalby KN (2007). "Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimer". Arch. Biochem. Biophys. 460 (1): 85–91. doi:10.1016/j.abb.2006.11.031. PMID 17254543.
  • Vomastek T, Iwanicki MP, Schaeffer HJ; et al. (2007). "RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility". Mol. Cell. Biol. 27 (23): 8296–305. doi:10.1128/MCB.00598-07. PMID 17908799.

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